{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:02:10Z","timestamp":1753869730365,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602768","81773336","81803146"],"award-info":[{"award-number":["81602768","81773336","81803146"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp;amp; Gen Med"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Psoriasis is a chronic inflammatory disorder of the skin, and genetic factors are reported to be involved in the disease pathogenesis. Many studies have named psoriasis candidate genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>In this study, we determined the mutation frequency of 7 variable genes in 1,027 psoriatic patients and investigated its possible mechanism associated with psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A total of 7 variable genes from 1,027 psoriatic patients were amplified and sequenced using the Sanger method. The mutation frequency was compared to that of non\u2010psoriatic individuals in Asia using information from databases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 7 investigated genes, the mutation frequency of <jats:italic>ACOT12<\/jats:italic> (c.80A&gt;G, 9.98% vs. 5.85%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) and CT62 (c.476C&gt;T,15.8% vs. 9.93%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) was found to be significantly higher than among non\u2010psoriatic Asian individuals. The mutation frequencies of <jats:italic>CASZ1<\/jats:italic>(c.599T&gt;G),<jats:italic> SPRED1<\/jats:italic>(c.155A&gt;G), and <jats:italic>ACOT12<\/jats:italic> (c.80A&gt;G) differed significantly between the groups organized by medical history, PASI, and family history. <jats:italic>SPRED1<\/jats:italic> gene variants (17.25% vs. 7.78%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01) showed a stronger association with the family history group at the onset of psoriasis than with the no family history group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results provide a comprehensive correlation analysis of susceptibility genes in psoriasis patients. Clinical characteristics of patients play important roles in the development of psoriatic skin.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.1098","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T09:14:22Z","timestamp":1576833262000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Variation at ACOT12 and CT62 locus represents susceptibility to psoriasis in Han population"],"prefix":"10.1002","volume":"8","author":[{"given":"Jianxiao","family":"Xing","sequence":"first","affiliation":[{"name":"Shanxi Key Laboratory of Stem Cells for Immunological Dermatosis Institute of Dermatology Taiyuan Central Hospital of Shanxi Medical University Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xincheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shanxi Key Laboratory of Stem Cells for Immunological Dermatosis Institute of Dermatology 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