{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T12:56:29Z","timestamp":1770296189989,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T00:00:00Z","timestamp":1595894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC\u20108182207"],"award-info":[{"award-number":["NSFC\u20108182207"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp;amp; Gen Med"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Psoriasis is a chronic inflammatory dermatosis with complex genetic basis supported by family investigation. Renal involvement in psoriasis is sparsely studied and its pathogenesis is still unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>We describe the case of a 7\u2010year\u2010old boy presented new onset of nephropathy two weeks after a flare\u2010up of psoriasis. His mother had a long history of psoriasis without abnormal urinalysis records. The case showed non\u2010nephrotic range proteinuria, microscopic hematuria without any other abnormal results including renal function, complement cascade, and ultrasound. Renal pathological demonstrated the diagnosis of C3 glomerulonephritis (C3GN) showing mesangial proliferative glomerulonephritis with C3 staining only, effacement of podocyte process and intramembranous electron dense deposit by electric microscopy. Parent\u2010child trio WES performed to screening the common variants of psoriasis susceptibility locus and also the rare variants associated with C3GN. We identified a missense single nucleotide polymorphism of <jats:italic>CARD14<\/jats:italic> (*607211, rs34367357, p.Val585Ile) carried by the proband and his mother. Meta\u2010analysis proved the association of rs34367357 and psoriasis (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.006, OR\u00a0=\u00a01.23). A hemizygouse mutation of <jats:italic>CLCN5<\/jats:italic> (*300008, c.1904A\uff1eG,p.Asn635Ser) was identified for diagnosis of Dent disease (*300009).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The case highlights the genetic study is necessary to facilitate disease differentiation in new onset of nephropathy with psoriasis in children.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.1430","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T06:38:41Z","timestamp":1596004721000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Genetic and pathological findings in a boy with psoriasis and C3 glomerulonephritis: A case report and literature review"],"prefix":"10.1002","volume":"8","author":[{"given":"Lei","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Nephrology and Rheumatology Children's Hospital of Zhengzhou University Henan Children\u2019s Hospital Zhengzhou Children\u2019s Hospital Zhengzhou Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Children's Hospital of Fudan University National Pediatric Medical Center of China Shanghai China"},{"name":"Shanghai Kidney Development and Pediatric Kidney Disease Research Center Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanghai","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology Children's Hospital of Zhengzhou University Henan Children\u2019s Hospital Zhengzhou Children\u2019s Hospital Zhengzhou Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shufeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology Children's Hospital of Zhengzhou University Henan Children\u2019s Hospital Zhengzhou Children\u2019s Hospital Zhengzhou Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology Children's Hospital of Zhengzhou University Henan Children\u2019s Hospital Zhengzhou Children\u2019s Hospital Zhengzhou Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Nephrology Children's Hospital of Fudan University National Pediatric Medical Center of China Shanghai China"},{"name":"Shanghai Kidney Development and Pediatric Kidney Disease Research Center Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nephrology Children's Hospital of Fudan University National Pediatric Medical Center of China Shanghai 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