{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T10:39:23Z","timestamp":1766486363889,"version":"3.41.2"},"reference-count":55,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T00:00:00Z","timestamp":1627257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp;amp; Gen Med"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Dozens of causative genes and their mechanisms of nonsyndromic cleft lip with or without cleft palate (NSCL\/P) were revealed through genome\u2010wide association and linkage studies. Results were, however, not always replicated in different populations or methodologies. This study used case\u2013control and family based approaches to investigate the etiology of NSCL\/P and its two subtypes: nonsyndromic cleft lip only (NSCLO) and nonsyndromic cleft lip and palate (NSCLP) among the Vietnamese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred and seventeen NSCL\/P case\u2010parent trios (one affected child and two parents), including 105 NSCLO and 112 NSCLP were involved for a family based design; and 273 ethnic and region\u2010matched healthy controls with no cleft history in their families were recruited for a case\u2013control design. Three SNPs consisting of<jats:italic>TFAP2A<\/jats:italic>(rs1675414 and rs303048) and 8q24 (rs987525) were genotyped using the TaqMan SNP genotyping assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>TFAP2A<\/jats:italic>rs1675414 was associated with NSCLO, replicated by both case\u2010control and family based tests. Other SNPs yielded no evidence of susceptibility to NSCL\/P or two subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The current investigation suggests an intriguing role of<jats:italic>TFAP2A<\/jats:italic>in the etiology of NSCLO among the Vietnamese population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.1754","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T16:40:54Z","timestamp":1627317654000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Family based and case\u2013control designs reveal an association of<i>TFAP2A<\/i>in nonsyndromic cleft lip only among Vietnamese population"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8103-0484","authenticated-orcid":false,"given":"Duc Minh","family":"Nguyen","sequence":"first","affiliation":[{"name":"Division of Research and Treatment for Oral Maxillofacial 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