{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:49:35Z","timestamp":1791924575859,"version":"4.3.4"},"reference-count":340,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:00:00Z","timestamp":1778284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:00:00Z","timestamp":1778284800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medicinal Research Reviews"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Antibacterial agents remain vital for managing infectious diseases, yet the global escalation of antimicrobial resistance (AMR) continues to compromise their therapeutic effectiveness. Despite decades of discovery and chemical refinement, most recently developed antibacterials belong to existing structural classes, underscoring a pressing need for innovative molecular scaffolds and mechanisms of action. This review provides a comprehensive medicinal\u2010chemistry overview of major antibacterial classes, including \u03b2\u2010lactams, glycopeptides, tetracyclines, fluoroquinolones, macrolides, aminoglycosides, oxazolidinones, polymyxins, and lipopeptides. The discussion emphasizes their structural frameworks, key structure\u2013activity relationship (SAR) features, and the chemical strategies used to enhance potency, spectrum, and pharmacokinetic properties while counteracting bacterial resistance mechanisms. In addition, emerging developments in the antibacterial pipeline\u2014covering new, withdrawn, discontinued, and clinically advancing compounds (2000\u20132025)\u2014are highlighted to reflect the current state of innovation in antibiotic discovery. By integrating chemical, pharmacological, and developmental insights, this review aims to provide a clear and updated perspective on how medicinal chemistry continues to shape the design and evolution of antibacterial therapeutics in the face of rising resistance.<\/jats:p>","DOI":"10.1002\/med.70053","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T15:34:12Z","timestamp":1778340852000},"page":"1279-1329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Designing the Next Generation of Antibiotics: Structure, SAR, and Strategy in Medicinal Chemistry (2000\u20132025)"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8173-6073","authenticated-orcid":false,"given":"Ahmed A.","family":"Al\u2010Karmalawy","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Horus University\u2010Egypt New Damietta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Al\u2010Dakhil","sequence":"additional","affiliation":[{"name":"College of Science, Chemistry Department Imam Mohammad Ibn Saud Islamic University (IMSIU) Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada A.","family":"Ashour","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy Mansoura National University Gamasa Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3039-7646","authenticated-orcid":false,"given":"Tarek A.","family":"Yousef","sequence":"additional","affiliation":[{"name":"College of Science, Chemistry Department Imam Mohammad Ibn Saud Islamic University (IMSIU) Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar S.","family":"Mabrouk","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Pharmacy Ahram Canadian University (ACU) 6th October City, Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9445-3315","authenticated-orcid":false,"given":"Arwa Omar Al","family":"Khatib","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Al\u2010Ahliyya Amman University Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia S.","family":"Hawas","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Horus University\u2010Egypt New Damietta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2023.106108"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jscs.2022.101447"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-024-01041-1"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/bjbs.2023.11387"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202400931"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2025.1517772"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms13092115"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2023.135175"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29235777"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2022.2063282"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-818619-0.00133-7"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14081749"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00359"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-9504-2_2"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2RA04385H"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2025.2497466"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.4c00218"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1NJ02838C"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14570-z"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11091215"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11274-022-03334-0"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c02913"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/17568919.2025.2504331"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanmic.2024.07.010"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2016.02.004"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2018.0319"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2024.107110"},{"key":"e_1_2_10_29_1","first-page":"143","article-title":"Seasonal Variations in The Composition, Antioxidant, and Antimicrobial Activities of Zanthoxylum piperitum (L.) DC. \u2018Odorum\u2019 Leaves Essential Oil","volume":"67","author":"Fayek N.","year":"2024","journal-title":"Egyptian Journal of Chemistry"},{"key":"e_1_2_10_30_1","doi-asserted-by":"crossref","unstructured":"L.Abdulazeem S.Abdalkareem Jasim andW. J.Rajab \u201cWITHDRAWN: Anti\u2010Bacterial Activity of Gold Nanoparticles Against Two Type of Antibiotic Resistance Pathogenic Bacteria in Al\u2010Hilla City \u201d Materials Today: Proceedings (2021).","DOI":"10.1016\/j.matpr.2021.05.234"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2021.07.035"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26092671"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-021-00313-1"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.4c00115"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5NH00378D"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-021-00362-4"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20220062"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4MD00934G"},{"key":"e_1_2_10_39_1","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.2174\/0109298673362583250705102313","article-title":"Hybrids\/Conjugates\/Chimera