{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:43Z","timestamp":1786978243422,"version":"build-2736575974"},"reference-count":187,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medicinal Research Reviews"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The monkeypox (mpox) outbreak has once again become a Public Health Emergency of International Concern, increasing the focus of research on the development of anti\u2010monkeypox drugs. Monkeypox virus (MPXV) is a member of the\n                    <jats:italic>Orthopxviridae<\/jats:italic>\n                    genus, which also contains the variola virus, cowpox virus, and vaccinia virus. As no specific drugs for mpox are available, tecovirimat and brincidofovir for the treatment of smallpox infection are recommended to treat Mpox infection. The purpose of this review is to provide reference for further development of Mpox virus antiviral drugs by summarizing the resolving Mpox virus target protein structures and its mechanism of action, drugs with potential anti\u2010Mpox virus activity, in vitro and in vivo inhibitory activity detection methods of anti\u2010Mpox virus drugs, and the prevention of drug resistance. We hope to facilitate the discovery of antiviral drugs for MPXV by providing insights into the further development of appropriate anti\u2010Mpox drugs based on currently available viral protein targets.\n                  <\/jats:p>","DOI":"10.1002\/med.70004","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T07:50:31Z","timestamp":1753689031000},"page":"40-69","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Recent Progress in the Discovery of Anti\u2010Mpox Agents"],"prefix":"10.1002","volume":"46","author":[{"given":"Le","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7302-2214","authenticated-orcid":false,"given":"Xinyong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences Shandong University Jinan China"},{"name":"China\u2010Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9232-953X","authenticated-orcid":false,"given":"Dongwei","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences Shandong University Jinan China"},{"name":"China\u2010Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,28]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)02075-X"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3001769"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2604.191164"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01437-4"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01907-y"},{"key":"e_1_2_13_7_1","unstructured":"World Health Organization WHO Director\u2010General Declares Mpox Outbreak a Public Health Emergency of International Concern. (2024) https:\/\/www.who.int\/news\/item\/14-08-2024-who-director-general-declares-mpox-outbreak-a-public-health-emergency-of-international-concern."},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/17.3.643"},{"key":"e_1_2_13_9_1","volume-title":"Vaccines and Immunization for Monkeypox: Interim Guidance","author":"World Health Organization","year":"2022"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41628-5"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01432-5"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1203410"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.01.017"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04295"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28306"},{"key":"e_1_2_13_16_1","volume-title":"Clinical Management and Infection Prevention and Control for Monkeypox: Interim Rapid Response Guidance","author":"World Health Organization","year":"2022"},{"key":"e_1_2_13_17_1","unstructured":"European Medicines Agency Tecovirimat SIGA (2024) https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/tecovirimat-siga."},{"key":"e_1_2_13_18_1","unstructured":"Centers for Disease Control and Prevention Tecovirimat (TPOXX) for Treatment of Mpox (2024) https:\/\/www.cdc.gov\/mpox\/hcp\/clinical-care\/tecovirimat.html."},{"key":"e_1_2_13_19_1","unstructured":"National Institutes of Health The Antiviral Tecovirimat is Safe but did not Improve Clade I Mpox Resolution in Democratic Republic of the Congo. (2024) https:\/\/www.nih.gov\/news-events\/news-releases\/antiviral-tecovirimat-safe-did-not-improve-clade-i-mpox-resolution-democratic-republic-congo."},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-024-00741-5"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006634"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c00069"},{"issue":"2","key":"e_1_2_13_23_1","first-page":"186","article-title":"Antivirals for the Treatment of Monkeypox: Utilization in the General and HIV\u2010Positive Population and Gaps for Research. A Short Narrative Review","volume":"31","author":"Dt I.","year":"2023","journal-title":"Le infezioni in Medicina"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14091874"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-83-12-2915"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-virology-091919-104752"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)36019-8"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M511239200"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00044-16"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00445-15"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.4.2917-2926.1998"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2023.10.038"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01542-z"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2021.167009"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3058"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adg2331"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2024.03.004"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.132231"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60703-4"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.8.3153-3162.2005"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2009.01.005"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac622"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.5.1329-1335.2002"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01257-08"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01601-13"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2007.06.005"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.4.1336-1341.2006"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(02)00841-7"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.1.84-87.2001"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(01)00217-0"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.11.023"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(76)90128-8"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2024.2369193"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-38019-1"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2022.04.010"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1515"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2023.105663"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17495-9"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44259-024-00040-9"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00151A"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2023.105714"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.5b00070"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2002.1446"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.127565"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601912"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-023-01142-0"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-024-00680-1"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2015.02.003"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02405-16"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1805855115"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virs.2023.12.006"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2006.08.005"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00775-4"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2005.04.006"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.24.021605.090529"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2006.09.006"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2008.05.016"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10142-023-01168-z"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pep.2024.106480"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2007.0113"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.69.12.7823-7834.1995"},{"issue":"6","key":"e_1_2_13_82_1","first-page":"469","article-title":"Crystal Structure of Monkeypox H1 Phosphatase, an Antiviral Drug Target","volume":"14","author":"Cui W.","year":"2023","journal-title":"Protein and Cell"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009372"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-0928-6"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.113831"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-023-05824-4"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202016805"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2024.01.008"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40748-2"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri727"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1909414116"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-6-44"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2020.1819791"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11041106"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28306"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-022-01269-8"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27113577"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.000422"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbed.12323"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.000216"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-020-05034-x"},{"key":"e_1_2_13_102_1","unstructured":"World Health Organization 2021 WHO Advisory Committee on Variola Virus Research: Report of the Twenty\u2010third Meeting Virtual Meeting. 