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Activation of the TrkBR by brain\u2010derived neurotrophic factor (BDNF) or neurotrophin 4\/5 (NT\u20104\/5) promotes neuronal survival, differentiation, and synaptic function. It is shown that in the pathogenesis of several neurodegenerative conditions (Alzheimer's disease, Parkinson's disease, Huntington's disease) the BDNF\/TrkBR signaling pathway is impaired. Since it is known that GPCRs and TrkR are regulating several cell functions by interacting with each other and generating a cross\u2010communication in this review we have focused on the interaction between different GPCRs and their ligands on BDNF\/TrkBR signaling pathway.<\/jats:p>","DOI":"10.1002\/med.22075","type":"journal-article","created":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T10:36:39Z","timestamp":1724495799000},"page":"274-310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Indirect influence on the BDNF\/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4722-0903","authenticated-orcid":false,"given":"Mirjana","family":"Antonijevic","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Caen Normandie, Normandie Univ., CERMN Caen 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