{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:17:49Z","timestamp":1771643869421,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T00:00:00Z","timestamp":1632268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp; Gen Med"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>NAD (P) H: quinone oxidoreductase (1) <jats:italic>(NQO1<\/jats:italic>\u2010<jats:bold>HGNC: 2874)<\/jats:bold> and myeloperoxidase (<jats:italic>MPO<\/jats:italic><jats:bold>\u2010HGNC: 7218<\/jats:bold>) are two enzymes involved in phase II of the xenobiotic metabolism pathway.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, a case\u2013control analysis was conducted to investigate the relationship between genetic variations in the <jats:italic>NQO1<\/jats:italic> <jats:bold>(C609T, rs1800566; IVS1\u201027 C &gt;G, rs689452)<\/jats:bold> and <jats:italic>MPO<\/jats:italic> <jats:bold>(G463A, rs2333227)<\/jats:bold> genes and the risk for bladder cancer among Tunisian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We have found that the <jats:italic>MPO 463GA<\/jats:italic> genotype was associated with a decreased risk of developing bladder cancer (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.049; OR\u00a0=\u00a00.696; 95% CI 0.484\u20130.999). In contrast, we have found that the <jats:italic>NQO1 609CT<\/jats:italic> genotype could increase the risk of bladder cancer patients (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.0039; OR\u00a0=\u00a01.454; 95% CI\u00a0=\u00a01.017\u20132.078). Moreover, patients with \u201cNQO1\u00a0609 CT\/IVS1\u201027 CG\u201d genotype show a 2.180\u2010fold increasing risk for developing bladder cancer in comparison to the control group with wild genotype. This OR is estimated at 5.6\u2010fold in smokers patients with \u201cNQO1\u00a0609 CT\/IVS1\u201027 CG\u201d genotype. Lastly, study findings suggest that the <jats:italic>NQO1 IVS<\/jats:italic>\u2010<jats:italic>27 *CG<\/jats:italic> genotype (rs689452) is associated with a risk of progression to muscle invasive bladder cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study suggests that environmental risk factors in association to <jats:italic>NQO1<\/jats:italic>\u00a0genotypes (NQO1\u00a0609 CT\/IVS1\u201027 CG) play an important role in the development of bladder cancer in Tunisian population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.1819","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T10:21:10Z","timestamp":1632306070000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Polymorphisms in <i>NQO1<\/i> and <i>MPO<\/i> genes and risk for bladder cancer in Tunisian population"],"prefix":"10.1002","volume":"9","author":[{"given":"Imen","family":"Hemissi","sequence":"first","affiliation":[{"name":"Laboratory of Protein Engineering and Bio\u2010active Molecules National Institute of Applied Science and Technology \u2010 University of Carthage Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haroun","family":"Ayed","sequence":"additional","affiliation":[{"name":"Urology Department Charles Nicolle Hospital Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeineb","family":"Naimi","sequence":"additional","affiliation":[{"name":"Medical oncology department Salah Azaiez Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khedija","family":"Meddeb","sequence":"additional","affiliation":[{"name":"Medical oncology department Salah Azaiez Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mouna","family":"Ayadi","sequence":"additional","affiliation":[{"name":"Medical oncology department Salah Azaiez Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Skander","family":"Zouari","sequence":"additional","affiliation":[{"name":"Urology Department Charles Nicolle Hospital Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selim","family":"Zaghbib","sequence":"additional","affiliation":[{"name":"Urology Department Charles Nicolle Hospital Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emna","family":"Talbi","sequence":"additional","affiliation":[{"name":"Biochemistry Department Charles Nicolle Hospital Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Chebil","sequence":"additional","affiliation":[{"name":"Urology Department Charles Nicolle Hospital Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3651-4690","authenticated-orcid":false,"given":"Slah","family":"Ouerhani","sequence":"additional","affiliation":[{"name":"Laboratory of Protein Engineering and Bio\u2010active Molecules National Institute of Applied Science and Technology \u2010 University of Carthage Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,22]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"8108","article-title":"FGFR3 and TP53 gene mutations define two distinct pathways in urothelial cell carcinoma of the bladder","volume":"63","author":"Bakkar A. 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