{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:50:51Z","timestamp":1791204651072,"version":"4.2.0"},"reference-count":243,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273167"],"award-info":[{"award-number":["82273167"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medicinal Research Reviews"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Influenza A virus (IAV) continues to be one of the most serious health burdens causing widespread illness and mortality. Limited efficacy and reduced susceptibility of available drugs and vaccines to the emergence of resistant strains have spurred the pursuit of alternative treatment strategies. Hemagglutinin (HA), essential for viral attachment and membrane fusion in the first step of the virus infection cycle, has emerged as an attractive target. Over the past few decades, HA has garnered considerable attention, and significant progress has been achieved in the discovery of HA modulators, even though no anti\u2010IAV drugs targeting HA have been approved by the FDA. This article provides a comprehensive overview of the current landscape of HA inhibitors and degraders, mainly focusing on the systematic structure\u2013activity relationship (SAR) exploration of both synthetic and natural product (NP)\u2010derived small molecules endowed with abundant structural frameworks, together with a brief introduction of different binding modes based on cocrystal structures of IAV HAs and HA inhibitors. We anticipate that this review will serve as practical guidance for the development of urgently needed, more effective, and structurally innovative HA\u2010targeting drugs capable of addressing the escalating challenge of drug resistance.<\/jats:p>","DOI":"10.1002\/med.70081","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T10:39:02Z","timestamp":1784284742000},"page":"1958-1989","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Current Development of Small Molecules Against Influenza A Virus by Targeting Hemagglutinin"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3029-4284","authenticated-orcid":false,"given":"Dandan","family":"Xu","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy Jiangsu Ocean University Lianyungang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinpeng","family":"Gu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy Jiangsu Ocean University Lianyungang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Yu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy Jiangsu Ocean University Lianyungang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Dou","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy Jiangsu Ocean University Lianyungang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiling","family":"Cao","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy Jiangsu Ocean University Lianyungang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingdao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy Jiangsu Ocean University Lianyungang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanzhu","family":"Lu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy Jiangsu Ocean University Lianyungang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianjiang","family":"Cai","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy Jiangsu Ocean University Lianyungang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1569-2604","authenticated-orcid":false,"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy Jiangsu Ocean University Lianyungang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"World Health Organization The Burden of Influenza(WHO 2024) https:\/\/www.who.int\/news\u2010room\/feature\u2010stories\/detail\/the\u2010burden\u2010of\u2010influenza."},{"key":"e_1_2_13_3_1","unstructured":"World Health Organization Global Influenza Strategy 2019\u20132030(WHO 2019) https:\/\/iris.who.int\/handle\/10665\/311184."},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/v11050458"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2024.05.018"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwaf471"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44185\u2010025\u201000114\u20105"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.118"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114189"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010019\u201001176\u2010z"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2023.105785"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1007071107"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495\u2010199958040\u201000016"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495\u2010200161020\u201000011"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010018\u20100981\u20108"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010018\u20100899\u20101"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0902548106"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc.1003749"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27870"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560\u20107917.Es.2019.24.12.1900170"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2020.1831471"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21289"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14060587"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/v15040902"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.2174\/0113895575401074250923075239"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.37349\/eds.2024.00037"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.984"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986708784049658"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2014.04.006"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201022964\u2010w"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan0516"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2426554122"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1093155"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.657"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3346"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/333426a0"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010020\u20102333\u20106"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2208011119"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2020.1856814"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.17071"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1801999115"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202006145"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abd3803"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja410918a"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00063a007"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.11.8808\u20108820.1997"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0807142105"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/prot.22830"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2015.01.009"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171491"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1205669"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1222908"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1126\/science"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2006893117"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202000724"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2020.1871414"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00042"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aau8408"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c02013"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278\u20106915(86)90289\u20109"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.6b00046"},{"key":"e_1_2_13_66_1","unstructured":"F. A.Trofimov N. G.Tsyshkova N. S.Bogdanova et al. \u201cIndole Derivative Having Antiviral Interferon\u2010Inducing and Immunomodulatory Effects \u201d US5198552A (1993)."