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The two haplotypes encoding <jats:italic>APOE<\/jats:italic>\u2010E4 showed strong associations with AD that did not differ between intermediate and high likelihood AD. In contrast, a <jats:italic>TOMM40<\/jats:italic> haplotype encoding <jats:italic>APOE\u2010<\/jats:italic>E3 was identified as risk haplotype of high\u2010 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0186), but not intermediate likelihood AD (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.7530). Furthermore, the variant allele of rs2075650 located in intron 2 of <jats:italic>TOMM40<\/jats:italic>, increased the risk of high\u2010, but not intermediate likelihood AD on the <jats:italic>APOE<\/jats:italic>\u2010\u03b53\/\u03b53 background (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0230).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The striking association of <jats:italic>TOMM40<\/jats:italic> only with high likelihood AD may explain some contrasting results for <jats:italic>TOMM40<\/jats:italic> in clinical studies and may reflect an association with more advanced disease and\/or suggest a role of <jats:italic>TOMM40<\/jats:italic> in the pathogenesis of neurofibrillary tangles.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.1317","type":"journal-article","created":{"date-parts":[[2020,5,30]],"date-time":"2020-05-30T09:42:30Z","timestamp":1590831750000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A <i>TOMM40\/APOE<\/i> allele encoding <i>APOE<\/i>\u2010E3 predicts high likelihood of late\u2010onset Alzheimer\u2019s disease in autopsy cases"],"prefix":"10.1002","volume":"8","author":[{"given":"Selma M.","family":"Soyal","sequence":"first","affiliation":[{"name":"Institute of Pharmacology and Toxicology Paracelsus Medical University Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Kwik","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology Paracelsus Medical University Salzburg 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