Drugs\u2010Antimicrobial Hybrids: Antibiotics, Antifungals, Antituberculars, Antimalarials","volume":"33","author":"Nudelman A.","year":"2026","journal-title":"Current Medicinal Chemistry"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30132707"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-33-6009-9_54"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112829"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105662"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1MD00200G"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12111590"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867329666220620165429"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5RA04047G"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5MD00732A"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02137-22"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-1068-3"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15040463"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.1092556"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.1092556"},{"key":"e_1_2_10_54_1","doi-asserted-by":"crossref","unstructured":"In the Literature.Clinical Infectious Diseases67 no. 10 (2018):iii\u2010iv.","DOI":"10.1093\/cid\/ciy831"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2013.12.015"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.0131"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-017-0851-9"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113439"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14091818"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11030-023-10730-7"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28041762"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00184-00121"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.37201\/req\/s01.11.2021"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-013-0168-2"},{"key":"e_1_2_10_65_1","first-page":"215","article-title":"Ceftolozane\/Tazobactam: A Novel Antipseudomonal Cephalosporin and \u03b2\u2010Lactamase\u2010Inhibitor Combination","volume":"6","author":"Hong M. C.","year":"2013","journal-title":"Infection and Drug Resistance"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00564-19"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.2c00229"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2023.115945"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.12957\/bjhbs.2025.93437"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.2c00253"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408347.2024.2441428"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16030439"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12088-024-01273-y"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.02614-20"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11020259"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics17091142"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232213844"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.4c00989"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics17111426"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2017.05.011"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.3390\/org6030028"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-26078-0_4"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.2165\/11534440-000000000-00000"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.1c00367"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2025.2487163"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01101-08"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-021-01088-w"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks344"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr030103a"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01544-08"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-015-0505-8"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abo4736"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics1010001"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1093\/jacamr\/dlae127"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.2174\/0115734064263586231022135644"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c02677"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41429-025-00839-2"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a025387"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16020170"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom14101263"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28041762"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2022.2085881"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.18773\/austprescr.2021.035"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c01831"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28166018"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1097\/IM9.0000000000000181"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-019-00767-z"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-020-01257-4"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1800201"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-019-00843-4"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2016.4237"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-7646(02)00051-1"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202400295"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01947-01920"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom14070783"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcatb.2023.123226"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1671640"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-020-01358-0"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01318"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1086\/317490"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12941-016-0150-4"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202401936"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.001136"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12030628"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics14030221"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.888079"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15112554"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1177\/2472555218812657"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/jobm.70057"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2018.06.011"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2001.00049.x"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.001353"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1177\/1747493018778713"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.105924"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.2174\/15680266113136660223"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.616797"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2001.00049.x"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a027029"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1459"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkab435"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1206"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01326-12"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.8b00001"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm060732n"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2011.06330.x"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-020-4782-9"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-022-03446-4"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-023-01184-z"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.167766"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12941-024-00689-0"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.241"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab848"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2018.01.010"},{"issue":"3","key":"e_1_2_10_154_1","first-page":"242","article-title":"Tedizolid: A Comprehensive Review of Pharmacology, Clinical Applications and Future Directions in Antimicrobial Resistance","volume":"15","author":"Samajdar S. S.","year":"2025","journal-title":"Egyptian Journal of Infectious Endemic Diseases"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S84667"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1337"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200200528"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm020092y"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2015.1098617"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11030678"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00064-21"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2789"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2021.106325"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm900999h"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2018.03.028"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1189"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15030876"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz321"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics14010045"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000723"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1110"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2021.106408"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2022.08.019"},{"key":"e_1_2_10_174_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkad271"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00382"},{"key":"e_1_2_10_176_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c00780"},{"key":"e_1_2_10_177_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.202200114"},{"key":"e_1_2_10_178_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11091164"},{"key":"e_1_2_10_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2021.03.017"},{"key":"e_1_2_10_180_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2438"},{"key":"e_1_2_10_181_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz062"},{"key":"e_1_2_10_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2023.106856"},{"key":"e_1_2_10_183_1","first-page":"201","volume-title":"Advances in Parasitology","author":"Arg\u00fcello\u2010Garc\u00eda R.","year":"2020"},{"key":"e_1_2_10_184_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00526-23"},{"key":"e_1_2_10_185_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00997"},{"key":"e_1_2_10_186_1","doi-asserted-by":"publisher","DOI":"10.5863\/1551-6776-24.5.445"},{"key":"e_1_2_10_187_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.2137"},{"key":"e_1_2_10_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2021.106364"},{"key":"e_1_2_10_189_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm801374t"},{"key":"e_1_2_10_190_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00628"},{"key":"e_1_2_10_191_1","doi-asserted-by":"publisher","DOI":"10.3126\/bcj.v8i1.85493"},{"key":"e_1_2_10_192_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25040793"},{"key":"e_1_2_10_193_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a027110"},{"key":"e_1_2_10_194_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2020-0232"},{"key":"e_1_2_10_195_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01221-01220"},{"key":"e_1_2_10_196_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2864"},{"key":"e_1_2_10_197_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.15468"},{"key":"e_1_2_10_198_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00282-13"},{"key":"e_1_2_10_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2021.05.010"},{"key":"e_1_2_10_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2021.05.019"},{"key":"e_1_2_10_201_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm500312x"},{"key":"e_1_2_10_202_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2166"},{"key":"e_1_2_10_203_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.02388-02317"},{"key":"e_1_2_10_204_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmats.2020.594686"},{"key":"e_1_2_10_205_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym16121668"},{"key":"e_1_2_10_206_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-023-00993-0"},{"key":"e_1_2_10_207_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00203-026-04817-6"},{"key":"e_1_2_10_208_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics14040404"},{"key":"e_1_2_10_209_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