{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:48:32Z","timestamp":1786114112039,"version":"build-2736575974"},"reference-count":166,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["252300421127"],"award-info":[{"award-number":["252300421127"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22477114"],"award-info":[{"award-number":["22477114"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204213"],"award-info":[{"award-number":["82204213"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medicinal Research Reviews"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Histone deacetylases (HDACs) are key epigenetic regulators involved in a variety of cancers, rendering them attractive therapeutic targets. Although several HDAC inhibitors have achieved clinical success, challenges such as poor isoform selectivity, acquired resistance, and off\u2010target toxicity limit their broader application. Proteolysis\u2010targeting chimeras (PROTACs) represent an innovative therapeutic strategy that enables ubiquitin\u2013proteasome\u2013mediated degradation of HDACs. This approach enhances specificity, overcomes resistance mechanisms, including those resulting from point mutations or persistent target activity, and enables sustained suppression at low concentrations, owing to its catalytic and event\u2010driven mode of action. This review summarizes the structural classification and biological functions of HDACs and surveys recent advances in the design of HDAC\u2010directed PROTACs. Key emphasis is placed on rational warhead selection, linker optimization, and the strategic choice of E3 ligase recruiters to guide degradation efficiency and isoform specificity. Representative degraders are evaluated for their pharmacological characteristics and antitumor efficacy across diverse malignancies. Current challenges and future directions for the development of HDAC degraders as clinically viable agents are also discussed.<\/jats:p>","DOI":"10.1002\/med.70052","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:50:48Z","timestamp":1778244648000},"page":"1257-1278","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Histone Deacetylase Meets Protein Degradation: Accelerating Anticancer Drug Discovery"],"prefix":"10.1002","volume":"46","author":[{"given":"Jun\u2010Jie","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Metabolic Dysregulation &amp; Prevention and Treatment of Esophageal Cancer, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Key Laboratory of Henan Province for Small Molecule Drug Discovery and Application, School of Pharmaceutical Sciences Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Metabolic Dysregulation &amp; Prevention and Treatment of Esophageal Cancer, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Key Laboratory of Henan Province for Small Molecule Drug Discovery and Application, School of Pharmaceutical Sciences Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010Qian","family":"Ji","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Metabolic Dysregulation &amp; Prevention and Treatment of Esophageal Cancer, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Key Laboratory of Henan Province for Small Molecule Drug Discovery and Application, School of Pharmaceutical Sciences Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Yi","family":"Yin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Metabolic Dysregulation &amp; Prevention and Treatment of Esophageal Cancer, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Key Laboratory of Henan Province for Small Molecule Drug Discovery and Application, School of Pharmaceutical Sciences Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng\u2010Zhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Metabolic Dysregulation &amp; Prevention and Treatment of Esophageal Cancer, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Key Laboratory of Henan Province for Small Molecule Drug Discovery and Application, School of Pharmaceutical Sciences Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Metabolic Dysregulation &amp; Prevention and Treatment of Esophageal Cancer, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Key Laboratory of Henan Province for Small Molecule Drug Discovery and Application, School of Pharmaceutical Sciences Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Min","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Metabolic Dysregulation &amp; Prevention and Treatment of Esophageal Cancer, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Key Laboratory of Henan Province for Small Molecule Drug Discovery and Application, School of Pharmaceutical Sciences Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8151-6558","authenticated-orcid":false,"given":"Siqi","family":"Feng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Metabolic Dysregulation &amp; Prevention and Treatment of Esophageal Cancer, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Key Laboratory of Henan Province for Small Molecule Drug Discovery and Application, School of Pharmaceutical Sciences Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1410-329X","authenticated-orcid":false,"given":"Ning","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine University of Hong Kong  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2094-0820","authenticated-orcid":false,"given":"Guo\u2010Liang","family":"Lu","sequence":"additional","affiliation":[{"name":"Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences The University of Auckland Auckland New Zealand"},{"name":"Maurice Wilkins Centre The University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Maurice Wilkins Centre The University of Auckland Auckland New Zealand"},{"name":"Department of Biomedicine and Medical Diagnostics, School of Science Auckland University of Technology Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piet","family":"Herdewijn","sequence":"additional","affiliation":[{"name":"XNA Platform, School of Pharmaceutical Sciences Zhengzhou University Zhengzhou China"},{"name":"Rega Institute for Medical Research, Medicinal Chemistry KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Chao","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Metabolic Dysregulation &amp; Prevention and Treatment of Esophageal Cancer, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Key Laboratory of Henan Province for Small Molecule Drug Discovery and Application, School of Pharmaceutical Sciences Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Yan","sequence":"additional","affiliation":[{"name":"Orthopedic Ward 3, The Fifth Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7531-044X","authenticated-orcid":false,"given":"Xing\u2010Jie","family":"Dai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Metabolic Dysregulation &amp; Prevention and Treatment of Esophageal Cancer, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Key Laboratory of Henan Province for Small Molecule Drug Discovery and Application, School of Pharmaceutical Sciences Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202006725"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2023.07.010"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115746"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2024.2391289"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.120946"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1272"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201500486"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c01345"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2025.108932"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c00541"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2025.112263"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c01677"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph18040577"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.0c00462"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26175151"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-024-02052-1"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.117185"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2017.1353077"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115938"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13061"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706487104"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.92526"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2024.107887"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00371-6"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112698"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26237241"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25214991"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c00397"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CS00193D"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-020-00885-3"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2023.02.007"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210613"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114290"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC03243C"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113946"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CS00200K"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7310149"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.116129"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