{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:28:45Z","timestamp":1787956125305,"version":"build-2784847793"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T00:00:00Z","timestamp":1592870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005925","name":"Buddhist Tzu Chi Medical Foundation","doi-asserted-by":"publisher","award":["TCMF\u2010EP108\u201005"],"award-info":[{"award-number":["TCMF\u2010EP108\u201005"]}],"id":[{"id":"10.13039\/501100005925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["MOST108\u20102314\u2010B\u2010303\u2010026\u2010MY3"],"award-info":[{"award-number":["MOST108\u20102314\u2010B\u2010303\u2010026\u2010MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008108","name":"Taipei Tzu Chi Hospital","doi-asserted-by":"publisher","award":["TCRD\u2010TPE\u2010106\u2010C1\u20101"],"award-info":[{"award-number":["TCRD\u2010TPE\u2010106\u2010C1\u20101"]}],"id":[{"id":"10.13039\/501100008108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008108","name":"Taipei Tzu Chi Hospital","doi-asserted-by":"publisher","award":["TCRD\u2010TPE\u2010106\u2010RT\u20103"],"award-info":[{"award-number":["TCRD\u2010TPE\u2010106\u2010RT\u20103"]}],"id":[{"id":"10.13039\/501100008108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp;amp; Gen Med"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Galectin\u20103 plays a crucial role in the regulation of inflammation. The aim of this study was to elucidate the association between <jats:italic>LGALS3<\/jats:italic> genotypes, galectin\u20103 levels, and inflammatory marker levels in patients with coronary artery disease (CAD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 474 patients with CAD were enrolled. Significant correlations were discerned between galectin\u20103 levels and leukocyte counts, C\u2010reactive protein, soluble intercellular adhesion molecule\u20101, and matrix metalloproteinase 9 levels (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). The <jats:italic>LGALS3<\/jats:italic> rs2274273, rs4644, rs4652 genotypes, and haplotypes CAC, CCC, and ACT exhibited a significant association with galectin\u20103 levels (for genotypes, <jats:italic>p<\/jats:italic>\u00a0=\u00a01.05\u00a0\u00d7\u00a010<jats:sup>\u221225<\/jats:sup>, 3.54\u00a0\u00d7\u00a010<jats:sup>\u221225<\/jats:sup>, and 2.74\u00a0\u00d7\u00a010<jats:sup>\u22127<\/jats:sup>, respectively). Multivariate analysis showed <jats:italic>LGALS3<\/jats:italic> rs2274273 and rs4644 genotypes contributing to 20.8% variation of galectin\u20103 levels. However, there was no association between <jats:italic>LGALS3<\/jats:italic> genotypes and other inflammatory marker levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data showed strong genetic determinants of galectin\u20103 levels in patients with CAD. The galectin\u20103 levels, but not <jats:italic>LGALS3<\/jats:italic> genotypes, were associated with multiple inflammatory marker levels. Further study may be necessary to elucidate the molecular mechanism of galectin\u20103 in the pathogenesis of chronic inflammatory disorders.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.1370","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T12:40:38Z","timestamp":1592916038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Genetic determinants of circulating galectin\u20103 levels in patients with coronary artery disease"],"prefix":"10.1002","volume":"8","author":[{"given":"Yu\u2010Huang","family":"Liao","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Internal Medicine Taipei Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation New Taipei city Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Sheng","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Research Taipei Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation New Taipei city Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyh\u2010Ming J.","family":"Juang","sequence":"additional","affiliation":[{"name":"Cardiovascular Center and Division of Cardiology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan"},{"name":"National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu\u2010Tien","family":"Chiang","sequence":"additional","affiliation":[{"name":"Cardiovascular Center and Division of Cardiology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan"},{"name":"National Taiwan University College of Medicine Taipei Taiwan"},{"name":"Cardiovascular Center and Division of Cardiology Fu\u2010Jen Catholic University Hospital New Taipei city Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leay\u2010Kiaw","family":"Er","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Internal Medicine Taipei Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation New Taipei city Taiwan"},{"name":"School of Medicine Tzu Chi University Hualien Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semon","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Life Science Chinese Culture University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8218-6827","authenticated-orcid":false,"given":"Yu\u2010Lin","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Research Taipei Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation New Taipei city Taiwan"},{"name":"School of Medicine Tzu Chi University Hualien Taiwan"},{"name":"Cardiovascular Center and Division of Cardiology Department of Internal Medicine Taipei Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation New Taipei city Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jim\u20102015\u2010000041"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.09.014"},{"issue":"4","key":"e_1_2_11_4_1","first-page":"983","article-title":"Galectin\u20103 and cancer (Review)","volume":"25","author":"Califice S.","year":"2004","journal-title":"International Journal of Oncology"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201012\u20102940"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2012.02.065"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102567.1998.00517.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010\u2010015\u20102367\u20105"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2010.538080"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102796.2011.02476.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047385"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2008.11.009"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.21996"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2013.00037"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010065X.2009.00794.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9398401"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067\u2010011\u20101741\u20102"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3760\/cmaj.issn.0366-6999.20130217"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025103"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5830361"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwt006"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2009.10.036"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304964"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2016.19"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.148510"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162297"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201007\u20103233"},{"key":"e_1_2_11_28_1","unstructured":"National Center for Biotechnology Information.dbSNP. HapMap\u2010HCB. Retrieved fromhttps:\/\/www.ncbi.nlm.nih.gov\/snp\/rs4644;https:\/\/www.ncbi.nlm.nih.gov\/snp\/rs4652;https:\/\/www.ncbi.nlm.nih.gov\/snp\/rs2274273"},{"key":"e_1_2_11_29_1","unstructured":"National Center for Biotechnology Information.dbSNP. HapMap\u2010CEU. Retrieved fromhttps:\/\/www.ncbi.nlm.nih.gov\/snp\/rs4644;https:\/\/www.ncbi.nlm.nih.gov\/snp\/rs4652;https:\/\/www.ncbi.nlm.nih.gov\/snp\/rs2274273"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00251a020"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304\u20104165(97)00086\u2010X"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e04\u201012\u20101119"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867322666150520095008"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487314552797"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083481"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.05.001"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.10.012"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.01.014"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3858\/emm.2012.44.6.044"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009\u20101619"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12605"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13402\u2010012\u20100075\u20107"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2010.099"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2012.150"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2014.06.008"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2017.11.026"}],"container-title":["Molecular Genetics &amp; Genomic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmgg3.1370","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mgg3.1370","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mgg3.1370","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mgg3.1370","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T10:57:04Z","timestamp":1708513024000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mgg3.1370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,23]]},"references-count":45,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1002\/mgg3.1370"],"URL":"https:\/\/doi.org\/10.1002\/mgg3.1370","archive":["Portico"],"relation":{},"ISSN":["2324-9269","2324-9269"],"issn-type":[{"value":"2324-9269","type":"print"},{"value":"2324-9269","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,23]]},"assertion":[{"value":"2020-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1370"}}