-022-03029-7"},{"key":"e_1_2_10_210_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00343"},{"key":"e_1_2_10_211_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.06.004"},{"key":"e_1_2_10_212_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16030425"},{"key":"e_1_2_10_213_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.0c00178"},{"key":"e_1_2_10_214_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c00291"},{"key":"e_1_2_10_215_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.10.3118-3124.2002"},{"key":"e_1_2_10_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.07.075"},{"key":"e_1_2_10_217_1","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2009.2"},{"key":"e_1_2_10_218_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c00982"},{"key":"e_1_2_10_219_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15030264"},{"key":"e_1_2_10_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2025.123688"},{"key":"e_1_2_10_221_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.2c00598"},{"key":"e_1_2_10_222_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-63508-w"},{"key":"e_1_2_10_223_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm236"},{"key":"e_1_2_10_224_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.8b00315"},{"key":"e_1_2_10_225_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.5c00060"},{"key":"e_1_2_10_226_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28124628"},{"key":"e_1_2_10_227_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b01854"},{"key":"e_1_2_10_228_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00631"},{"key":"e_1_2_10_229_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01577-01519"},{"key":"e_1_2_10_230_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2024.116181"},{"key":"e_1_2_10_231_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciae108"},{"key":"e_1_2_10_232_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)00628-2"},{"key":"e_1_2_10_233_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkad060"},{"key":"e_1_2_10_234_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-023-00862-6"},{"key":"e_1_2_10_235_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkaa420"},{"key":"e_1_2_10_236_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35227-z"},{"key":"e_1_2_10_237_1","first-page":"1","volume-title":"Annual Reports in Medicinal Chemistry","author":"Manning D.","year":"2023"},{"key":"e_1_2_10_238_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14098"},{"key":"e_1_2_10_239_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c01201"},{"key":"e_1_2_10_240_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2023.12.009"},{"key":"e_1_2_10_241_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0910812"},{"key":"e_1_2_10_242_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(11)70374-7"},{"key":"e_1_2_10_243_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.4"},{"key":"e_1_2_10_244_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1313865"},{"key":"e_1_2_10_245_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1106753"},{"key":"e_1_2_10_246_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1901814"},{"key":"e_1_2_10_247_1","doi-asserted-by":"publisher","DOI":"10.1038\/35016103"},{"key":"e_1_2_10_248_1","doi-asserted-by":"crossref","unstructured":"Erratum Journal of Infectious Diseases217 no. 8 (2018): 1334.","DOI":"10.1093\/infdis\/jiy078"},{"key":"e_1_2_10_249_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30554-1"},{"key":"e_1_2_10_250_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00422-X"},{"key":"e_1_2_10_251_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24021634"},{"key":"e_1_2_10_252_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.0c00021"},{"key":"e_1_2_10_253_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2020.02.003"},{"key":"e_1_2_10_254_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41429-019-0225-5"},{"key":"e_1_2_10_255_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.02.026"},{"key":"e_1_2_10_256_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2018.02.026"},{"key":"e_1_2_10_257_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201600441"},{"key":"e_1_2_10_258_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.7b00196"},{"key":"e_1_2_10_259_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.7b00356"},{"key":"e_1_2_10_260_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz826"},{"key":"e_1_2_10_261_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.06.014"},{"issue":"2","key":"e_1_2_10_262_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.37201\/req\/s02.01.2022","article-title":"Resistance to Beta\u2010Lactams in Gram\u2010Negative Bacilli: Relevance and Potential Therapeutic Alternatives","volume":"35","author":"Garcia\u2010Bustos V.","year":"2022","journal-title":"Revista Espa\u00f1ola de Quimioterapia"},{"key":"e_1_2_10_263_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4SC04937C"},{"key":"e_1_2_10_264_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2023-0248"},{"key":"e_1_2_10_265_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.9b00159"},{"key":"e_1_2_10_266_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01239-01217"},{"key":"e_1_2_10_267_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11091251"},{"key":"e_1_2_10_268_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02893"},{"key":"e_1_2_10_269_1","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.02826-21"},{"key":"e_1_2_10_270_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0NP00061B"},{"key":"e_1_2_10_271_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706988"},{"key":"e_1_2_10_272_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06873-0"},{"key":"e_1_2_10_273_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-024-02137-x"},{"key":"e_1_2_10_274_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01016-18"},{"key":"e_1_2_10_275_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c02128"},{"key":"e_1_2_10_276_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.4c00308"},{"key":"e_1_2_10_277_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.02021-21"},{"key":"e_1_2_10_278_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkad022"},{"key":"e_1_2_10_279_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2023.09.003"},{"key":"e_1_2_10_280_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00250-00220"},{"key":"e_1_2_10_281_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-020-03129-6"},{"key":"e_1_2_10_282_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01985-21"},{"key":"e_1_2_10_283_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2023.09.011"},{"key":"e_1_2_10_284_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00037-09"},{"key":"e_1_2_10_285_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02056-4"},{"key":"e_1_2_10_286_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-025-03800-7"},{"key":"e_1_2_10_287_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2022.11.027"},{"key":"e_1_2_10_288_1","doi-asserted-by":"publisher","DOI":"10.1002\/wcms.70004"},{"key":"e_1_2_10_289_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30235-9"},{"issue":"2","key":"e_1_2_10_290_1","first-page":"134","article-title":"Ridinilazole: