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Phenotypically, besides intrauterine growth restriction (IUGR) and brain as well as heart abnormalities, hypospadias, and lung dysplasia were observed. Potential genetic causes for specific phenotypes in these cases were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study defined the molecular bases for the patients of CdCS, which is important for genetic counseling for these families. The findings of present study expand the clinical features of CdCS in the fetal period, and provided important information for further refining the genotypic\u2013phenotypic correlations for this syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.1312","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T03:46:30Z","timestamp":1591328790000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Clinical and molecular characterization of 12 prenatal cases of Cri\u2010du\u2010chat syndrome"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0602-6063","authenticated-orcid":false,"given":"Ying","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Medical Genetics Hunan Provincial Maternal and Child Health Care Hospital Changsha Hunan China"},{"name":"National Health Commission Key Laboratory of Birth Defects Research, Prevention and 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