{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:50:55Z","timestamp":1791204655033,"version":"4.2.0"},"reference-count":226,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["CE200100012"],"award-info":[{"award-number":["CE200100012"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP250102295"],"award-info":[{"award-number":["DP250102295"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medicinal Research Reviews"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria\u2010associated deaths reported in 2024. Most mortality is due to infection by\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    parasites, with the highest burden occurring in Sub\u2010Saharan Africa. Malaria eradication is a global priority; however, progress has been hampered by the lack of broadly applicable and highly effective vaccines and by parasite drug resistance. To address drug resistance, the discovery of drugs with novel modes of action is crucial. Histone\/lysine deacetylases (HDACs) are enzymes that control the posttranslational modification of lysine acetylation on histone and non\u2010histone proteins. Due to their essential roles in regulating key processes in\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    parasites, including transcriptional and developmental control, HDACs are prospective drug targets for malaria. Here, the potential of HDAC inhibitors as antimalarial drug leads is reviewed, including an assessment of antiplasmodial structure\u2010activity relationships for more than 750 hydroxamic acids with published in vitro activity against\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    . These comparative data provide unprecedented insights into potency, selectivity and physicochemical properties that can help to guide investigations of this chemotype as drug leads for malaria and other parasitic diseases.\n                  <\/jats:p>","DOI":"10.1002\/med.70055","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T12:18:39Z","timestamp":1779797919000},"page":"1477-1498","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9059-7020","authenticated-orcid":false,"given":"Wisam A.","family":"Dawood","sequence":"first","affiliation":[{"name":"Institute for Biomedicine and Glycomics Griffith University Southport Queensland Australia"},{"name":"School of Environment and Sciences Griffith University Nathan Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1516-8415","authenticated-orcid":false,"given":"Jacinta R.","family":"Macdonald","sequence":"additional","affiliation":[{"name":"Institute for Biomedicine and Glycomics Griffith University Southport Queensland Australia"},{"name":"School of Environment and Sciences Griffith University Nathan Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Anzenhofer","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr pharmazeutische und medizinische Chemie Heinrich\u2010Heine Universit\u00e4t  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7011-3850","authenticated-orcid":false,"given":"Tina S.","family":"Skinner\u2010Adams","sequence":"additional","affiliation":[{"name":"Institute for Biomedicine and Glycomics Griffith University Southport Queensland Australia"},{"name":"School of Environment and Sciences Griffith University Nathan Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Reid","sequence":"additional","affiliation":[{"name":"Centre for Chemistry and Drug Discovery, Institute for Molecular Bioscience University of Queensland Brisbane Queensland Australia"},{"name":"Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, Institute for Molecular Bioscience University of Queensland Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9474-4224","authenticated-orcid":false,"given":"Thomas","family":"Kurz","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr pharmazeutische und medizinische Chemie Heinrich\u2010Heine Universit\u00e4t  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Fairlie","sequence":"additional","affiliation":[{"name":"Centre for Chemistry and Drug Discovery, Institute for Molecular Bioscience University of Queensland Brisbane Queensland Australia"},{"name":"Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, Institute for Molecular Bioscience University of Queensland Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1591-8979","authenticated-orcid":false,"given":"Katherine T.","family":"Andrews","sequence":"additional","affiliation":[{"name":"Institute for Biomedicine and Glycomics Griffith University Southport Queensland Australia"},{"name":"School of Environment and Sciences Griffith University Nathan Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organisation World Malaria Report 2025 in https:\/\/www.who.int\/teams\/global\u2010malaria\u2010programme\/reports\/world\u2010malaria\u2010report\u20102025 2025."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(24)00141\u20105"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","unstructured":"R.Shretta J.Liu C.Cotter et al. Malaria Elimination and Eradication in:K. K.Holmes S.Bertozzi B. R.Bloom P.Jha(Eds.) Major Infectious Diseases Washington (DC) 2017.","DOI":"10.1596\/978-1-4648-0524-0_ch12"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010015\u20100384\u20106"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111983"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)01249\u20107"},{"key":"e_1_2_9_8_1","unstructured":"World Health Organisation Global Malaria Programme Operational Strategy 2024\u20102030. Geneva: World Health Organization. Licence: CC BY\u2010NC\u2010SA 3.0 IGO. in https:\/\/www.who.int\/publications\/i\/item\/9789240090149 2024."},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071\u2010024\u201006165\u20100"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010025\u201002246\u20103"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a025486"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40101\u2010020\u201000251\u20109"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010595"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1011157"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a025452"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2101746"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201033873\u2010x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010024\u201001008\u20102"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475\u20102875\u201012\u201011"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1102287"},{"key":"e_1_2_9_21_1","unstructured":"World Health Organisation WHO Director\u2010General's opening remarks at the SAGE media briefing \u2013 2 October 2023(2023) https:\/\/www.who.int\/news\u2010room\/speeches\/item\/who\u2010director\u2010general\u2010s\u2010opening\u2010remarks\u2010at\u2010the\u2010sage\u2010media\u2010briefing\u2010\u2010\u20102\u2010october\u20102023."},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(24)00214\u20107"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0805011"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa628"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw388"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(23)00209\u20108"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.6138"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586\u2010025\u201003690\u20105"},{"key":"e_1_2_9_29_1","unstructured":"World Health Organisation Strategy to Respond to Antimalarial Drug Resistance in Africa in https:\/\/www.who.int\/publications\/i\/item\/9789240060265 2022."