{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T23:34:23Z","timestamp":1785281663511,"version":"3.55.0"},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T00:00:00Z","timestamp":1574121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003176","name":"Ministerio de Educaci\u00f3n, Cultura y Deporte","doi-asserted-by":"publisher","award":["FPU13\/04211"],"award-info":[{"award-number":["FPU13\/04211"]}],"id":[{"id":"10.13039\/501100003176","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp; Gen Med"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Monoamine oxidase (MAO) activity has been traditionally implicated in blood pressure through its effects on biogenic amine levels such as catecholamines, serotonin, and dopamine. Nowadays, this role is considered relegated to side\u2010effects such as orthostatic hypotension and\/or hypertensive crisis derived from MAO\u2010inhibitory treatments in patients with psychiatric disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the present work we have found an association between a polymorphic variant of <jats:italic>MAOB<\/jats:italic> gene and arterial hypertension in obese hypogonadic patients. The study cases comprised a series of 219 nondiabetic males with a body mass index \u226530\u00a0kg\/m<jats:sup>2<\/jats:sup> and aged &lt;45\u00a0years. Hypogonadism was defined as subnormal testosterone concentrations, when free testosterone values ranged &lt;65\u00a0pg\/ml.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>MAOB<\/jats:italic> rs3027452\u2010A allele carriers were significantly over\u2010represented among hypertensive (HT) patients (25.49%) in comparison to either the non\u2010HT patients (10%, OR\u00a0=\u00a03.079 CI<jats:sub>95<\/jats:sub> [1.364\u20136.952], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.005, Chi\u2010square test) and the control population series of nonobese nor hypogonadic males (also 10%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.003 Chi\u2010square test). Upon adjusted, an independent association was shown with the hypogonadic group with hypertension when compared with nonhypertensive hypogonadics (Beta\u00a0=\u00a03.653, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.005). When quantitative analysis was performed, hypertensive patients harboring rs3027452\u2010A allele showed higher systolic blood pressure values (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.038, Mann\u2013Whitney U\u2010test) as well as an increased Systolic\u2010Diastolic range despite following HT treatment (\u2206mmHg 54 vs. 48 for rs3027452\u2010A and rs3027452\u2010G respectively, <jats:italic>p<\/jats:italic>\u2010value .019, Mann\u2013Whitney U\u2010test). Previous studies on <jats:italic>MAOB<\/jats:italic> revealed that rs3027452\u2010A allele has been correlated to a lower activity of the enzyme, what gives a functional evidence over our observation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>If this result could be extrapolated to other hypertensive patient groups, it would implicate a review of the markers and therapeutic targets on human hypertension.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.1040","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T19:24:03Z","timestamp":1574191443000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Monoamino oxidase alleles correlate with the presence of essential hypertension among hypogonadic patients"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2024-4363","authenticated-orcid":false,"given":"Jos\u00e9 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Molina\u2010Vega","sequence":"additional","affiliation":[{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Endocrinolog\u00eda y Nutrici\u00f3n del Hospital Virgen de la Victoria Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA) Universidad de M\u00e1laga M\u00e1laga Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y la Nutrici\u00f3n, CIBERobn M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Cardona","sequence":"additional","affiliation":[{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Endocrinolog\u00eda y Nutrici\u00f3n del Hospital Virgen de la Victoria Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA) Universidad de M\u00e1laga M\u00e1laga Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y la Nutrici\u00f3n, CIBERobn M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Tinahones","sequence":"additional","affiliation":[{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Endocrinolog\u00eda y Nutrici\u00f3n del Hospital Virgen de la Victoria Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA) Universidad de M\u00e1laga M\u00e1laga Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y la Nutrici\u00f3n, CIBERobn M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 C.","family":"Fern\u00e1ndez\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Endocrinolog\u00eda y Nutrici\u00f3n del Hospital Virgen de la Victoria Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA) Universidad de M\u00e1laga M\u00e1laga Spain"},{"name":"Centro de 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