{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:53:19Z","timestamp":1791269599160,"version":"4.1.0"},"reference-count":153,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004507","name":"Central Drug Research Institute","doi-asserted-by":"publisher","award":["IHP\u20100032"],"award-info":[{"award-number":["IHP\u20100032"]}],"id":[{"id":"10.13039\/501100004507","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004507","name":"Central Drug Research Institute","doi-asserted-by":"publisher","award":["IHP\u20100044"],"award-info":[{"award-number":["IHP\u20100044"]}],"id":[{"id":"10.13039\/501100004507","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medicinal Research Reviews"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cancer remains a major clinical challenge due to persistent therapy resistance, despite significant treatment advances. While chemotherapy often induces initial regression, tumors adapt through complex mechanisms, with autophagy playing a pivotal role. As a conserved cytoplasmic turnover pathway, autophagy protects tumor cells under stress by recycling damaged components and reducing drug toxicity. However, it is also paradoxically capable of triggering autophagic cell death when activated excessively. Importantly, the balance is intricately fine\u2010tuned by short non\u2010coding miRNAs, which orchestrate the regulation of autophagy\u2010related genes (ATGs), thereby influencing cancer cell survival and shaping response to chemotherapy. Although several miRNA\u2010based therapeutics have advanced into preclinical and early clinical testing, most target canonical oncogenic signaling or immune modulation, while the autophagy\u2010specific dimension remains largely unexplored, leaving a translational gap. In this review, we highlight the emerging role of the miRNA\u2010autophagy axis in resistance and propose it as a promising frontier for therapeutic intervention. We further suggest that leveraging miRNA\u2010based autophagy modulation with nanodrugs and conventional therapies could provide a multimodal framework to overcome resistance, reduce toxicity, and advance precision cancer treatment.<\/jats:p>","DOI":"10.1002\/med.70109","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:36:36Z","timestamp":1791268596000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting the MicroRNA\u2010Autophagy Axis: Emerging Advances in Cancer Nanotherapeutics"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6329-6636","authenticated-orcid":false,"given":"Rohit Singh","family":"Rawat","sequence":"first","affiliation":[{"name":"Division of Cancer Biology CSIR\u2010Central Drug Research Institute Lucknow UP India"},{"name":"Jawaharlal Nehru University New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4244-9714","authenticated-orcid":false,"given":"Dibyendu","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Division of Cancer Biology CSIR\u2010Central Drug Research Institute Lucknow UP India"},{"name":"Academy of Scientific &amp; Innovative Research (AcSIR) Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/medsci8010018"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.20517\/cdr.2019.10"},{"key":"e_1_2_12_4_1","doi-asserted-by":"crossref","unstructured":"Y.Tian X.Wang C.Wu J.Qiao H.Jin andH.Li A Protracted War Against Cancer Drug Resistance (2024); 00; 00.","DOI":"10.1186\/s12935-024-03510-2"},{"key":"e_1_2_12_5_1","doi-asserted-by":"crossref","unstructured":"M.Teresa D.Martino P.Tagliaferri andP.Tassone MicroRNA in Cancer Therapy: Breakthroughs and Challenges in Early Clinical Applications (2025) 1\u201314; 00.","DOI":"10.1186\/s13046-025-03391-x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c07345"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-021-00715-9"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radmp.2025.06.002"},{"key":"e_1_2_12_9_1","doi-asserted-by":"crossref","unstructured":"H.Cai F.Zhang F.Xu andC.Yang \u201cMetabolic Reprogramming and Therapeutic Targeting in Non\u2010Small Cell Lung Cancer: Emerging Insights Beyond the Warburg Effect 15 (2025):1564226 https:\/\/doi.org\/10.3389\/fonc.2025.1564226.","DOI":"10.3389\/fonc.2025.1564226"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.115064"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2697"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0092-5"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2023.216307"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.50773"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.9064"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-06677-8"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.101531"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.23323"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2012.07.001"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3858\/emm.2012.44.2.029"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.11.6.19670"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.8.2.18351"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2010.191"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203235"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0994-y"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2016.00134"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.04.009"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/27694127.2024.2305594"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007879"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-020-00551-8"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2016.3259"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-020-0602-4"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5613417"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2611"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.29959"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1586254"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad1047"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12943-015-0480-4\/FIGURES\/7"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431X20198657"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.307405"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41388-019-0986-0"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2022.110566"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2019.11.009"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2019.01.020"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgr184"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.86"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106568"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-019-0287-8"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20160139"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-023-02885-y"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3121492"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5692958"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2019103111"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2011.12.029"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1402604111"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10059-012-0118-y"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.09.133"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2022.166431"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16030657"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25031498"},{"key":"e_1_2_12_61_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4174\/astr.2017.92.2.55","article-title":"A Novel Panel of Serum miR\u201021\/miR\u2010155\/miR\u2010365 as a Potential Diagnostic Biomarker for Breast Cancer","volume":"92","author":"Han J. G.","year":"2017","journal-title":"Annals of Surgical Treatment and Research"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-1407"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23179535"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22116121"},{"key":"e_1_2_12_65_1","doi-asserted-by":"crossref","unstructured":"Y.Jing X.Huang Y.Wang et al. \u201cDiagnostic Value of 5 miRNAs Combined Detection for Breast Cancer \u201dFrontiers in Genetics15 (2024)1482927 https:\/\/doi.org\/10.3389\/fgene.2024.1482927.","DOI":"10.3389\/fgene.2024.1482927"},{"key":"e_1_2_12_66_1","doi-asserted-by":"crossref","unstructured":"R.Li