{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:01:35Z","timestamp":1753869695544,"version":"3.41.2"},"reference-count":49,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T00:00:00Z","timestamp":1608336000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp;amp; Gen Med"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>TH17\/IL\u201023 immune axis is considered to be involved in the pathogenesis of autoimmune and chronic inflammatory diseases. Bullous pemphigoid (BP) is the most frequent autoimmune blistering disease, characterized by the presence of autoantibodies against the components of the dermal\u2010epidermal junction. Animal studies and characterization of patient samples point toward a contribution of TH17 cells in BP pathogenesis. However, genetic polymorphisms in the genes of TH17\/IL\u201023 cytokines have not yet been well investigated in BP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Detection of polymorphisms in <jats:italic>IL<\/jats:italic>\u2010<jats:italic>17A<\/jats:italic> (rs2275913 and rs3819025), <jats:italic>IL<\/jats:italic>\u2010<jats:italic>17F<\/jats:italic> (rs2397084 and rs763780), <jats:italic>IL<\/jats:italic>\u2010<jats:italic>17RA<\/jats:italic> (rs2229151), and <jats:italic>IL<\/jats:italic>\u2010<jats:italic>23R<\/jats:italic> (rs2201841, rs7530511, rs11209026, and rs10889677) genes were performed following the collection of blood samples and DNA extraction from BP patients and controls. Gene expression of <jats:italic>IL<\/jats:italic>\u2010<jats:italic>23R<\/jats:italic> was determined by quantitative RT\u2010PCR analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of <jats:italic>IL<\/jats:italic>\u2010<jats:italic>23R<\/jats:italic> rs7530511 genotypes and alleles, as well as IL\u201023R rs2201841 alleles, is significantly different between the BP patients and controls. While the minor C\u2010allele of <jats:italic>IL<\/jats:italic>\u2010<jats:italic>23R<\/jats:italic> rs7530511 is highly present in the patients, the G\u2010allele distribution of <jats:italic>IL<\/jats:italic>\u2010<jats:italic>23R<\/jats:italic> rs2201841 is significantly more prevalent in the control individuals compared to the BP patients. Genotypes and alleles of other SNPs in <jats:italic>IL<\/jats:italic>\u2010<jats:italic>17A<\/jats:italic>, <jats:italic>IL<\/jats:italic>\u2010<jats:italic>17F<\/jats:italic>, and <jats:italic>IL<\/jats:italic>\u2010<jats:italic>17RA<\/jats:italic> were similarly distributed in patients and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No alteration was found in the gene expression between wild and polymorphic genotypes of <jats:italic>IL<\/jats:italic>\u2010<jats:italic>23R<\/jats:italic> (rs2201841 and rs7530511) variations, indicating they do not contribute to altering the levels of gene expression in blood. In summary, our data show that the alleles of two SNPs in <jats:italic>IL<\/jats:italic>\u2010<jats:italic>23R<\/jats:italic> rs2201841 and rs7530511 are associated with BP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.1519","type":"journal-article","created":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T12:45:32Z","timestamp":1608381932000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["TH17\/IL23 cytokine gene polymorphisms in bullous pemphigoid"],"prefix":"10.1002","volume":"8","author":[{"given":"Pardis\u2010Sadat","family":"Tabatabaei\u2010Panah","sequence":"first","affiliation":[{"name":"Biology Department East Tehran Branch Islamic Azad University Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamideh","family":"Moravvej","sequence":"additional","affiliation":[{"name":"Skin Research Centre Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahel","family":"Aghaei","sequence":"additional","affiliation":[{"name":"Biology Department East Tehran Branch Islamic Azad University Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Akbari","sequence":"additional","affiliation":[{"name":"Biology Department East Tehran Branch Islamic Azad University Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakineh","family":"Rajabi","sequence":"additional","affiliation":[{"name":"Biology Department East Tehran Branch Islamic Azad University Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atena","family":"Kia","sequence":"additional","affiliation":[{"name":"Biology Department East Tehran Branch Islamic Azad University Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaheh","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Biology Department East Tehran Branch Islamic Azad University Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Sadaf","sequence":"additional","affiliation":[{"name":"Biology Department East Tehran Branch Islamic Azad University Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Atoon","sequence":"additional","affiliation":[{"name":"Biology Department East Tehran Branch Islamic Azad University Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasim","family":"Behravesh","sequence":"additional","affiliation":[{"name":"Biology Department East Tehran Branch Islamic Azad University Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf J.","family":"Ludwig","sequence":"additional","affiliation":[{"name":"L\u00fcbeck Institute of Experimental Dermatology University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7668-702X","authenticated-orcid":false,"given":"Reza","family":"Akbarzadeh","sequence":"additional","affiliation":[{"name":"Skin Research Centre Shahid Beheshti University of Medical Sciences Tehran Iran"},{"name":"L\u00fcbeck Institute of Experimental Dermatology University of L\u00fcbeck L\u00fcbeck Germany"},{"name":"Institute of Anatomy University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207577200"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100625.2011.01378.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.03.010"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8206983"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04753"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2018.09.003"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060244"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2010.08.006"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i2.176"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01355"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017160"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00779"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13717"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2012.1854"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14433"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.04.006"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16553"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2006.09.008"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04808"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041257"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2015.07.014"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.263"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(08)60725\u20104"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01752"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.2302\/kjm.52.128"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14002"},{"issue":"4","key":"e_1_2_8_28_1","first-page":"339","article-title":"Cytokines in autoimmune bullous skin diseases. Epiphenomena or contribution to pathogenesis?","volume":"144","author":"Ludwig R. J.","year":"2009","journal-title":"Giornale Italiano Di Dermatologia E Venereologia"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00603"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.03.044"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1698"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.03.014"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030896"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1586\/edm.09.23"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.103"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2016.2888"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1109017"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20103083.2010.02411.x"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep18001"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20103083.2009.02265.x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523\u20101747.ep12505705"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(12)61140\u20104"},{"issue":"9","key":"e_1_2_8_43_1","first-page":"11653","article-title":"Association between interleukin\u201017 gene polymorphisms and risk of coronary artery disease","volume":"8","author":"Shuang L.","year":"2015","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.9.5948"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00636"},{"issue":"5","key":"e_1_2_8_46_1","first-page":"8431","article-title":"Comparison of IL\u201023 receptor gene polymorphisms in patients with primary sj\u00f6gren syndrome, ankylosing spondylitis. and ankylosing spondylitis with sj\u00f6gren\u2019s syndrome","volume":"9","author":"Temel S.","year":"2016","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/416838"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(17)30560\u20103"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34437"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/967987"}],"container-title":["Molecular Genetics &amp; Genomic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mgg3.1519","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mgg3.1519","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mgg3.1519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T08:47:17Z","timestamp":1708505237000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mgg3.1519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":49,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1002\/mgg3.1519"],"URL":"https:\/\/doi.org\/10.1002\/mgg3.1519","archive":["Portico"],"relation":{},"ISSN":["2324-9269","2324-9269"],"issn-type":[{"type":"print","value":"2324-9269"},{"type":"electronic","value":"2324-9269"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"2020-08-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1519"}}