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Although there is considerable phenotypic variation among these diagnoses, these conditions are characterized by the presence of overlapping physical, medical, developmental, and psychological features. Our interdisciplinary clinic\u2019s experience anecdotally supports previous published findings of atopic conditions, feeding difficulties, and gastroesophageal reflux to be more prevalent in SCAs (Bardsley et al., <jats:italic>Journal of Pediatrics<\/jats:italic>, 2013, 163, 1085; Samango\u2010Sprouse et al., <jats:italic>The Application of Clinical Genetics<\/jats:italic>, 2019, 12, 191; Tartaglia et al., <jats:italic>Acta Paediatrica<\/jats:italic>, 2008, 100, 851). Furthermore, we observed that many of these patients have also been diagnosed with eosinophilic esophagitis (EoE), an association not currently reported in the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective chart review of all 667 patients with SCA seen at a large tertiary care center to investigate the prevalence and presenting features of EoE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four percent of children with SCAs had a biopsy\u2010confirmed diagnosis of EoE, which represents an odds ratio of 32 (95% CI 6\u2013185) when compared to the prevalence rates reported in the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Routine screening for EoE symptoms may be warranted for individuals with SCA and atopic conditions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.1833","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T07:43:06Z","timestamp":1636098186000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Eosinophilic esophagitis in individuals with sex chromosome aneuploidies: Clinical presentations and management implications"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7115-2165","authenticated-orcid":false,"given":"Susan","family":"Howell","sequence":"first","affiliation":[{"name":"Department of Pediatrics Section of Developmental Pediatrics University of Colorado School of Medicine Aurora Colorado USA"},{"name":"eXtraordinarY Kids Clinic and Research Program Children\u2019s Hospital Colorado Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Buchanan","sequence":"additional","affiliation":[{"name":"Dell Children\u2019s Medical Group Department of Clinical and Metabolic Genetics Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanlee M.","family":"Davis","sequence":"additional","affiliation":[{"name":"eXtraordinarY Kids Clinic and Research Program Children\u2019s Hospital Colorado Aurora Colorado USA"},{"name":"Department of Pediatrics Section of Endocrinology University of Colorado School of Medicine Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Miyazawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Gastrointestinal Eosinophilic Disease Program Section of Pediatric Gastroenterology Hepatology &amp; Nutrition University of Colorado School of Medicine Children\u2019s Hospital Colorado Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn T.","family":"Furuta","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Gastrointestinal Eosinophilic Disease Program Section of Pediatric Gastroenterology Hepatology &amp; Nutrition University of Colorado School of Medicine Children\u2019s Hospital Colorado Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole R.","family":"Tartaglia","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Section of Developmental Pediatrics University of Colorado School of Medicine Aurora Colorado USA"},{"name":"eXtraordinarY Kids Clinic and Research Program Children\u2019s Hospital Colorado Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Gastrointestinal Eosinophilic Disease Program Section of Pediatric Gastroenterology Hepatology &amp; 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