3\u20104 November https:\/\/www.who.int\/publications\/i\/item\/9789240046740."},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.129.4.795"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.03586-23"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm040068f"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.05416-11"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00841-22"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557520666200818212408"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2022.09.002"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-2-63"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.20.11279-11283.2003"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24087119"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.22.12147-12156.2004"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27165277"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11072025"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1810398115"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/2241280a0"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2006.09.031"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1033.2002.03309.x"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00770-07"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11030-023-10797-2"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1159389"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkad099"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.08.055"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-57165-7_8"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2021.05.009"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00304-15"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3581"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3787"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3212"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.3136"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1725066"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26232"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.000921"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.12.7845-7851.2005"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-1676"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17834"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.icb.7100033"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13568-023-01517-y"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.390161"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3210557"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007608"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568005053174627"},{"key":"e_1_2_13_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2018.02.007"},{"key":"e_1_2_13_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2019.01.011"},{"key":"e_1_2_13_146_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1265"},{"key":"e_1_2_13_147_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01814-10"},{"key":"e_1_2_13_148_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200523220"},{"key":"e_1_2_13_149_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M400343200"},{"key":"e_1_2_13_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00443-w"},{"key":"e_1_2_13_151_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12337"},{"key":"e_1_2_13_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(91)90058-J"},{"key":"e_1_2_13_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2021.105086"},{"key":"e_1_2_13_154_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.20.13139-13149.2005"},{"key":"e_1_2_13_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-024-00739-z"},{"key":"e_1_2_13_156_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00621-10"},{"issue":"3","key":"e_1_2_13_157_1","article-title":"Therapeutics for Treating Mpox in Humans","volume":"3","author":"Fox T.","year":"2023","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_13_158_1","doi-asserted-by":"publisher","DOI":"10.7326\/L23-0131"},{"key":"e_1_2_13_159_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00568-23"},{"key":"e_1_2_13_160_1","unstructured":"Centers for Disease Control and Prevention Update on Managing Monkeypox in Patients Receiving Therapeutics. (2024) https:\/\/emergency.cdc.gov\/han\/2022\/han00481.asp."},{"key":"e_1_2_13_161_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28791"},{"key":"e_1_2_13_162_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2214921"},{"key":"e_1_2_13_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00273-8"},{"key":"e_1_2_13_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2023.09.014"},{"key":"e_1_2_13_165_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2912.230849"},{"key":"e_1_2_13_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00044-0"},{"key":"e_1_2_13_167_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad052"},{"key":"e_1_2_13_168_1","unstructured":"World Health Organization Antimicrobial resistance (2024) https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/antimicrobial-resistance."},{"key":"e_1_2_13_169_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00648"},{"key":"e_1_2_13_170_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.51.1.151"},{"key":"e_1_2_13_171_1","doi-asserted-by":"publisher","DOI":"10.1093\/femspd\/ftz021"},{"key":"e_1_2_13_172_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.2022"},{"key":"e_1_2_13_173_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS01084G"},{"key":"e_1_2_13_174_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b07366"},{"key":"e_1_2_13_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2016.03.010"},{"key":"e_1_2_13_176_1","doi-asserted-by":"publisher","DOI":"10.1021\/cb400468c"},{"key":"e_1_2_13_177_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201102762"},{"key":"e_1_2_13_178_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1711463114"},{"key":"e_1_2_13_179_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm9000133"},{"key":"e_1_2_13_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2018.07.014"},{"key":"e_1_2_13_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01673-2"},{"key":"e_1_2_13_182_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm400856t"},{"key":"e_1_2_13_183_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40169-017-0181-2"},{"key":"e_1_2_13_184_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2912.231146"},{"key":"e_1_2_13_185_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00972-23"},{"key":"e_1_2_13_186_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7209a4"},{"key":"e_1_2_13_187_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00762-07"},{"key":"e_1_2_13_188_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm301735k"}],"container-title":["Medicinal Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.70004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T10:10:51Z","timestamp":1764756651000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/med.70004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,28]]},"references-count":187,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/med.70004"],"URL":"https:\/\/doi.org\/10.1002\/med.70004","archive":["Portico"],"relation":{},"ISSN":["0198-6325","1098-1128"],"issn-type":[{"value":"0198-6325","type":"print"},{"value":"1098-1128","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,28]]},"assertion":[{"value":"2024-11-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}