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The symptoms related to coronavirus disease\u201019 (COVID\u201019) were different ranging from mild to severe lung injury and multi\u2010organ failure symptoms, eventually leading to death, especially in older patients with other co\u2010morbidities. The receptor of this virus in the human cell is angiotensin\u2010converting enzyme 2 (ACE2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this paper, we aimed to perform an <jats:italic>in silico<\/jats:italic> analysis of the frequently studied variants of the <jats:italic>ACE2<\/jats:italic> gene and determine the effects of the variants in mRNA secondary structure and binding affinity of cellular factors. Fourteen single\u2010nucleotide polymorphisms were selected based on previous studies and investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All of the variants were analyzed in the RNAsnp database and three revealed a significant <jats:italic>p<\/jats:italic>\u2010value. The spliceAid2 database prediction showed that 7 out of 14 SNPs caused an alteration in a way that only the wild or mutated form was able to bind to proteins. The latter database also reported that three SNPs produces a dual form in which different specific proteins can bind to the sequence in a specific form (either wild or mutated form).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Altogether, these estimations revealed the potential of variants in manipulation of the final stable form of ACE2 that can lead to different COVID\u201019 susceptibility.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.1672","type":"journal-article","created":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T08:51:01Z","timestamp":1617612661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Investigating the <i>ACE2<\/i> polymorphisms in COVID\u201019 susceptibility: An <i>in silico<\/i> analysis"],"prefix":"10.1002","volume":"9","author":[{"given":"Nasser","family":"Pouladi","sequence":"first","affiliation":[{"name":"Department of Biology Faculty of Basic 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