{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T10:08:58Z","timestamp":1783073338428,"version":"3.54.6"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T00:00:00Z","timestamp":1629763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["5\/10\/FR\/10\/2015\u2010RCH"],"award-info":[{"award-number":["5\/10\/FR\/10\/2015\u2010RCH"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp; Gen Med"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Etiology of male infertility is intriguing and Y chromosome microdeletion within azoospermia factor (AZF) sub\u2010regions is considered major cause. We conducted a screening for Y chromosome microdeletion in an infertile male cohort from West Bengal, India to characterize Y chromosome microdeletion among infertile men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited case subjects that were categorized on the basis of sperm count as azoospermia (N\u00a0=\u00a063), severe oligozoospermia (N\u00a0=\u00a038), and oligozoospermia (N\u00a0=\u00a017) and compared them with age, demography, and ethnicity matched healthy proven fertile control males (N\u00a0=\u00a084). Sequence Tagged Site makers and polymerase chain reaction based profiling of Y chromosome was done for AZF region and SRY for cases and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We scored 16.1% of cases (19 out of 118) that bear one or more microdeletions in the studied loci and none among the controls. The aberrations were more frequent among azoospermic males (17 of 19) than in severe oligozoospermic subjects (2 of 19).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study provides the results of screening of the largest Bengali infertile men sample genotyped with the maximum number of STS markers spanning the entire length of Y chromosome long arm. Y chromosome microdeletion is a significant genetic etiology of infertility among Bengali men.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.1769","type":"journal-article","created":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T13:47:01Z","timestamp":1629812821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Prevalence of Y chromosome microdeletion in azoospermia factor subregions among infertile men from West Bengal, India"],"prefix":"10.1002","volume":"9","author":[{"given":"Saurav","family":"Dutta","sequence":"first","affiliation":[{"name":"Cytogenetics and Genomics Research Unit Department of Zoology University of Calcutta Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranab","family":"Paladhi","sequence":"additional","affiliation":[{"name":"Cytogenetics and Genomics Research Unit Department of Zoology University of Calcutta Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samudra","family":"Pal","sequence":"additional","affiliation":[{"name":"Cytogenetics and Genomics Research Unit Department of Zoology University of Calcutta Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunja","family":"Bose","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Medicine (IRM) Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Papiya","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Zoology Bijoy Krishna Girls\u2019 College (Affiliated to University of Calcutta) Howrah India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratna","family":"Chattopadhyay","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Medicine (IRM) Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baidyanath","family":"Chakravarty","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Medicine (IRM) Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1703-8446","authenticated-orcid":false,"given":"Sujay","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Cytogenetics and Genomics Research Unit Department of Zoology University of Calcutta Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3892\/br.2012.40"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02703336"},{"issue":"9","key":"e_1_2_9_4_1","first-page":"GC01\u20134","article-title":"Prevalence of Y chromosome microdeletions in idiopathic azoospermia cases in central Indian men","volume":"9","author":"Ambulkar P.","year":"2015","journal-title":"Journal of Clinical and Diagnostic Research"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.18006\/2017.5(1).007.013"},{"issue":"3","key":"e_1_2_9_6_1","first-page":"88","article-title":"Genetic risk of azoospermia factor (AZF) microdeletions in idiopathic cases of azoospermia and oligozoospermia in central Indian population","volume":"8","author":"Ambulkar P. 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