{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T21:04:01Z","timestamp":1766869441326,"version":"3.41.2"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T00:00:00Z","timestamp":1610755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp;amp; Gen Med"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>IKZF1<\/jats:italic> is a relevant gene associated with the pathogenesis of acute lymphoblastic leukemia, and the <jats:italic>rs<\/jats:italic>4132601 (T&gt;G) and <jats:italic>rs<\/jats:italic>11978267 (A&gt;G) polymorphisms have been associated with the development of this disease in several populations. The aim of this study was to determine the allelic and genotypic frequencies of the <jats:italic>rs<\/jats:italic>4132601 and <jats:italic>rs<\/jats:italic>11978267 polymorphisms in two indigenous Mexican groups (Cora and Huichol) and Mestizo populations from Nayarit, Mexico, and compare them with the frequencies of both polymorphisms in other populations of the world.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred, 116, and 100 subjects from the Mestizo, Huichol, and Cora populations, respectively, all of them residents of the state of Nayarit, Mexico, were analyzed. The frequencies of rs4132601 and rs11978267 were determined by allelic discrimination using TaqMan assays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The allelic frequencies of rs4132601 were as follows: Mestizo group T\u00a0=\u00a00.74, G\u00a0=\u00a00.26; Cora T\u00a0=\u00a00.745, G\u00a0=\u00a00.255; and Huichol T\u00a0=\u00a00.47, G\u00a0=\u00a00.53. In the case of the rs11978267 polymorphism, the allelic frequencies were Mestizo A\u00a0=\u00a00.745, G\u00a0=\u00a00.255; Cora A\u00a0=\u00a00.735, G\u00a0=\u00a00.265; and Huichol A\u00a0=\u00a00.457, G\u00a0=\u00a00.543. For each population, both polymorphisms were in Hardy\u2013Weinberg equilibrium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The Huichol population from Nayarit presented the highest frequencies of the risk allele reported to date in the whole world for both <jats:italic>rs<\/jats:italic>4132601 and <jats:italic>rs<\/jats:italic>11978267 polymorphisms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.1589","type":"journal-article","created":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T12:39:40Z","timestamp":1610800780000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["High frequency of the risk allele of rs4132601 and rs11978267 from the <i>IKZF1<\/i> gene in indigenous Mexican population"],"prefix":"10.1002","volume":"9","author":[{"given":"Jorge","family":"Guti\u00e9rrez\u2010Franco","sequence":"first","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda Unidad Acad\u00e9mica 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Biolog\u00eda Molecular e Inmunolog\u00eda Unidad Acad\u00e9mica de Ciencias Qu\u00edmico Biol\u00f3gicas y Farmac\u00e9uticas Universidad Aut\u00f3noma de Nayarit Tepic Nayarit M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"S\u00e1nchez\u2010Meza","sequence":"additional","affiliation":[{"name":"Laboratorios de Investigaci\u00f3n en Biolog\u00eda Molecular e Inmunolog\u00eda Unidad Acad\u00e9mica de Ciencias Qu\u00edmico Biol\u00f3gicas y Farmac\u00e9uticas Universidad Aut\u00f3noma de Nayarit Tepic Nayarit M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helia Judith","family":"Pimentel\u2010Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Charit\u00e9 Universit\u00e4tsmedizin, Virchow\u2010Klinikum Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Francisco","family":"Zambrano\u2010Zaragoza","sequence":"additional","affiliation":[{"name":"Laboratorio de 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