{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T01:50:02Z","timestamp":1780624202312,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2016A030313809"],"award-info":[{"award-number":["2016A030313809"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2020A1515010568"],"award-info":[{"award-number":["2020A1515010568"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["71573059"],"award-info":[{"award-number":["71573059"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp;amp; Gen Med"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Long non\u2010coding RNA (lncRNA) plays an essential role in hepatitis B virus\u2010related hepatocellular carcinoma (HBV\u2010related HCC) occurrence and development. Single nucleotide polymorphism (SNP) may affect HBV\u2010related HCC susceptibility by altering the function of lncRNA. However, the relationship between lncRNA SNPs and HBV\u2010related HCC occurrence and development is still unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the present study, based on HBV\u2010related HCC genome\u2010wide association studies, eight potentially functional SNPs from two lncRNAs were predicted using a set of bioinformatics strategies. In 643 HBV\u2010related HCC patients, 549 CHB carriers, and 553 HBV natural clearance subjects from Southern Chinese, we evaluated associations between SNPs and HBV\u2010related HCC occurrence or development with odds ratio (OR) and 95% confidence interval (CI) under credible genetic models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In HBV\u2010related HCC patients, rs9908998 was found to significantly increase the risk of lymphatic metastasis under recessive model (Adjusted OR = 1.95, 95% CI = 1.20\u20133.17). <jats:italic>Lnc<\/jats:italic>\u2010<jats:italic>RP11<\/jats:italic>\u2010<jats:italic>150O12<\/jats:italic>.<jats:italic>3<\/jats:italic> rs2275959, rs1008547, and rs11776545 with cancer family history may show significant multiplicative and additive interactions on HBV\u2010related HCC susceptibility (all <jats:italic>p<\/jats:italic><jats:sub>Adjusted<\/jats:sub> &lt; .05). The associations of rs2275959, rs1008547, and rs11776545 with distant metastasis of HBV\u2010related HCC patients were observed in additive model (Adjusted OR = 1.45, 95% CI = 1.06\u20131.97 for rs2275959; Adjusted OR = 1.45, 95% CI = 1.06\u20131.98 for rs1008547; Adjusted OR = 1.40, 95% CI = 1.03\u20131.91 for rs11776545).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Taken together, <jats:italic>lnc<\/jats:italic>\u2010<jats:italic>ACACA<\/jats:italic>\u2010<jats:italic>1<\/jats:italic> rs9908998, <jats:italic>lnc<\/jats:italic>\u2010<jats:italic>RP11<\/jats:italic>\u2010<jats:italic>150O12<\/jats:italic>.<jats:italic>3<\/jats:italic> rs2275959, rs1008547, and rs11776545 might be predictors for HBV\u2010related HCC risk or prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.1585","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T07:07:58Z","timestamp":1610694478000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The association of lncRNA SNPs and SNPs\u2010environment interactions based on GWAS with HBV\u2010related HCC risk and progression"],"prefix":"10.1002","volume":"9","author":[{"given":"Qing","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health Guangdong Pharmaceutical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health Guangdong Pharmaceutical University Guangzhou 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