C.Lu W.Yang et al. RESEARCH ARTICLE A Panel of Three Serum microRNA Can Be Used as Potential Diagnostic Biomarkers For Nasopharyngeal Carcinoma (2022):1\u20139 https:\/\/doi.org\/10.1002\/jcla.24194.","DOI":"10.1002\/jcla.24194"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-022-02495-x"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.3635"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-012-0936-9"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916934.2023.2259125"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012873.pub2"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.108.054163"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-23-1698"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnanomed.5c00117"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nwnano.2026.100203"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389450111314070007"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-018-0644-7"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2023.2297817"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2024.112028"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.7324\/JAPS.2026.293265"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1872"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12668-024-01461-6"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.133900"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.22034\/NMRJ.2019.04.002"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1039\/d3nr05656b"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-025-04284-3"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2008.06.001"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.02.005"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.27418"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2018.1517073"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2023.117262"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-023-01050-9"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-020-0802-1"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30621-6"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2015.1040963"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2017.6088"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25031469"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.26534"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2018.08.014"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1545-x"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2020_200106N17"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-022-01168-1"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2024.02.013"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.109997"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.66040"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2021.01.020"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2293-7"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086872"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-024-05174-y"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14215257"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-019-1059-5"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.22286"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026122"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-022-02123-8"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20253010"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.02.006"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2025.217536"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.11.019"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2014.11.023"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.2217\/epi-2016-0035"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2018.0155"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7437281"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15547"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1662"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003697"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2013.00080"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.883262"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06174"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2012.1342"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-82528-2"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2023.41.16_suppl.e13084"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.959630"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1618"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2010.74"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.621409"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-0171"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.22377"},{"key":"e_1_2_12_138_1","first-page":"470","article-title":"INT\u20101B3, An Lnp Formulated miR\u2010193a\u20103p Mimic, Promotes Anti\u2010Tumor Immunity by Enhancing T Cell Mediated Immune Responses via Modulation of the Tumor Microenvironment and Induction of Immunogenic","volume":"15","author":"Duurland C. L.","year":"2024","journal-title":"cell death"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.18632\/ONCOTARGET.27894"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.3389\/fddsv.2023.1181637"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110713"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI63455"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1209026"},{"key":"e_1_2_12_144_1","doi-asserted-by":"crossref","unstructured":"Y. E.Choi K.Meghani M.Brault et al.Konstantinopoulos of microRNA\u2010622 in BRCA1\u2010Mutant Ovarian Cancer 14(2016)429\u2013439 https:\/\/doi.org\/10.1016\/j.celrep.2015.12.046.Platinum.","DOI":"10.1016\/j.celrep.2015.12.046"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2020.102043"},{"key":"e_1_2_12_146_1","doi-asserted-by":"crossref","unstructured":"Y. J.Lee Y. J.Ha Y. N.Kang et al. The Autophagy\u2010Related Marker LC3 Can Predict Prognosis in Human Hepatocellular Carcinoma 8(2013)1\u201310 https:\/\/doi.org\/10.1371\/journal.pone.0081540.","DOI":"10.1371\/journal.pone.0081540"},{"key":"e_1_2_12_147_1","doi-asserted-by":"crossref","unstructured":"H.Zhao M.Yang andJ.Zhao \u201cHigh Expression of LC3B Is Associated With Progression and Poor Outcome in Triple\u2010Negative Breast Cancer \u201dMedical Oncology30 no. 1(2013): 475 https:\/\/doi.org\/10.1007\/s12032-013-0475-1.","DOI":"10.1007\/s12032-013-0475-1"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.15486"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.720849"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.4161\/15548627.2014.981788"},{"key":"e_1_2_12_151_1","doi-asserted-by":"crossref","unstructured":"S.Ladoire F.Penault\u2010llorca L.Senovilla et al. Combined Evaluation of LC3B Puncta and HMGB1 Expression Predicts Residual Risk of Relapse After Adjuvant Chemotherapy in Breast Cancer Combined Evaluation of LC3B Puncta and HMGB1 Expression Predicts Residual Risk of Relapse After Adjuvant Chemotherapy in 8627 (2015) https:\/\/doi.org\/10.1080\/15548627.2015.1082022.","DOI":"10.1080\/15548627.2015.1082022"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2016.1154244"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15507"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1159\/000368848"}],"container-title":["Medicinal Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.70109","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/med.70109","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.70109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:36:42Z","timestamp":1791268602000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/med.70109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,5]]},"references-count":153,"alternative-id":["10.1002\/med.70109"],"URL":"https:\/\/doi.org\/10.1002\/med.70109","archive":["Portico"],"relation":{},"ISSN":["0198-6325","1098-1128"],"issn-type":[{"value":"0198-6325","type":"print"},{"value":"1098-1128","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,5]]},"assertion":[{"value":"2025-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"med.70109"}}