{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:02:27Z","timestamp":1753869747348,"version":"3.41.2"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T00:00:00Z","timestamp":1583366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp;amp; Gen Med"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to investigate the effects of P450 oxidoreductase (<jats:italic>POR<\/jats:italic>) genetic polymorphisms on the pharmacokinetic parameters of amlodipine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>After a single 10\u2010mg dose of amlodipine administration, 25 healthy male subjects completed genotyping for 12 single nucleotide polymorphisms (SNPs) of the <jats:italic>POR<\/jats:italic> genes, cytochrome P450 (CYP)3A4 g.25343G&gt;A (CYP3A4*1G), and CYP3A5 g.12083G&gt;A (CYP3A5*3). Stratified analysis and in silico analysis to predict the possible effects of given variants on splicing were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The maximum blood concentration (C<jats:sub>max<\/jats:sub>) of amlodipine in carriers of g.57332T&gt;C and g.56551G&gt;A SNPs of the <jats:italic>POR<\/jats:italic> gene was statistically significantly different. In addition, T\u2010allele carriers of g.57332T&gt;C had a 21% higher C<jats:sub>max<\/jats:sub> than those with the CC genotype (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.007). Subjects who carried the wild\u2010type g.56551G&gt;A allele also had a 1.12\u2010fold significantly higher C<jats:sub>max<\/jats:sub> than subjects with mutant\u2010type homozygous carriers (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.033). In stratified analyses, g.57332T&gt;C was significantly associated with a 1.3\u2010fold increase in C<jats:sub>max<\/jats:sub> value in T\u2010allele carriers compared with subjects with the CC genotype in <jats:italic>CYP3A4<\/jats:italic> and <jats:italic>CYP3A5<\/jats:italic> expressers. POR g.57332T&gt;C increased the score above the threshold in both ESEfinder 3.0 and HSF 3.1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study identified a novel SNP of the <jats:italic>POR<\/jats:italic> gene, which affected amlodipine metabolism and may reduce interindividual variation in responses to amlodipine.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.1201","type":"journal-article","created":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T13:41:20Z","timestamp":1583415680000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of cytochrome P450 oxidoreductase genotypes on the pharmacokinetics of amlodipine in healthy Korean subjects"],"prefix":"10.1002","volume":"8","author":[{"given":"Ji Min","family":"Han","sequence":"first","affiliation":[{"name":"College of Pharmacy and Graduate School of Pharmaceutical Sciences Ewha Womans University Seoul Republic of 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