{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T23:29:12Z","timestamp":1783812552244,"version":"3.55.0"},"reference-count":118,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medicinal Research Reviews"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Alzheimer's disease (AD) and Parkinson's disease (PD), which are characterized by the accumulation of misfolded protein aggregates and cognitive\/motor dysfunction, are the most prevalent neurodegenerative diseases (NDDs). Despite strategic investigations aimed at augmenting the pharmaceutical pipeline, available drugs for AD and PD merely slow disease progression without curing or treating the underlying pathology. Recent technological advances have given rise to digital therapeutics (DTx): software systems that aim to prevent, cure, and manage specific diseases, including NDDs. For AD and PD, the majority of DTx focus on enhancing cognitive\/executive function and motor\u2010related functions, respectively. In this review, we describe the status of therapeutic development for AD and PD, as well as the characteristics and status of DTx targeting these NDDs. In addition, we address the limitations and challenges of DTx and their implications for the treatment of AD and PD. Ultimately, this review provides insights into the potential of DTx as a therapeutic modality and future directions for the development of DTx targeting AD and PD.<\/jats:p>","DOI":"10.1002\/med.70005","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T05:58:38Z","timestamp":1754027918000},"page":"316-327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Digital Therapeutics for Alzheimer's and Parkinson's Diseases: Current Trends and Future Perspectives"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6598-3865","authenticated-orcid":false,"given":"Yoo Joo","family":"Jeong","sequence":"first","affiliation":[{"name":"Department of Neural Development and Disease Korea Brain Research Institute (KBRI) Daegu Republic of Korea"},{"name":"AI\u2010based Neurodevelopmental Diseases Digital Therapeutics Group Korea Brain Research Institute (KBRI) Daegu Republic of Korea"},{"name":"Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science &amp; Technology Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4532-6448","authenticated-orcid":false,"given":"Hyun\u2010ju","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neural Development and Disease Korea Brain Research Institute (KBRI) Daegu Republic of Korea"},{"name":"AI\u2010based Neurodevelopmental Diseases Digital Therapeutics Group Korea Brain Research Institute (KBRI) Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1191-6079","authenticated-orcid":false,"given":"Jun\u2010Su","family":"Kim","sequence":"additional","affiliation":[{"name":"AI\u2010based Neurodevelopmental Diseases Digital Therapeutics Group Korea Brain Research Institute (KBRI) Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9955-4254","authenticated-orcid":false,"given":"Seung\u2010Jae","family":"Kim","sequence":"additional","affiliation":[{"name":"AI\u2010based Neurodevelopmental Diseases Digital Therapeutics Group Korea Brain Research Institute (KBRI) Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7309-4675","authenticated-orcid":false,"given":"Unhui","family":"Jo","sequence":"additional","affiliation":[{"name":"AI\u2010based Neurodevelopmental Diseases Digital Therapeutics Group Korea Brain Research Institute (KBRI) Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3448-3783","authenticated-orcid":false,"given":"Jin Yeop","family":"Park","sequence":"additional","affiliation":[{"name":"AI\u2010based Neurodevelopmental Diseases Digital Therapeutics Group Korea Brain Research Institute (KBRI) Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3617-0348","authenticated-orcid":false,"given":"Su Jin","family":"Jun","sequence":"additional","affiliation":[{"name":"AI\u2010based Neurodevelopmental Diseases Digital Therapeutics Group Korea Brain Research Institute (KBRI) Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1606-6958","authenticated-orcid":false,"given":"Won Seok","family":"Lee","sequence":"additional","affiliation":[{"name":"AI\u2010based Neurodevelopmental Diseases Digital Therapeutics Group Korea Brain Research Institute (KBRI) Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingoo","family":"Song","sequence":"additional","affiliation":[{"name":"StoneLab Inc. Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1044-9249","authenticated-orcid":false,"given":"Donggii","family":"Kim","sequence":"additional","affiliation":[{"name":"Digital Health Division Daegu Digital Innovation Promotion Agency Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2451-5426","authenticated-orcid":false,"given":"Gyoujin","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Institute of Quantum Biology Sungkyunkwan University Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5443-1066","authenticated-orcid":false,"given":"Jeong\u2010Heon","family":"Song","sequence":"additional","affiliation":[{"name":"AI\u2010based Neurodevelopmental Diseases Digital Therapeutics Group Korea Brain Research Institute (KBRI) Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8877-8594","authenticated-orcid":false,"given":"Hyang\u2010Sook","family":"Hoe","sequence":"additional","affiliation":[{"name":"Department of Neural Development and Disease Korea Brain Research Institute (KBRI) Daegu Republic of Korea"},{"name":"AI\u2010based Neurodevelopmental Diseases Digital Therapeutics Group Korea Brain Research Institute (KBRI) Daegu Republic of Korea"},{"name":"Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science &amp; Technology Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.12.032"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2018.02061"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-clinpsy-032813-153653"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02443-z"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00356"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.573696"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-004-0956-9"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-239901"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12385"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/picr.PICR_89_19"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-023-00777-z"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205020666230206124155"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2021.106319"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.2196\/55569"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12911-018-0714-7"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19010364"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2020.101790"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-020-00939-x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.880897"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-024-00803-1"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12020289"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2023.09.2294"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2022.28"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1269359"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41514-022-00093-y"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/172192"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19095531"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rehab.2021.101492"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2023.29.6.685"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2023.2185672"},{"key":"e_1_2_11_32_1","doi-asserted-by":"crossref","unstructured":"J. V.Filoteo E. M.Cox M.Split M.Gross