{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T16:43:08Z","timestamp":1792341788020,"version":"4.4.0"},"reference-count":156,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2025\u201000520021"],"award-info":[{"award-number":["2025\u201000520021"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102026\u201025522411"],"award-info":[{"award-number":["RS\u20102026\u201025522411"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medicinal Research Reviews"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Targeted elimination of pathogenic proteins remains a fundamental challenge in therapeutic intervention, particularly for proteins considered \u201cundruggable\u201d by conventional inhibition\u2010based approaches. Aptamer\u2013based targeted protein degradation (TPD) has emerged as a versatile strategy that leverages the high specificity, structural programmability, and chemical tunability of nucleic acid aptamers to redirect disease\u2010relevant proteins toward endogenous degradation pathways. Intracellular platforms, exemplified by aptamer\u2010conjugated proteolysis\u2010targeting chimeras (PROTACs), induce ubiquitination and proteasomal degradation of cytosolic and nuclear targets. In parallel, extracellular and membrane\u2010targeting modalities, including aptamer\u2010conjugated lysosome\u2010targeting chimeras (LYTACs) and related lysosomal degradation systems, enable clearance of secreted and membrane\u2010bound proteins that are inaccessible to proteasome\u2010based strategies. Collectively, these approaches broaden the potentially degradable proteome and offer opportunities to improve target selectivity and therapeutic safety. However, most aptamer\u2010based TPD systems remain at the proof\u2010of\u2010concept or early preclinical stage, with limited standardization of degradation potency, kinetics, selectivity, and in vivo efficacy. Additional challenges include the discovery of functionally active aptamers, preservation of affinity and activity after chemical modification or conjugation, efficient delivery, chemical stability, controlled biodistribution, and mitigation of innate immune activation. This review provides a mechanistic and comparative framework for intracellular and extracellular aptamer\u2010based TPD strategies, with emphasis on quantitative performance, delivery considerations, technical bottlenecks, and their translational potential for precision protein\u2010targeted therapeutics.<\/jats:p>","DOI":"10.1002\/med.70110","type":"journal-article","created":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T16:20:32Z","timestamp":1792340432000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aptamer\u2013Based Targeted Protein Degradation: Mechanistic Principles, Delivery Strategies, and Translational Opportunities"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9173-2667","authenticated-orcid":false,"given":"Ambrin","family":"Malik","sequence":"first","affiliation":[{"name":"Public Health Laboratories Division National Institutes of Health Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyeon","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Biological Engineering, College of Engineering Konkuk University Seoul Republic of Korea"},{"name":"Advanced Materials Program, Department of Biological Engineering Konkuk University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaesung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biological Engineering, College of Engineering Konkuk University Seoul Republic of Korea"},{"name":"Advanced Materials Program, Department of Biological Engineering Konkuk University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0545-0970","authenticated-orcid":false,"given":"Ki Soo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biological Engineering, College of Engineering Konkuk University Seoul Republic of Korea"},{"name":"Advanced Materials Program, Department of Biological Engineering Konkuk University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,18]]},"reference":[{"key":"e_1_2_13_2_1","first-page":"301","volume-title":"Annual Reports in Medicinal Chemistry","author":"Mainolfi N.","year":"2017"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.2020"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-02004-x"},{"key":"e_1_2_13_5_1","volume-title":"Targeted Protein Degradation as a Therapeutic Avenue for Alzheimer's Disease","author":"Mondal T.","year":"2022"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2024.104178"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2025.137411"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.135911"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03813-0"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.4c00536"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c10379"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25136833"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/s150716281"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaf219"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02556-3"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp4099667"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.3c01454"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1997.1281"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/bab.2244"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.704077"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00273-x"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac1210"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines5030049"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c17041"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2010.66"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-57823-5"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.31635\/ccschem.025.202506075"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2022.102310"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2022.867419"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11010060"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0148-1"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11050851"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2018.00128"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21072576"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9051131"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13206-026-00257-y"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00371-6"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-024-00729-9"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2021.02.024"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28520-4"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.2c00310"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c01557"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202102170"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c04794"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202306760"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202425123"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202308924"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13206-025-00233-y"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1722-1"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.09.009"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.141230798"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.07.114"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13206-026-00258-x"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1039\/d2cs00193d"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202107347"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.3c00126"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.5c00242"