{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T18:47:33Z","timestamp":1773082053386,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T00:00:00Z","timestamp":1628208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin City","doi-asserted-by":"publisher","award":["16JCYBJC24200"],"award-info":[{"award-number":["16JCYBJC24200"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp;amp; Gen Med"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Understanding how genetic polymorphisms are associated with the pathophysiology of major depressive disorder (MDD) may aid in diagnosis and the development of personalized treatment strategies. <jats:italic>CNR1<\/jats:italic> is the gene coding Cannabinoid type 1 receptor which is highly involved in emotional processing and in regulating neurotransmitter releases. We aimed to investigate the associations of <jats:italic>CNR1<\/jats:italic> single\u2010nucleotide polymorphisms (SNPs) with MDD susceptibility and treatment response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study reported data on 181 Han Chinese with MDD and 80 healthy controls. The associations of <jats:italic>CNR1<\/jats:italic> genetic polymorphisms with MDD susceptibility and treatment response were examined, wherein the MDD patients were subgrouped further by responding to antidepressant treatment, compared with healthy controls separately.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:italic>CNR1<\/jats:italic> SNPs rs806367 and rs6454674 and haplotype C\u2010T\u2010T\u2010C of rs806366, rs806367, rs806368, and rs806370 were associated with increased susceptibility for MDD and antidepressant treatment resistance, but the association was not detected in other SNPs or the haplotype block of rs806368 and rs806370.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The <jats:italic>CNR1<\/jats:italic> is a promising candidate for the genetic association study of MDD. Larger and well\u2010characterized samples are required to confirm the genetic association of <jats:italic>CNR1<\/jats:italic> with MDD because of the limitations such as relatively small sample size and lack of information for correcting confounding factors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.1752","type":"journal-article","created":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T08:50:53Z","timestamp":1628239853000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The associations of <i>CNR1<\/i> SNPs and haplotypes with vulnerability and treatment response phenotypes in Han Chinese with major depressive disorder: A case\u2013control association study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3424-6004","authenticated-orcid":false,"given":"Chenghao","family":"Yang","sequence":"first","affiliation":[{"name":"Tianjin Mental Health Institute Tianjin Anding 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