},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0000005"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1087025"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.06.014"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010micro\u2010032521\u2010041554"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936\u2010024\u201004855\u20109"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276\u2010020\u20100382\u20104"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/286164"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05913"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2016.59"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2005.09.010"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2023.02.007"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.351444.123"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1450440"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010024\u201004115\u20106"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020\u2010021\u201000375\u20103"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000737"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031847"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421\u2010020\u201000215\u20104"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c02104"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20021321"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2485"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.4161\/epi.3.1.5736"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20070140"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210620"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn814"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aap7847"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936\u2010021\u201003865\u20101"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.01.037"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000084"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20102836(05)80360\u20102"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14376"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2009.06.012"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2022.111458"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.18.5418"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1128\/msphere.00329\u201022"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.01.036"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161212801327257"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2011.97"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26185711"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202100176"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae1082"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2021.08.006"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2016.12.005"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0166\u20106851(98)00177\u20107"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.02377\u201023"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.02721\u201013"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw536"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2019.01.008"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102164\u201012\u2010391"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201020805\u2010w"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16023915"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2004.04.012"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2008.03.005"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00757\u201007"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/43710"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmgm.2015.10.006"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.09.096"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201007487\u2010w"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706487104"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2005.09.065"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a018713"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2014.07.006"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky926"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16121639"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40203\u2010021\u201000077\u2010y"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.02.075"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.03.007"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2005.05.007"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature24280"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864\u2010015\u20102320\u20108"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1079"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi062188q"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1223"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M707362200"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M803514200"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115907"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.01220\u201020"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/35073015"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbior.2020.100782"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1128\/ec.00409\u201007"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1586\/eri.12.100"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.08.073"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104462"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2017.1417274"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2015.05.004"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.02523\u201019"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b01194"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010022\u201001221\u20106"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18071414"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159x17666181227165722"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13143409"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.687362"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41573\u2010024\u201000066\u20108"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.103184"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.61602"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.23.13143"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0020\u20107519(00)00043\u20106"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00030\u201012"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.05.050"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936\u2010020\u201003421\u20103"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep03743"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.113065"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201059298\u20104"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40794\u2010022\u201000185\u20103"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40121\u2010022\u201000713\u2010w"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936\u2010022\u201004339\u20108"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936\u2010022\u201004131\u20108"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01220\u201010"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2004.03.006"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.21\u20100796"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq249"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201013412\u2010x"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00079\u201012"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.4.1435\u20101436.2004"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm801654y"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2014.12.051"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.Ccr\u201009\u20100547"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.1c00355"},{"key":"e_1_2_9_148_1","unstructured":"Chemical Abstracts Service CAS SciFinder in American Chemical Society (ACS)2024."