A Novel Antimicrobial for Clostridium difficile Infection","volume":"32","author":"Cho J. C.","year":"2019","journal-title":"Annals of Gastroenterology"},{"key":"e_1_2_10_291_1","doi-asserted-by":"publisher","DOI":"10.1111\/lam.13664"},{"key":"e_1_2_10_292_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00349-23"},{"key":"e_1_2_10_293_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2021-0129"},{"key":"e_1_2_10_294_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2019.04.004"},{"key":"e_1_2_10_295_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.932688"},{"key":"e_1_2_10_296_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw490"},{"key":"e_1_2_10_297_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)00017-7"},{"key":"e_1_2_10_298_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1R435"},{"key":"e_1_2_10_299_1","first-page":"1","volume-title":"Ketolide Antibiotics: Will They Ever be Used for Community\u2010Acquired Pneumonia?","author":"Metersky M. L.","year":"2017"},{"key":"e_1_2_10_300_1","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2011.44"},{"key":"e_1_2_10_301_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.30.3.290"},{"key":"e_1_2_10_302_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky425"},{"key":"e_1_2_10_303_1","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2013.86"},{"key":"e_1_2_10_304_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens14060525"},{"key":"e_1_2_10_305_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.1c01858"},{"key":"e_1_2_10_306_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.01257-23"},{"key":"e_1_2_10_307_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-022-01832-x"},{"key":"e_1_2_10_308_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics14010017"},{"key":"e_1_2_10_309_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543780903505092"},{"key":"e_1_2_10_310_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6MD00232C"},{"key":"e_1_2_10_311_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp160934"},{"key":"e_1_2_10_312_1","doi-asserted-by":"publisher","DOI":"10.4137\/PMC.S14459"},{"key":"e_1_2_10_313_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00663-10"},{"key":"e_1_2_10_314_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115239"},{"key":"e_1_2_10_315_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.0c00041"},{"key":"e_1_2_10_316_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10121506"},{"key":"e_1_2_10_317_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4572"},{"key":"e_1_2_10_318_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8020191"},{"key":"e_1_2_10_319_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b01159"},{"key":"e_1_2_10_320_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.20019"},{"key":"e_1_2_10_321_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01184-01117"},{"key":"e_1_2_10_322_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics13090810"},{"key":"e_1_2_10_323_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1157437"},{"key":"e_1_2_10_324_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13081289"},{"key":"e_1_2_10_325_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb13030086"},{"key":"e_1_2_10_326_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202310040"},{"key":"e_1_2_10_327_1","doi-asserted-by":"publisher","DOI":"10.2174\/0115680266350153250121072651"},{"key":"e_1_2_10_328_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c01496"},{"key":"e_1_2_10_329_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-022-00414-6"},{"key":"e_1_2_10_330_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-030920-011143"},{"key":"e_1_2_10_331_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2014.116"},{"key":"e_1_2_10_332_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c02562"},{"key":"e_1_2_10_333_1","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2023.3271611"},{"key":"e_1_2_10_334_1","doi-asserted-by":"publisher","DOI":"10.1080\/07388551.2026.2628602"},{"key":"e_1_2_10_335_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202510355"},{"key":"e_1_2_10_336_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules18033502"},{"key":"e_1_2_10_337_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/9967591"},{"key":"e_1_2_10_338_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mne.2024.100239"},{"key":"e_1_2_10_339_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2023.102347"},{"key":"e_1_2_10_340_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-025-01075-4"},{"key":"e_1_2_10_341_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781394234196.ch5"}],"container-title":["Medicinal Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.70053","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/med.70053","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.70053","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T20:24:32Z","timestamp":1785961472000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/med.70053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,9]]},"references-count":340,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/med.70053"],"URL":"https:\/\/doi.org\/10.1002\/med.70053","archive":["Portico"],"relation":{},"ISSN":["0198-6325","1098-1128"],"issn-type":[{"value":"0198-6325","type":"print"},{"value":"1098-1128","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,9]]},"assertion":[{"value":"2025-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}