{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T09:55:21Z","timestamp":1786960521716,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,22]],"date-time":"2020-11-22T00:00:00Z","timestamp":1606003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81502230"],"award-info":[{"award-number":["81502230"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81802589"],"award-info":[{"award-number":["81802589"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp;amp; Gen Med"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>N<jats:sup>6<\/jats:sup>\u2010methyladenosine (m<jats:sup>6<\/jats:sup>A) modification is one of the critical gene regulatory mechanisms implicated in cancer biology. However, the roles of m<jats:sup>6<\/jats:sup>A regulators in ovarian cancer are still poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We integrated multiple databases including Gene Expression Omnibus (GEO), ROC Plotter, Kaplan\u2010Meier Plotter, and Tumor Immune Estimation Resource (TIMER) to explore clinicopathological significance of m<jats:sup>6<\/jats:sup>A regulators in ovarian cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We showed that alterations in the expression of m<jats:sup>6<\/jats:sup>A regulators were related to the malignancy and poor prognosis of ovarian cancer. We found decreased YTHDC1 and increased RBM15 expressions were associated with ovarian cancer cell metastases and HNRNPC was a predictor of paclitaxel resistance. Moreover, dysregulated m<jats:sup>6<\/jats:sup>A regulators were enriched in the activation of cancer\u2010related pathways. Our results further demonstrated that the level of immune cell infiltration and the expression of various immune gene markers were closely associated with the expressions of specific m<jats:sup>6<\/jats:sup>A regulators (RBM15B, ZC3H13, YTHDF1, and IGF2BP1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study establishes a new prognostic profile of ovarian cancer patients based on m<jats:sup>6<\/jats:sup>A regulators, and highlights the potential roles of m<jats:sup>6<\/jats:sup>A regulators in ovarian cancer development.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.1547","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T06:43:22Z","timestamp":1606113802000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Clinicopathological and immunological characterization of RNA m<sup>6<\/sup>A methylation regulators in ovarian cancer"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3924-3563","authenticated-orcid":false,"given":"Qingying","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Shanghai Tenth People\u2019s Hospital School of Medicine Tongji University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shanghai General Hospital Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingxian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Putuo Hospital Shanghai University of Traditional Chinese Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Integrated Therapy Shanghai Cancer Center Fudan University Shanghai China"},{"name":"Department of Oncology Shanghai Medical College Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0489-776X","authenticated-orcid":false,"given":"Jiawen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shanghai General Hospital Shanghai Jiao Tong University Shanghai 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