},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac956"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1075"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-78246-9_38"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589\u2010022\u201001015\u20105"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1107\/s2053230x25007447"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1718823114"},{"key":"e_1_2_9_155_1","unstructured":"MMV Target Product Profiles & Target Candidate Profiles Website 2023 https:\/\/www.mmv.org\/research\u2010development\/information\u2010scientists\/target\u2010product\u2010profiles\u2010target\u2010candidate\u2010profiles(13 April2026)."},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00729\u201008"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00439\u201008"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01993"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2020.12.023"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.09.018"},{"key":"e_1_2_9_161_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201800808"},{"key":"e_1_2_9_162_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja102758v"},{"key":"e_1_2_9_163_1","doi-asserted-by":"publisher","DOI":"10.1039\/c5cc10301k"},{"key":"e_1_2_9_164_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc\u20102016\u20100215"},{"key":"e_1_2_9_165_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00821"},{"key":"e_1_2_9_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201047959\u2010z"},{"key":"e_1_2_9_167_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm701606b"},{"key":"e_1_2_9_168_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.5b00468"},{"key":"e_1_2_9_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2020.10.010"},{"key":"e_1_2_9_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2025.100608"},{"key":"e_1_2_9_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-820546-4.00014-3"},{"key":"e_1_2_9_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0169\u2010409x(00)00129\u20100"},{"key":"e_1_2_9_173_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1MD00093D"},{"key":"e_1_2_9_174_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201000087"},{"key":"e_1_2_9_175_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589\u2010023\u201001496\u2010y"},{"key":"e_1_2_9_176_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00838"},{"key":"e_1_2_9_177_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.03324\u201014"},{"key":"e_1_2_9_178_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936\u2010024\u201005186\u20105"},{"key":"e_1_2_9_179_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201600347"},{"key":"e_1_2_9_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2024.108716"},{"key":"e_1_2_9_181_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201300469"},{"key":"e_1_2_9_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2009.10.042"},{"key":"e_1_2_9_183_1","doi-asserted-by":"publisher","DOI":"10.2217\/epi.11.12"},{"key":"e_1_2_9_184_1","doi-asserted-by":"publisher","DOI":"10.2217\/epi.10.59"},{"key":"e_1_2_9_185_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408732102"},{"key":"e_1_2_9_186_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20104614\u20100254\u20101_14"},{"key":"e_1_2_9_187_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163690"},{"key":"e_1_2_9_188_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euaf076"},{"key":"e_1_2_9_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.116782"},{"key":"e_1_2_9_190_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.70071"},{"key":"e_1_2_9_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2024.117985"},{"key":"e_1_2_9_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.117045"},{"key":"e_1_2_9_193_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102003\u201001\u20100233"},{"key":"e_1_2_9_194_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15030333"},{"key":"e_1_2_9_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2025.108312"},{"key":"e_1_2_9_196_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248\u2010016\u20109876\u20103"},{"key":"e_1_2_9_197_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon\u20102016\u20100526"},{"key":"e_1_2_9_198_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2005.02.188"},{"key":"e_1_2_9_199_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280\u2010013\u20102220\u2010z"},{"key":"e_1_2_9_200_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.734"},{"key":"e_1_2_9_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2013.10.027"},{"key":"e_1_2_9_202_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201700360"},{"key":"e_1_2_9_203_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16144"},{"key":"e_1_2_9_204_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuz005"},{"key":"e_1_2_9_205_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201020629\u20108"},{"key":"e_1_2_9_206_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2022.01.011"},{"key":"e_1_2_9_207_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010023\u201000772\u20109"},{"key":"e_1_2_9_208_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936\u2010016\u20101675\u2010x"},{"key":"e_1_2_9_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.118525"},{"key":"e_1_2_9_210_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01275"},{"key":"e_1_2_9_211_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.10.041"},{"key":"e_1_2_9_212_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c02373"},{"key":"e_1_2_9_213_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.1c01988"},{"key":"e_1_2_9_214_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtumed.2023.11.006"},{"key":"e_1_2_9_215_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiolchem.2019.03.010"},{"key":"e_1_2_9_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtumed.2023.04.005"},{"key":"e_1_2_9_217_1","doi-asserted-by":"publisher","DOI":"10.2174\/156802609788085313"},{"key":"e_1_2_9_218_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b01595"},{"key":"e_1_2_9_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dmd.2025.100151"},{"key":"e_1_2_9_220_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph18040577"},{"key":"e_1_2_9_221_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacsau.4c00828"},{"key":"e_1_2_9_222_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.4c00031"},{"key":"e_1_2_9_223_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475\u20102875\u201011\u2010292"},{"key":"e_1_2_9_224_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.1c00341"},{"key":"e_1_2_9_225_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.16.6.710"},{"key":"e_1_2_9_226_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.48.5.1803\u20101806.2004"},{"key":"e_1_2_9_227_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00661\u201023"}],"container-title":["Medicinal Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.70055","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/med.70055","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.70055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:53:33Z","timestamp":1791201213000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/med.70055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,26]]},"references-count":226,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1002\/med.70055"],"URL":"https:\/\/doi.org\/10.1002\/med.70055","archive":["Portico"],"relation":{},"ISSN":["0198-6325","1098-1128"],"issn-type":[{"value":"0198-6325","type":"print"},{"value":"1098-1128","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,26]]},"assertion":[{"value":"2025-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}