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Further, costs related to treatment often constitute a substantial financial burden for patients and health systems. While its epidemiology is still unclear, newborn screenings suggest that its actual prevalence rate is significantly higher than previously suspected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Based on well\u2010established methodologies, this study gives an overview about the background of the development of FD\u2010related research and provides a critical view of future needs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On the grounds of benchmarking findings, an increasing research activity on FD can be observed. Most publishing countries are the USA, some European countries, Japan, Taiwan, and South Korea. In general, high\u2010income countries publish comparably more on FD than low\u2010 or middle\u2010income economies. The countries' financial and infrastructural background are unveiled as crucial factors for the FD research activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, there is a need to foster FD research infrastructure in developing and emerging countries with focus on cost\u2010intensive genetic research that is independent from economic interests of big pharmaceutical companies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.1163","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T13:24:26Z","timestamp":1581081866000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Global research on Fabry's disease: Demands for a rare disease"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0716-9872","authenticated-orcid":false,"given":"Doris","family":"Klingelh\u00f6fer","sequence":"first","affiliation":[{"name":"Institute of Occupational, Social and Environmental Medicine Goethe University Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Braun","sequence":"additional","affiliation":[{"name":"Institute of Occupational, Social and Environmental Medicine Goethe University Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebekka K.","family":"Seeger\u2010Zybok","sequence":"additional","affiliation":[{"name":"Institute of Occupational, Social and Environmental Medicine Goethe University Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Quarcoo","sequence":"additional","affiliation":[{"name":"Institute of Occupational, Social and Environmental Medicine Goethe University Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00f6rthe","family":"Br\u00fcggmann","sequence":"additional","affiliation":[{"name":"Institute of Occupational, Social and Environmental Medicine Goethe University Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Groneberg","sequence":"additional","affiliation":[{"name":"Institute of Occupational, Social and Environmental Medicine Goethe University Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1898.tb16317.x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-2-200701160-00148"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2016.122"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/Jci114027"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-015-0253-6"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.11.3903"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/Nejm196705252762101"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12937-018-0313-6"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.5582\/bst.2015.01048"},{"key":"e_1_2_12_11_1","volume-title":"CIA, the world factbook, 2017","author":"CIA","year":"2017"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h210"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-4-200302180-00014"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.gim.0000237866.70357.c6"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/Nejm200107053450102"},{"key":"e_1_2_12_16_1","volume-title":"Regulation (EC) No 141\/2000 of the European Parliament and of the Council of 16 December 1999 on orphan medicinal products","author":"EU","year":"1999"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1012443001449"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01986897"},{"key":"e_1_2_12_19_1","series-title":"Biotechnology in agriculture industry and medicine","first-page":"107","volume-title":"Strategic alliances in biotechnology and pharmaceuticals","author":"Floether F. 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