{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:06:47Z","timestamp":1791083207277,"version":"4.1.0"},"reference-count":169,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:00:00Z","timestamp":1759536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:00:00Z","timestamp":1759536000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medicinal Research Reviews"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Antimicrobial peptides (AMPs), essential components of the body's innate defense system, are expected to exert and enhance their potential antimicrobials, immunomodation and other bio\u2010activities that combine with traditional antimicrobial agents and vaccines efficiently against multi\u2010drug\u2010resistant (MDR) bacteria. They are multi\u2010source (animal, plant, microbial, etc.) and multi\u2010functional (antimicrobial, immunomodulatory, anticancer, antiviral, antioxidant, etc.), and have been clearly categorized according to source, function, and structure in several AMP databases. However, there is insufficient evidence to support recognizing, developing, and utilizing the source\u2013function relationship of AMPs, as their first function is usually unknown or unclear; in addition, they are usually accompanied by some shortcomings such as weak stability, high toxicity, and production cost. These have seriously hindered their development for clinical application. Therefore, it is necessary to clarify the relationship between the AMP source and function, and establish a complete system to distinguish the first function, so that more AMP candidates can enter the pipeline of new drugs as early as possible. At the same time, the key fundamental elements, scaffold and bottom logistics were proposed for the R &amp; D pipeline of AMPs as new antimicrobial agents, including the following key points: high yielding, stability, and safety of AMPs using heterologous expression, modification, encapsulation, and coadministration toward their final successful application.<\/jats:p>","DOI":"10.1002\/med.70016","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T10:30:06Z","timestamp":1759573806000},"page":"333-351","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Unveiling the Function of Antimicrobial Peptides in Relation to Source and Structure"],"prefix":"10.1002","volume":"46","author":[{"given":"Kun","family":"Zhang","sequence":"first","affiliation":[{"name":"Gene Engineering Laboratory, Feed Research Institute Chinese Academy of Agricultural Sciences Beijing P. R. China"},{"name":"Innovative Team of Antimicrobial Peptides and Alternatives to Antibiotics, Feed Research Institute Chinese Academy of Agricultural Sciences Beijing P. R. China"},{"name":"Key Laboratory of Feed Biotechnology Department of Agriculture and Rural Affairs Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Teng","sequence":"additional","affiliation":[{"name":"Gene Engineering Laboratory, Feed Research Institute Chinese Academy of Agricultural Sciences Beijing P. R. China"},{"name":"Innovative Team of Antimicrobial Peptides and Alternatives to Antibiotics, Feed Research Institute Chinese Academy of Agricultural Sciences Beijing P. R. China"},{"name":"Key Laboratory of Feed Biotechnology Department of Agriculture and Rural Affairs Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoyu","family":"Mao","sequence":"additional","affiliation":[{"name":"Gene Engineering Laboratory, Feed Research Institute Chinese Academy of Agricultural Sciences Beijing P. R. China"},{"name":"Innovative Team of Antimicrobial Peptides and Alternatives to Antibiotics, Feed Research Institute Chinese Academy of Agricultural Sciences Beijing P. R. China"},{"name":"Key Laboratory of Feed Biotechnology Department of Agriculture and Rural Affairs Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Yang","sequence":"additional","affiliation":[{"name":"Gene Engineering Laboratory, Feed Research Institute Chinese Academy of Agricultural Sciences Beijing P. R. China"},{"name":"Innovative Team of Antimicrobial Peptides and Alternatives to Antibiotics, Feed Research Institute Chinese Academy of Agricultural Sciences Beijing P. R. China"},{"name":"Key Laboratory of Feed Biotechnology Department of Agriculture and Rural Affairs Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Hao","sequence":"additional","affiliation":[{"name":"Gene Engineering Laboratory, Feed Research Institute Chinese Academy of Agricultural Sciences Beijing P. R. China"},{"name":"Innovative Team of Antimicrobial Peptides and Alternatives to Antibiotics, Feed Research Institute Chinese Academy of Agricultural Sciences Beijing P. R. China"},{"name":"Key Laboratory of Feed Biotechnology Department of Agriculture and Rural Affairs Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4048-6055","authenticated-orcid":false,"given":"Jianhua","family":"Wang","sequence":"additional","affiliation":[{"name":"Gene Engineering Laboratory, Feed Research Institute Chinese Academy of Agricultural Sciences Beijing P. R. China"},{"name":"Innovative Team of Antimicrobial Peptides and Alternatives to Antibiotics, Feed Research Institute Chinese Academy of Agricultural Sciences Beijing P. R. China"},{"name":"Key Laboratory of Feed Biotechnology Department of Agriculture and Rural Affairs Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2022.02.005"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fux053"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-021-00649-x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.59566\/IJBS.2010.6077"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abo7793"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21542"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2108244118"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau5480"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1094\/mpmi-8-0006"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom8010004"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001067"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1821410116"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.114066"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-3588-4_1"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2017.04.002"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0952-7915(98)80029-0"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-017-0386-z"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.1010148"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.865774"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1304825"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18711-2"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.46.030184.002531"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a025288"},{"key":"e_1_2_12_25_1","volume-title":"Combination Therapy Against Multidrug Resistance","author":"Wani M. Y.","year":"2020"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.R120.002309"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.668632"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2019.02.092"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.113863"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222011172"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-020-10701-0"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cimid.2016.10.004"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003217"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0924-8579(03)00180-8"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612033454829"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M600334-MCP200"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1180"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8349712"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants13152059"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf800302f"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2018.07.002"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00299-020-02557-5"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.7.5.573"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plantsci.2019.110317"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04051"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1185723"},{"issue":"32","key":"e_1_2_12_47_1","first-page":"1","article-title":"Plectasin's Odyssey From Hopeful Beginnings to Untimely End","volume":"21","author":"Martinenghi