},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2008.10.009"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.08.021"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.05.005"},{"key":"e_1_2_13_70_1","unstructured":"P.GongandY.Zhao \u201c5\u2010Hydroxyindole\u20103\u2010carboxylate Derivatives and Uses Thereof \u201d US2008249155A1 (2008)."},{"key":"e_1_2_13_71_1","unstructured":"V. J.Grigorievich T. N.Gavrilovna R. R.Akhmetdzhanovich et al. \u201c5\u2010Hydroxy\u20104\u2010aminomethyl\u20101\u2010cyclohexane or (cycloheptyl)\u2010\u22123\u2010alkoxycarbonyl Indole Derivatives Pharmaceutically Acceptable Antiviral Salts Thereof and a Method for the Production Thereof \u201d US2011144353A1 (2011)."},{"key":"e_1_2_13_72_1","unstructured":"J. G.Verkhovsky N. G.Tsyshkova R. A.Roziev et al. \u201c5\u2010Substituted Indol\u20103\u2010carboxylic Acid Derivatives Exhibiting Antiviral Activity a Method for the Production and Use Thereof \u201d US2011065919A1 (2011)."},{"key":"e_1_2_13_73_1","unstructured":"J.Liu L.Kuang J.Pan andY.Liu \u201cPreparation of Arbidol Analogs or Its Salt Useful in the Treatment of Flu \u201d CN104193669A (2014)."},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1617020114"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2017.06.074"},{"key":"e_1_2_13_76_1","unstructured":"I. A.Wilson D. W.Wolan Z. V. F.Wright et al. \u201cArbidol Analogs With Improved Influenza Hemagglutinin Potency \u201d WO2018112128A1 (2018)."},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.2c00178"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c03093"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.5c13080"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo201789k"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c00312"},{"key":"e_1_2_13_82_1","unstructured":"D.Li G.Yu T.Zhu et al. \u201cIndole Alkaloid Compound and Preparation Method and Use Thereof \u201d WO2017107897A1 (2017)."},{"key":"e_1_2_13_83_1","unstructured":"D.Li G.Yu andT.Zhu et.al \u201cA Kind of Indole Alkaloids Compound and Its Preparation Method and Application \u201d CN106892854A (2017)."},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115615"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c03787"},{"key":"e_1_2_13_86_1","unstructured":"J. V. P.Bv \u201cPiperazine Derivatives for Influenza Virus Inhibitions \u201d US2020010459A1 (2020)."},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113591"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1725"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114906"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00898\u201016"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00878\u201019"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2310677121"},{"key":"e_1_2_13_93_1","unstructured":"D. W.Wolan L. A.Wilson Y.Yao et al. \u201cMorpholine Derivatives as Inhibitors of Influenza Hemagglutinin \u201d WO2021202600A1 (2021)."},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c02937"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1996.0628"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.5.4062\u20104070.1997"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960\u2010894X(99)00361\u20103"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0960\u2010894x(00)00335\u20108"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.73.3.1785\u20101794.1999"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960\u2010894X(01)00459\u20100"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0960\u2010894x(02)00761\u20108"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1021\/ml2000627"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.73.1.140\u2010151.1999"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.04.013"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2012.08.041"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041956"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c01357"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2020.104782"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b01900"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adk9004"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01225\u201013"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.572974"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.6b00194"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.02326\u201015"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00908"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00304"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2015.11.024"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15030301"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1021\/id500022h"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.04.141"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.02325\u201009"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1080\/10426507.2014.965819"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.104958"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201900028"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2019.115130"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.70080"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2012.09.064"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2015.06.004"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2018.08.011"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2019.126745"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1039\/c6md00657d"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2021.128465"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2021.105013"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.117679"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c01329"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2503899122"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2026.111150"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112223"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022\u20101317\u201067\u20106\u20101115"},{"issue":"6","key":"e_1_2_13_142_1","first-page":"501","article-title":"Antiviral Activity of Norakin (Triperiden) and Related Anticholinergic Antiparkinsonism Drugs","volume":"28","author":"Presber H. W.","year":"1984","journal-title":"Acta Virologica"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.46.1039"},{"key":"e_1_2_13_144_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.47.28"},{"key":"e_1_2_13_145_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.49.379"},{"key":"e_1_2_13_146_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm1012374"},{"key":"e_1_2_13_147_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c00134"},{"key":"e_1_2_13_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2022.10.019"},{"key":"e_1_2_13_149_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c00319"},{"key":"e_1_2_13_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.06.006"},{"key":"e_1_2_13_151_1","doi-asserted-by":"publisher","DOI":"10.1021\/ml500108s"},{"key":"e_1_2_13_152_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm500598u"},{"key":"e_1_2_13_153_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1216526110"},{"key":"e_1_2_13_154_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00650\u201009"},{"key":"e_1_2_13_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.12.013"},{"key":"e_1_2_13_156_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.4c00502"},{"key":"e_1_2_13_157_1","doi-asserted-by":"publisher","DOI":"10.3390\/v12050581"},{"key":"e_1_2_13_158_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201087845\u20100"},{"key":"e_1_2_13_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401\u2010024\u201001331\u20107"},{"key":"e_1_2_13_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.03.064"},{"key":"e_1_2_13_161_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0906849106"},{"key":"e_1_2_13_162_1","doi-asserted-by":"publisher","DOI":"10.5246\/jcps"},{"key":"e_1_2_13_163