M.Culjat andD.Keene \u201cEvaluation of ReminX as a Behavioral Intervention for Mild to Moderate Dementia \u201d paper presented at 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) 2018.","DOI":"10.1109\/EMBC.2018.8513049"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0144686X21001446"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2011.10.016"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2019.06.026"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18105290"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00240"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-016-1132-y"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2022.843051"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyg.12141"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132168"},{"issue":"1","key":"e_1_2_11_42_1","first-page":"53","article-title":"Dementia Caregiver Burden: A Review of the Literature and Guidelines for Assessment and Intervention","volume":"51","author":"Dunkin J. J.","year":"1998","journal-title":"Neurology"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intcom.2010.03.003"},{"key":"e_1_2_11_44_1","volume-title":"Technology and Aging","author":"Astell A.","year":"2008"},{"key":"e_1_2_11_45_1","first-page":"80","article-title":"A Succinct Overview of Virtual Reality Technology Use in Alzheimer's Disease","volume":"7","author":"Garc\u00eda\u2010Betances R. I.","year":"2015","journal-title":"Frontiers in Aging Neuroscience"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.1062162"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000346"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2019.09.016"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2012.12.031"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00033"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-202407"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-219002"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2021.08.002"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968320961114"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-016-0003-z"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7962826"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968314562111"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.930010209"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-019-04167-w"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-212802"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/283890"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1980-5764-2016dn1004015"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyg.12294"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2007000300008"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1159\/000336598"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10994-015-5529-5"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.10.058"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2022.10.021"},{"key":"e_1_2_11_69_1","volume-title":"Handbook of Neurologic Music Therapy","author":"Thaut M.","year":"2014"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.00243"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.818559"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2019.07.013"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16232-5"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(01)00015-3"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2013-000741"},{"key":"e_1_2_11_76_1","unstructured":"Health NIf Excellence C. Parkinson's Disease in Over 20s: Diagnosis and Management. NICE London. 2006."},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02793.x"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1368-5031.2005.00426.x"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25670"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/pzab053"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2020.102085"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2020.05.021"},{"issue":"12","key":"e_1_2_11_83_1","article-title":"Virtual Reality for Rehabilitation in Parkinson's Disease","volume":"12","author":"Dockx K.","year":"2016","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0224819"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2022.107579"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10536"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.3389\/fdsfr.2022.900946"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13101523"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.3389\/fdgth.2023.1064115"},{"key":"e_1_2_11_90_1","unstructured":"ObvioHealth. Sensors Wearables and Digital Biomarkers: The Current and Future State of Digital Instruments in Clinical Research accessed January 21 2025 https:\/\/www.obviohealth.com\/resources\/sensors-wearables-and-digital-biomarkers-the-current-and-future-state-of-digital-instruments-in-clinical-research."},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.2196\/12785"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-019-0084-2"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-023-00602-0"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1089\/g4h.2018.0029"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2025.1560315"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-023-02374-2"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2025.1522552"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874440000802010052"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2007.05.070"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2006.09.007"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(00)00153-6"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(00)00454-5"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-230485"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.4236\/aad.2024.133005"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2020.108618"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.03.067"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00366"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2005.12.012"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2023.03.363"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11571-016-9415-z"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.832637"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2018.04.752"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40814-016-0099-2"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcae259"},{"key":"e_1_2_11_115_1","unstructured":"R.Kaplan N. M.C. M.Aul et al. Naturalistic Walking in Parkinson's Disease: Prefrontal Cortex Activity Measured With Functional Near\u2010Infrared Spectroscopy (fNIRS). International Congress of Parkinson's Disease and Movement Disorders. 2024."},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3181919a48"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00004"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12683"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-019-00433-1"}],"container-title":["Medicinal Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.70005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T10:10:55Z","timestamp":1764756655000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/med.70005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,31]]},"references-count":118,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/med.70005"],"URL":"https:\/\/doi.org\/10.1002\/med.70005","archive":["Portico"],"relation":{},"ISSN":["0198-6325","1098-1128"],"issn-type":[{"value":"0198-6325","type":"print"},{"value":"1098-1128","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,31]]},"assertion":[{"value":"2025-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}