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2023.117299"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1191"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.4c06177"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.99588"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202401623"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c02619"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2022.09.008"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202503958"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1092901"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32050-4"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01983-1"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12010187"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3SC04249A"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2022.02.006"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2026.119299"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1195372"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2024.101852"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.1048148"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2545-9"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202218106"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13206-025-00238-7"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.98467"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2024.116055"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c03556"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacsau.4c00260"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2424500122"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1089\/nat.2017.0683"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1089\/nat.2016.0627"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25010003"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2020.06.015"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.17.75"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2020.03.009"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-46974-4"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113690"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S23747"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-019-0369-8"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2016.1156266"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1731"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrp.2025.102866"},{"key":"e_1_2_13_97_1","doi-asserted-by":"crossref","unstructured":"M.Song J.Zhou A.Herrera P.Baines andJ. J.Rossi Inhalation Delivered RNA Aptamer for Therapeutics Against SARS\u2010CoV2 \u201d bioRxiv October 30 2023 https:\/\/doi.org\/10.1101\/2023.10.28.564096.","DOI":"10.1101\/2023.10.28.564096"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.4c00563"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.66669"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-004-7676-4"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13206-026-00274-x"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.6422"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15020411"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010716-104558"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1091809"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1089\/nat.2017.0680"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21239123"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2022.05.02"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.08.004"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.08.005"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.34133\/research.0126"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c05750"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.3934\/bioeng.2025024"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2023.05.008"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986711797189565"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22073605"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.4c02466"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.5c00003"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacsau.5c00978"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c05456"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.8b00692"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c00953"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1858"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.118019"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1039\/d2cs00200k"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1536569"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.199"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12195-020-00651-y"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2025.101369"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.15212\/AMM-2024-0065"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2016.1126244"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20243018"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70401"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1039\/D6CB00062B"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00482"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2747"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867325666181008142831"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986711797189547"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph17040494"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115793"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.1177\/1087057114562544"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2011.05.015"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2020.07.013"},{"key":"e_1_2_13_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dmpk.2018.10.003"},{"key":"e_1_2_13_145_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12070646"},{"key":"e_1_2_13_146_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CS00339B"},{"key":"e_1_2_13_147_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202500184"},{"key":"e_1_2_13_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2025.101314"},{"key":"e_1_2_13_149_1","doi-asserted-by":"publisher","DOI":"10.1089\/nat.2014.0529"},{"key":"e_1_2_13_150_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1cs00762a"},{"key":"e_1_2_13_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2024.155627"},{"key":"e_1_2_13_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17997-6"},{"key":"e_1_2_13_153_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomedchemau.5c00111"},{"key":"e_1_2_13_154_1","doi-asserted-by":"publisher","DOI":"10.1093\/abt\/tbab027"},{"key":"e_1_2_13_155_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12020473"},{"key":"e_1_2_13_156_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c04457"},{"key":"e_1_2_13_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2024.102408"}],"container-title":["Medicinal Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.70110","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/med.70110","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.70110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T16:20:39Z","timestamp":1792340439000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/med.70110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,18]]},"references-count":156,"alternative-id":["10.1002\/med.70110"],"URL":"https:\/\/doi.org\/10.1002\/med.70110","archive":["Portico"],"relation":{},"ISSN":["0198-6325","1098-1128"],"issn-type":[{"value":"0198-6325","type":"print"},{"value":"1098-1128","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,18]]},"assertion":[{"value":"2026-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"med.70110"}}