{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:03:00Z","timestamp":1785250980065,"version":"3.55.0"},"reference-count":253,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["AN309\/11\u20101"],"award-info":[{"award-number":["AN309\/11\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["CA21110"],"award-info":[{"award-number":["CA21110"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["101034412"],"award-info":[{"award-number":["101034412"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medicinal Research Reviews"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA. One of the most promising medication modalities is through the clearance of cells that are cell cycle arrested but resistant to apoptosis, termed senescent cells. Additionally, these cells are also resistant to alternative programmed cell death modes, such as ferroptosis and pyroptosis. Senescent cells tend to accumulate with age due to increasing cellular and genetic damage. These cells can release inflammatory factors and signaling molecules termed senescence\u2010associated secretory phenotype (SASP). In addition to triggering an inflammatory milieu in joints, SASP can also induce senescence in other cells through autocrine signaling. It has been shown via in vitro and in vivo tests that clearance of senescent cells through a class of drugs known as senolytics, or neutralization of SASP with senomorphics, can improve OA pathogenesis. Following these results, several clinical trials have been conducted to evaluate the efficacy of senotherapeutics against knee OA. Yet there remains a need for a comprehensive assessment of safety and optimization of senotherapeutic treatment regimens for knee OA. To this end, a better understanding of molecular mechanisms behind chondrocyte senescence and knee OA pathogenesis is necessary. Identification of novel compounds that can specifically target chondrocyte senescence pathways can assist in developing more effective therapies against OA.<\/jats:p>","DOI":"10.1002\/med.70082","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:46:20Z","timestamp":1785249980000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Senotherapeutics for Knee Osteoarthritis"],"prefix":"10.1002","author":[{"given":"Ezgi","family":"Duman","sequence":"first","affiliation":[{"name":"Lehrstuhl f\u00fcr Regeneration Muskuloskelettaler Gewebe und Lehrstuhl f\u00fcr Orthop\u00e4die, Orthop\u00e4dische Klinik K\u00f6nig\u2010Ludwig\u2010Haus, Universit\u00e4t W\u00fcrzburg W\u00fcrzburg Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7647-3769","authenticated-orcid":false,"given":"Girish","family":"Pattappa","sequence":"additional","affiliation":[{"name":"Lehrstuhl f\u00fcr Regeneration Muskuloskelettaler Gewebe und Lehrstuhl f\u00fcr Orthop\u00e4die, Orthop\u00e4dische Klinik K\u00f6nig\u2010Ludwig\u2010Haus, Universit\u00e4t W\u00fcrzburg W\u00fcrzburg Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Pann","sequence":"additional","affiliation":[{"name":"Labor f\u00fcr Experimentelle Unfallchirurgie, Klinik und Poliklinik f\u00fcr Unfallchirurgie, Universit\u00e4tsklinikum Regensburg Regensburg Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Reppenhagen","sequence":"additional","affiliation":[{"name":"Lehrstuhl f\u00fcr Regeneration Muskuloskelettaler Gewebe und Lehrstuhl f\u00fcr Orthop\u00e4die, Orthop\u00e4dische Klinik K\u00f6nig\u2010Ludwig\u2010Haus, Universit\u00e4t W\u00fcrzburg W\u00fcrzburg Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Rudert","sequence":"additional","affiliation":[{"name":"Lehrstuhl f\u00fcr Regeneration Muskuloskelettaler Gewebe und Lehrstuhl f\u00fcr Orthop\u00e4die, Orthop\u00e4dische Klinik K\u00f6nig\u2010Ludwig\u2010Haus, Universit\u00e4t W\u00fcrzburg W\u00fcrzburg Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Angele","sequence":"additional","affiliation":[{"name":"Labor f\u00fcr Experimentelle Unfallchirurgie, Klinik und Poliklinik f\u00fcr Unfallchirurgie, Universit\u00e4tsklinikum Regensburg Regensburg Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7588-1290","authenticated-orcid":false,"given":"Denitsa","family":"Docheva","sequence":"additional","affiliation":[{"name":"Lehrstuhl f\u00fcr Regeneration Muskuloskelettaler Gewebe und Lehrstuhl f\u00fcr Orthop\u00e4die, Orthop\u00e4dische Klinik K\u00f6nig\u2010Ludwig\u2010Haus, Universit\u00e4t W\u00fcrzburg W\u00fcrzburg Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"issue":"3","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.semarthrit.2013.07.003","article-title":"Health Economics in the Field of Osteoarthritis: An Expert's Consensus Paper From the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)","volume":"43","author":"Hiligsmann M.","year":"2013","journal-title":"Seminars in Arthritis and Rheumatism"},{"issue":"6","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.bbadis.2019.03.011","article-title":"Cartilage Biomechanics: A Key Factor for Osteoarthritis Regenerative Medicine","volume":"1865","author":"Mart\u00ednez\u2010Moreno D.","year":"2019","journal-title":"Biochimica et Biophysica Acta (BBA) \u2010 Molecular Basis of Disease"},{"issue":"5","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s10067-009-1352-3","article-title":"Osteoarthritis: Can Anti\u2010Cytokine Therapy Play a Role in Treatment?","volume":"29","author":"Calich A. 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