L. D.","year":"2024","journal-title":"Michael"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00466-1"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-24199-9_10"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2017.02.006"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pep.2011.04.014"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-013-4881-2"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi0609422"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c07433"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2013.763765"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomedchemau.2c00062"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1128\/aem.62.5.1799-1802.1996"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.1.24-29.2000"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1278"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1051"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa991"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab651"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab1080"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1288"},{"key":"e_1_2_12_65_1","volume-title":"StatPearls","author":"Patel S.","year":"2020"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20194877"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0196-9781(00)00254-0"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm357"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.24.1.41.34802"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1530\/rep.1.00028"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00508"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0282(1999)51:2<129::AID-BIP3>3.0.CO;2-Y"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00259-06"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02094-10"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2010.06.048"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myaa015"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-022-06370-1"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2004.09.011"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1996.0293"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2008.06.007"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi0497087"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1021\/cb1001558"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1319900111"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.1.154"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-3588-4_6"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw018"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi002656a"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40104-022-00796-y"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113771"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/332411a0"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2004.01.014"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14225546"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.12.066"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1080\/1061186X.2016.1184273"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00081F"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.03.050"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.02.006"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010829"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm020861d"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.00168"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1093\/af\/vfy005"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2024.1339285"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.874153"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17050603"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2019.1642322"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1125426"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1028"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12291"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.227116"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0282(2000)55:1<4::AID-BIP30>3.0.CO;2-M"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2010.02.023"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms251910821"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01967563"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2014.05.013"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/46.4.523"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197047"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00534-18"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2020.9322"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-021-0649-z"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30327-3"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1002\/biot.201800606"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-594-1_20"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.691978"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1974.tb43255.x"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8545(21)00365-X"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2013.763765"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00006-08"},{"key":"e_1_2_12_128_1","unstructured":"H. K.Hoegenhaug P. H.Mygind T.Kruse et al. \u201cAntimicrobial Peptide Variants and Polynucleotides Encoding Same \u201d (2011)."},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.15.5449"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2017.05.010"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fm.2018.08.002"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1039\/c7np00020k"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2016.02.016"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.3c01664"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12934-017-0637-5"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2022.107968"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2020.1764347"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.6.1716-1719.2000"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0732-8893(00)00175-9"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-021-01074-6"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43141-023-00575-w"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-011-9632-5"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21849"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S160975"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.888540"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1425952"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2022.107962"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00041-16"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.618312"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21249637"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.3390\/md18120650"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1139\/bcb-2020-0253"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1139\/bcb-2024-0183"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.05.028"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0212858"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.12.035"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.1c00259"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.8b00776"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-022-11943-w"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jenvman.2019.01.042"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408363.2019.1631249"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb15110320"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00077-17"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1466252308001497"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl145"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-018-9524-1"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202107861"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-019-10313-3"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-019-09785-0"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21072654"}],"container-title":["Medicinal Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.70016","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/med.70016","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.70016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T07:11:45Z","timestamp":1770966705000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/med.70016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,4]]},"references-count":169,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/med.70016"],"URL":"https:\/\/doi.org\/10.1002\/med.70016","archive":["Portico"],"relation":{},"ISSN":["0198-6325","1098-1128"],"issn-type":[{"value":"0198-6325","type":"print"},{"value":"1098-1128","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,4]]},"assertion":[{"value":"2024-05-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}