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Our objective was to study the association of gene expression levels of oxidative stress pathway genes (<jats:italic>ALOX12<\/jats:italic>, <jats:italic>ALOX15<\/jats:italic>, <jats:italic>ARG2<\/jats:italic>, <jats:italic>GSTT1<\/jats:italic>, <jats:italic>LPO<\/jats:italic>, <jats:italic>MPO<\/jats:italic>, <jats:italic>NDUFB3<\/jats:italic>, <jats:italic>PLA2G7<\/jats:italic>, and <jats:italic>SOD3)<\/jats:italic> and lung function forced expiratory volume in one second (FEV<jats:sub>1<\/jats:sub>), forced vital capacity (FVC) in Coronary Artery Risk Development in Young Adults study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Lung function was measured using spirometry and the Nanostring platform was used to estimate gene expression levels. Linear regression models were used to study association of lung function measured at year 30, 10\u2010year decline in lung function and gene expression after adjustment for center, smoking, and BMI, measured at year 25.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 10\u2010year decline of FEV<jats:sub>1<\/jats:sub> was faster in highest <jats:italic>NDUFB3<\/jats:italic> quartile compared to the lowest (difference\u00a0=\u00a0\u22122.09%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001) after adjustment for multiple comparisons. The 10\u2010year decline in FEV<jats:sub>1<\/jats:sub> and FVC was nominally slower in highest versus lowest quartile of <jats:italic>PLA2G7<\/jats:italic> (difference\u00a0=\u00a01.14%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02, and difference\u00a0=\u00a01.06%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.005, respectively). The other genes in the study were not associated with FEV<jats:sub>1<\/jats:sub> or FVC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Higher gene expression levels in oxidative stress pathway genes are associated with faster 10\u2010year FEV<jats:sub>1<\/jats:sub> decline.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.1832","type":"journal-article","created":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T06:55:59Z","timestamp":1637391359000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Gene expression of oxidative stress markers and lung function: A CARDIA lung study"],"prefix":"10.1002","volume":"9","author":[{"given":"Ramya","family":"Ramasubramanian","sequence":"first","affiliation":[{"name":"Division of Epidemiology and Community Health University of Minnesota School of Public Health Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi","family":"Kalhan","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago Illinois USA"},{"name":"Division of Pulmonary and Critical Care Medicine Northwestern University Feinberg School of Medicine Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"David R.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Community Health University of Minnesota School of Public Health Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George R.","family":"Washko","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Brigham and Women\u2019s Hospital Boston Massachusetts USA"},{"name":"Applied Chest Imaging Laboratory Brigham and Women\u2019s Hospital Boston 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