{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:02:10Z","timestamp":1753869730760,"version":"3.41.2"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,25]],"date-time":"2020-03-25T00:00:00Z","timestamp":1585094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp;amp; Gen Med"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Plasma concentrations of antiretrovirals (ARVs) regimens have considerably varied in individuals of human immunodeficiency virus (HIV) because of variations in the expression of drug\u2010metabolizing and transporter genes.\u00a0Transporter genes play an important role in the disposition of drugs.\u00a0Polymorphism in\u00a0transporter gene (<jats:italic>ABCC3)\u00a0<\/jats:italic>affects the <jats:italic>MRP3<\/jats:italic> expression and varies the treatment outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We examined the polymorphism of\u00a0<jats:italic>ABCC3<\/jats:italic>\u20101767G\/A gene in a total of 165 HIV patients (out of 165 HIV patients, 34 were with and 131 were without hepatotoxicity) and 156 healthy individuals using the polymerase chain reaction\u2013restriction fragment length polymorphism method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In univariate analysis, we found a decreased prevalence of<jats:italic>\u00a0ABCC3<\/jats:italic>\u00a01767GA, 1767GA+AA\u00a0genotypes, and 1767A allele in patients with\u00a0hepatotoxicity as compared to patients without hepatotoxicity (23.5% vs.\u00a028.2% and\u00a023.5% vs. 30.53%; 11.76% vs. 16.41%),\u00a0while a higher prevalence of\u00a01767AA genotype was observed in\u00a0HIV patients in comparison with healthy controls (2.3% vs. 1.3%, odds ratio [OR]\u00a0=\u00a01.71, 95% confidence interval [CI]: 0.23\u201315.03, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.89). The frequency of<jats:italic>\u00a0ABCC3<\/jats:italic>\u20101767AA genotype was dispersed higher in individuals with early and advanced HIV disease stage in comparison with healthy controls (5.3% vs.\u00a01.3%, OR\u00a0=\u00a04.73, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.70; 8.9% vs. 1.3%, OR\u00a0=\u00a01.89, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.91). A higher occurrence of\u00a0<jats:italic>ABCC3\u2010<\/jats:italic>1767AA genotype was found in tobacco using\u00a0HIV patients without hepatotoxicity compared with nonusers (4.7% vs.\u00a01.1%, OR\u00a0=\u00a04.28, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.52).\u00a0The distribution of\u00a0<jats:italic>ABCC3<\/jats:italic>\u20101767GA genotype was higher in nevirapine receiving HIV patients irrespective of their hepatotoxicity status as compared to nonusers (30.4% vs.\u00a09.1%, OR\u00a0=\u00a03.34, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.22;\u00a029.4% vs. 16.7%, OR\u00a0=\u00a01.69, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.77). In multivariate analysis, HIV\u00a0patients receiving nevirapine and with hepatotoxicity was found to have a significant risk for severity of hepatotoxicity (OR\u00a0=\u00a04.56, 95% CI: 1.60\u201312.99, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>ABCC3<\/jats:italic>\u00a01767G\/A polymorphism was not significantly associated with susceptibility to ARV\u2010associated hepatotoxicity, although\u00a0<jats:italic>ABCC3<\/jats:italic>\u00a01767AA genotype designated a risk for acquisition of hepatotoxicity and advancement of the disease. Nevirapine usage emerged as an independent risk factor for hepatotoxicity severity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.1124","type":"journal-article","created":{"date-parts":[[2020,3,25]],"date-time":"2020-03-25T10:40:17Z","timestamp":1585132817000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prevalence of <i>ABCC3<\/i>\u20101767G\/A polymorphism among patients with antiretroviral\u2010associated hepatotoxicity"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7251-3097","authenticated-orcid":false,"given":"HariOm","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Molecular Biology National AIDS Research Institute Pune India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonam","family":"Lata","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology National AIDS Research Institute Pune India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7474-5983","authenticated-orcid":false,"given":"Ranjana","family":"Choudhari","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology National Institute of Occupational Health Ahmedabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tapan N.","family":"Dhole","sequence":"additional","affiliation":[{"name":"Department of Microbiology Sanjay Gandhi Post Graduate Institute of Medical Sciences Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(02)02211-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.16.1295"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.24.17.1732.52347"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2006.04.009"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.05.061"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4236\/jct.2010.13019"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12654"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113025"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.043547"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425250902976854"},{"key":"e_1_2_9_12_1","first-page":"3537","article-title":"Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance\u2010associated protein gene (MRP1), in human cancer cell lines","volume":"57","author":"Kool M.","year":"1997","journal-title":"Cancer Research"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.110.003533"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.23.223"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2165\/11592660-000000000-00000"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5359.99597"},{"key":"e_1_2_9_17_1","unstructured":"Reisler R. 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