_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c02736"},{"key":"e_1_2_13_164_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21707"},{"key":"e_1_2_13_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2003.10.006"},{"key":"e_1_2_13_166_1","doi-asserted-by":"publisher","DOI":"10.1021\/np900749b"},{"key":"e_1_2_13_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2013.12.058"},{"key":"e_1_2_13_168_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm900275m"},{"key":"e_1_2_13_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.02.029"},{"key":"e_1_2_13_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2012.04.022"},{"key":"e_1_2_13_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.04.061"},{"key":"e_1_2_13_172_1","doi-asserted-by":"publisher","DOI":"10.3390\/v12020225"},{"key":"e_1_2_13_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2017.06.025"},{"key":"e_1_2_13_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral"},{"key":"e_1_2_13_175_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA02677F"},{"key":"e_1_2_13_176_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm5014067"},{"key":"e_1_2_13_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111622"},{"key":"e_1_2_13_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.116977"},{"key":"e_1_2_13_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2026.118566"},{"key":"e_1_2_13_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2019.115147"},{"key":"e_1_2_13_181_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.c19\u201000485"},{"key":"e_1_2_13_182_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm_00000053"},{"key":"e_1_2_13_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2012.02.022"},{"key":"e_1_2_13_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2009.09.015"},{"key":"e_1_2_13_185_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000174023.73472.29"},{"key":"e_1_2_13_186_1","first-page":"1011","volume-title":"In Vivo","author":"Lopez B. S.","year":"2009"},{"key":"e_1_2_13_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.01.005"},{"key":"e_1_2_13_188_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6MD00292G"},{"key":"e_1_2_13_189_1","doi-asserted-by":"publisher","DOI":"10.1039\/c7md00245a"},{"key":"e_1_2_13_190_1","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2016.1120670"},{"key":"e_1_2_13_191_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389450117666160112113930"},{"key":"e_1_2_13_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.12.006"},{"key":"e_1_2_13_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2013.11.012"},{"key":"e_1_2_13_194_1","doi-asserted-by":"publisher","DOI":"10.3390\/v10090471"},{"key":"e_1_2_13_195_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0171936"},{"key":"e_1_2_13_196_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054967"},{"key":"e_1_2_13_197_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1998.9273"},{"key":"e_1_2_13_198_1","doi-asserted-by":"publisher","DOI":"10.1021\/ml500533x"},{"key":"e_1_2_13_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0944\u20107113(99)80012\u20109"},{"key":"e_1_2_13_200_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2650090804"},{"key":"e_1_2_13_201_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.32.1385"},{"key":"e_1_2_13_202_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2018.9281"},{"key":"e_1_2_13_203_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178226"},{"key":"e_1_2_13_204_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2021.105149"},{"key":"e_1_2_13_205_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007050050552"},{"key":"e_1_2_13_206_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743\u2010422x\u201010\u2010118"},{"key":"e_1_2_13_207_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1018983715982"},{"key":"e_1_2_13_208_1","doi-asserted-by":"publisher","DOI":"10.1211\/0022357001777225"},{"key":"e_1_2_13_209_1","doi-asserted-by":"publisher","DOI":"10.1021\/cb200332k"},{"key":"e_1_2_13_210_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348\u20100421.2000"},{"key":"e_1_2_13_211_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules"},{"key":"e_1_2_13_212_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139236"},{"key":"e_1_2_13_213_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2018.04.057"},{"key":"e_1_2_13_214_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2020.127677"},{"key":"e_1_2_13_215_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389200219666180220095236"},{"key":"e_1_2_13_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2009.03.002"},{"key":"e_1_2_13_217_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.01.071"},{"key":"e_1_2_13_218_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.01.058"},{"key":"e_1_2_13_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2014.04.057"},{"key":"e_1_2_13_220_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.7b01567"},{"key":"e_1_2_13_221_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535\u2010019\u201001643\u20100"},{"key":"e_1_2_13_222_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf040095e"},{"key":"e_1_2_13_223_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023"},{"key":"e_1_2_13_224_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2009.09.011"},{"key":"e_1_2_13_225_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12503"},{"key":"e_1_2_13_226_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.02.101"},{"key":"e_1_2_13_227_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11010039"},{"key":"e_1_2_13_228_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2005.06.010"},{"key":"e_1_2_13_229_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2007.07.001"},{"key":"e_1_2_13_230_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166\u20103542(93)90008\u20107"},{"key":"e_1_2_13_231_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2012.04.001"},{"key":"e_1_2_13_232_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2023.105940"},{"key":"e_1_2_13_233_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres"},{"key":"e_1_2_13_234_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232113112"},{"key":"e_1_2_13_235_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252212426"},{"key":"e_1_2_13_236_1","doi-asserted-by":"publisher","DOI":"10.1080\/08927022.2010.543973"},{"key":"e_1_2_13_237_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2011.10508605"},{"key":"e_1_2_13_238_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.02.006"},{"key":"e_1_2_13_239_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26062819"},{"key":"e_1_2_13_240_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol"},{"key":"e_1_2_13_241_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines11020270"},{"key":"e_1_2_13_242_1","doi-asserted-by":"publisher","DOI":"10.15212\/amm\u20102023\u20100019"},{"key":"e_1_2_13_243_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20102836(94)90027\u20102"},{"key":"e_1_2_13_244_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1473\u20103099(14)70821\u20107"}],"container-title":["Medicinal Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.70081","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/med.70081","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.70081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:52:11Z","timestamp":1791201131000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/med.70081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,17]]},"references-count":243,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1002\/med.70081"],"URL":"https:\/\/doi.org\/10.1002\/med.70081","archive":["Portico"],"relation":{},"ISSN":["0198-6325","1098-1128"],"issn-type":[{"value":"0198-6325","type":"print"},{"value":"1098-1128","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,17]]},"assertion":[{"value":"2025-11-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}