{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:01:40Z","timestamp":1753869700236,"version":"3.41.2"},"reference-count":6,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp;amp; Gen Med"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The Met136Val mutation in <jats:italic>SCN8A<\/jats:italic> was described in a case of trigeminal neuralgia but no frequency among affected individuals was provided.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Direct sequencing of 123 individuals diagnosed with classic trigeminal neuralgia was performed aimed to detect the Met136Val change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No cases of classical trigeminal neuralgia studied had the Met136Val mutation in <jats:italic>SCN8A<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Met136Val mutation in <jats:italic>SCN8A<\/jats:italic> is not a frequent cause of classical trigeminal neuralgia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.1587","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T06:19:50Z","timestamp":1610691590000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Gain\u2010of\u2010function mutation Met136Val in <i>SCN8A<\/i> may not be a common cause of trigeminal neuralgia"],"prefix":"10.1002","volume":"9","author":[{"given":"Raymond F.","family":"Sekula","sequence":"first","affiliation":[{"name":"Department of Neurosurgery School of Medicine University of Pittsburgh Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Deeley","sequence":"additional","affiliation":[{"name":"Department of Oral Biology School of Dental Medicine University of Pittsburgh Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayley","family":"Denwood","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery School of Medicine University of Pittsburgh Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3392-6881","authenticated-orcid":false,"given":"Alexandre R.","family":"Vieira","sequence":"additional","affiliation":[{"name":"Department of Oral Biology School of Dental Medicine University of Pittsburgh Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,11]]},"reference":[{"key":"e_1_2_1_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pny191"},{"key":"e_1_2_1_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0072\u20109752(10)97056\u20105"},{"key":"e_1_2_1_6_4_1","doi-asserted-by":"publisher","DOI":"10.7754\/Clin.Lab.2016.160207"},{"key":"e_1_2_1_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419897623"},{"key":"e_1_2_1_6_6_1","unstructured":"Hammer M. F. Wagnon J. L. Mefford H. C. Meisler M. H. Adam M. P. Ardinger H. H. Pagon R. A. Wallace S. E. Bean L. J. H. Stephens K. &Amemiya A.(2016).SCN8A\u2010related epilepsy with encephalopathy. GeneReviews\u00ae [Internet]. :University of Washington. 1993\u20132020."},{"key":"e_1_2_1_6_7_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2016.00131"}],"container-title":["Molecular Genetics &amp; Genomic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mgg3.1587","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mgg3.1587","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mgg3.1587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T11:43:45Z","timestamp":1708515825000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mgg3.1587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,11]]},"references-count":6,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1002\/mgg3.1587"],"URL":"https:\/\/doi.org\/10.1002\/mgg3.1587","archive":["Portico"],"relation":{},"ISSN":["2324-9269","2324-9269"],"issn-type":[{"type":"print","value":"2324-9269"},{"type":"electronic","value":"2324-9269"}],"subject":[],"published":{"date-parts":[[2021,1,11]]},"assertion":[{"value":"2020-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1587"}}