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The study aimed to assess the association between <jats:italic>MIF<\/jats:italic> polymorphisms (\u2212794 CATT<jats:sub>5\u20108<\/jats:sub> and \u2212173 G&gt;C), MIF <jats:italic>in situ<\/jats:italic> expression, and MIF serum concentrations with susceptibility and disease activity in patients with non\u2010segmental vitiligo (NSV) from western Mexico.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 111 patients with NSV and 201 control subjects. Genotyping was performed by conventional PCR (\u2212794 CATT<jats:sub>5\u20108<\/jats:sub>) and PCR\u2010RFLP (\u2212173 G&gt;C) methods. <jats:italic>MIF<\/jats:italic> mRNA expression was quantified by real\u2010time PCR and MIF serum concentrations were determined by ELISA kit. Histopathological samples were analyzed by automated immunohistochemistry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:italic>MIF<\/jats:italic> polymorphisms were associated with NSV susceptibility. Serum concentrations of MIF were higher in patients with active NSV and correlated negatively with the years of evolution. The depigmented skin from patients with active vitiligo showed a high expression of MIF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>MIF<\/jats:italic> polymorphisms increase the risk of NSV in the western Mexican population. The serum concentrations of MIF and <jats:italic>in situ<\/jats:italic> expression are associated with active NSV.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.1416","type":"journal-article","created":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T05:22:30Z","timestamp":1595568150000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Macrophage inhibitory factor (MIF) gene polymorphisms are associated with disease susceptibility and with circulating MIF levels in active non\u2010segmental vitiligo in patients from western Mexico"],"prefix":"10.1002","volume":"8","author":[{"given":"Alejandra","family":"Garcia\u2010Orozco","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n en Inmunolog\u00eda y Dermatolog\u00eda\/Instituto Dermatol\u00f3gico de Jalisco \u201cDr. Jos\u00e9 Barba Rubio\u201d Centro Universitario de Ciencias de la Salud Universidad de Guadalajara Zapopan 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