{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T09:04:09Z","timestamp":1784624649902,"version":"3.55.0"},"reference-count":154,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22277083"],"award-info":[{"award-number":["22277083"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medicinal Research Reviews"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Monoacylglycerol lipase (MAGL), a member of the endocannabinoid system (ECS), plays a crucial role in physiological processes such as regulating the signal transduction of the ECS and the eicosanoid system. In recent years, MAGL has been validated as a potential therapeutic target for several human diseases. Small\u2010molecule MAGL inhibitors have shown considerable promise for the treatment of neurodegenerative diseases, depression, and cancer, with several candidates having advanced to clinical trials. This review briefly outlines the structural features and physiological functions of MAGL, highlights the associations between MAGL and human diseases, and systematically discusses small\u2010molecule MAGL inhibitors developed for different disorders, with the goal of providing a reference for the discovery of more potent MAGL inhibitors.<\/jats:p>","DOI":"10.1002\/med.70089","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T08:24:27Z","timestamp":1784622267000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advances in Small Molecule Research Targeting Monoacylglycerol Lipase in Drug Discovery"],"prefix":"10.1002","author":[{"given":"Shuming","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory Institute of Respiratory Health, Frontiers Science Center for Disease\u2010Related Molecular Network, Precision Medicine Key Laboratory of Sichuan Province &amp; Precision Medicine Center, State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory Institute of Respiratory Health, Frontiers Science Center for Disease\u2010Related Molecular Network, Precision Medicine Key Laboratory of Sichuan Province &amp; Precision Medicine Center, State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weipeng","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery West China Hospital, Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory Institute of Respiratory Health, Frontiers Science Center for Disease\u2010Related Molecular Network, Precision Medicine Key Laboratory of Sichuan Province &amp; Precision Medicine Center, State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory Institute of Respiratory Health, Frontiers Science Center for Disease\u2010Related Molecular Network, Precision Medicine Key Laboratory of Sichuan Province &amp; Precision Medicine Center, State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8618-9200","authenticated-orcid":false,"given":"Jifa","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory Institute of Respiratory Health, Frontiers Science Center for Disease\u2010Related Molecular Network, Precision Medicine Key Laboratory of Sichuan Province &amp; Precision Medicine Center, State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases &amp; Department of Orthodontics West China Hospital of Stomatology, Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6143-5943","authenticated-orcid":false,"given":"Wuyu","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory Institute of Respiratory Health, Frontiers Science Center for Disease\u2010Related Molecular Network, Precision Medicine Key Laboratory of Sichuan Province &amp; Precision Medicine Center, State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"issue":"15","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"7006","DOI":"10.1017\/S0033291723002465","article-title":"The Endocannabinoid System as a Putative Target for the Development of Novel Drugs for the Treatment of Psychiatric Illnesses","volume":"53","author":"Hill M. 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