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This approach demonstrated its effectiveness during SARS\u2010CoV\u20102 pandemic, when existing drugs were repurposed to combat the virus. Originally pivotal in developing antiviral treatments against HIV and HCV, viral protease inhibitors represent a structurally privileged class of compounds capable of targeting difficult and non\u2010classical protein sites. They have demonstrated promising biological activity against diverse alternative targets, including fungal pathogens, multidrug\u2010resistant bacteria, and cancer, making them prime candidates for repurposing. This mini\u2010review highlights the unique structural and physicochemical properties of approved HCV and HIV viral protease inhibitors that enable their repurposing for the development of new therapeutic agents.\n                  <\/jats:p>","DOI":"10.1002\/med.70040","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T05:39:16Z","timestamp":1775194756000},"page":"1042-1050","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Beyond Antiviral Therapy: Untapped Potential of HIV &amp; HCV Protease Inhibitors"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9939-7762","authenticated-orcid":false,"given":"Dmitrii A.","family":"Iuzabchuk","sequence":"first","affiliation":[{"name":"Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences Moscow 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