119504"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-022-01770-4"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210610"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-019-0053-2"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2024.102262"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228828"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes11050556"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00412-013-0441-x"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a018713"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X19666210609160017"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c02179"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c00830"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01971-05"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2024.104094"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108190"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom14020140"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1302\/2046-3758.92.BJR-2019-0172.R1"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2011.01321.x"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.RA118.001253"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae036"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1826-05.2005"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00109-2"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-018-0379-9"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00258"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12079"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1216548"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1186231"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01257-8"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2022-0031"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14091076"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4181-06.2007"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/lifemedi\/lnaf019"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom15121655"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes12091361"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00126-6"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00524-4"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2010.07.009"},{"key":"e_1_2_10_77_1","first-page":"64","article-title":"HDAC Inhibitors With Potential to Overcome Drug Resistance in Castration\u2010Resistant Prostate Cancer","volume":"5","author":"Biersack B.","year":"2022","journal-title":"Cancer Drug Resistance"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111871200"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.2174\/156802609788085304"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2015.01.007"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a026831"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30512-8"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00362"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2019.115087"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061291"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-18-1177"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01341-0"},{"issue":"19","key":"e_1_2_10_89_1","first-page":"7025","article-title":"Synergistic Activation of Functional Estrogen Receptor (ER)\u2010Alpha by DNA Methyltransferase and Histone Deacetylase Inhibition in Human ER\u2010Alpha\u2010Negative Breast Cancer Cells","volume":"61","author":"Yang X.","year":"2001","journal-title":"Cancer Research"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.116884"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2019.03.003"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c00939"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00966"},{"issue":"1","key":"e_1_2_10_94_1","first-page":"64","article-title":"HDAC Inhibitors With Potential to Overcome Drug Resistance in Castration\u2010Resistant Prostate Cancer","volume":"5","author":"Biersack B.","year":"2022","journal-title":"Cancer Drug Resistance"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604199"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c00830"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00312-3"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30958-8"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-61295-6"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.add3243"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.06.036"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx443"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04510-8"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3582"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21750"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.578770"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728220903241658"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.24"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2013.03.020"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c02569"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4CC05138F"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112800"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2018.11.009"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.0c00532"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c01149"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2018.05.057"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00516"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c01659"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202500035"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.5c00033"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-018-0602-z"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CC08509B"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c02021"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmcr.2025.100276"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c02554"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202309459"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2025.01.021"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114544"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm400390r"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b01447"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2023.106546"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c00836"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c00761"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.9"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c00739"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c00939"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c00674"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja102758v"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm701079h"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC01485K"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.2c00288"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b01872"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202000351"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.0c00423"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.118295"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c01223"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.2c01317"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.70045"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2346"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.594"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27030715"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medidd.2025.100221"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1080\/17568919.2025.2533113"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.116972"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.118253"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.22101"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.116901"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CB00105A"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2023.10.001"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.118202"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2025.110449"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-60107-7"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2025.104376"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2374-x"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2025.117297"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2545-9"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.09.009"}],"container-title":["Medicinal Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.70052","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/med.70052","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.70052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T20:24:16Z","timestamp":1785961456000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/med.70052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,8]]},"references-count":166,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/med.70052"],"URL":"https:\/\/doi.org\/10.1002\/med.70052","archive":["Portico"],"relation":{},"ISSN":["0198-6325","1098-1128"],"issn-type":[{"value":"0198-6325","type":"print"},{"value":"1098-1128","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,8]]},"assertion":[{"value":"2025-12-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}