{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:43:53Z","timestamp":1790700233334,"version":"4.1.0"},"reference-count":149,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T00:00:00Z","timestamp":1644537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp; Gen Med"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Angelman syndrome (AS) is a rare neurogenetic disorder present in approximately 1\/12,000 individuals and characterized by developmental delay, cognitive impairment, motor dysfunction, seizures, gastrointestinal concerns, and abnormal electroencephalographic background. AS is caused by absent expression of the paternally imprinted gene\n                      <jats:italic>UBE3A<\/jats:italic>\n                      in the central nervous system. Disparities in the management of AS are a major problem in preparing for precision therapies and occur even in patients with access to experts and recognized clinics. AS patients receive care based on collective provider experience due to limited evidence\u2010based literature. We present a consensus statement and comprehensive literature review that proposes a standard of care practices for the management of AS at a critical time when therapeutics to alter the natural history of the disease are on the horizon.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We compiled the key recognized clinical features of AS based on consensus from a team of specialists managing patients with AS. Working groups were established to address each focus area with committees comprised of providers who manage &gt;5 individuals. Committees developed management guidelines for their area of expertise. These were compiled into a final document to provide a framework for standardizing management. Evidence from the medical literature was also comprehensively reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Areas covered by working groups in the consensus document include genetics, developmental medicine, psychology, general health concerns, neurology (including movement disorders), sleep, psychiatry, orthopedics, ophthalmology, communication, early intervention and therapies, and caregiver health. Working groups created frameworks, including flowcharts and tables, to help with quick access for providers. Data from the literature were incorporated to ensure providers had review of experiential versus evidence\u2010based care guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Standards of care in the management of AS are keys to ensure optimal care at a critical time when new disease\u2010modifying therapies are emerging. This document is a framework for providers of all familiarity levels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mgg3.1843","type":"journal-article","created":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T02:43:26Z","timestamp":1644633806000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["A multidisciplinary approach and consensus statement to establish standards of care for Angelman syndrome"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6605-1028","authenticated-orcid":false,"given":"Jessica","family":"Duis","sequence":"first","affiliation":[{"name":"Section of Genetics &amp; Inherited Metabolic Disease Section of Pediatrics, Special Care Department of Pediatrics Children\u2019s Hospital Colorado University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Nespeca","sequence":"additional","affiliation":[{"name":"Department of Neurology Rady Children\u2019s Hospital  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Summers","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne","family":"Bird","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Clinical Genetics \/ Dysmorphology University of California, San Diego Rady Children\u2019s Hospital San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen G.C.B.","family":"Bindels\u2010de Heus","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Erasmus MC Sophia Children\u2019s Hospital  Rotterdam Netherlands"},{"name":"ENCORE Expertise Center for Neurodevelopmental Disorders Erasmus MC University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Valstar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Erasmus MC Sophia Children\u2019s Hospital  Rotterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Claire Y.","family":"de Wit","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Erasmus MC Sophia Children\u2019s Hospital  Rotterdam Netherlands"},{"name":"Department of Neurology and Pediatric Neurology Erasmus MC  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Navis","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Erasmus MC Sophia Children\u2019s Hospital  Rotterdam Netherlands"},{"name":"Department of ENT (Speech &amp; Language Pathology) Erasmus MC  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maartje","family":"ten Hooven\u2010Radstaake","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Erasmus MC Sophia Children\u2019s Hospital  Rotterdam Netherlands"},{"name":"ENCORE Expertise Center for Neurodevelopmental Disorders Erasmus MC University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca M.","family":"van Iperen\u2010Kolk","sequence":"additional","affiliation":[{"name":"ENCORE Expertise Center for Neurodevelopmental Disorders Erasmus MC University Medical Center  Rotterdam The Netherlands"},{"name":"Department of Physical Therapy Erasmus MC  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Ernst","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melina","family":"Dendrinos","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Katz","sequence":"additional","affiliation":[{"name":"Developmental Pediatrics Department of Pediatrics Children\u2019s Hospital Colorado University of Colorado Anschutz Medical Campus  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Diaz\u2010Medina","sequence":"additional","affiliation":[{"name":"Division of Neurology and Developmental Pediatrics Department of Pediatrics Baylor College of Medicine  Houston Texas USA"},{"name":"Neurology Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshat","family":"Katyayan","sequence":"additional","affiliation":[{"name":"Division of Neurology and Developmental Pediatrics Department of Pediatrics Baylor College of Medicine  Houston Texas USA"},{"name":"Neurology Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srishti","family":"Nangia","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Child Neurology Weill Cornell Medicine New York\u2010Presbyterian Hospital  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Thibert","sequence":"additional","affiliation":[{"name":"Angelman Syndrome Program Lurie Center for Autism Massachusetts General Hospital for Children  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Glaze","sequence":"additional","affiliation":[{"name":"Division of Neurology and Developmental Pediatrics Department of Pediatrics Baylor College of Medicine  Houston Texas USA"},{"name":"Neurology Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Keary","sequence":"additional","affiliation":[{"name":"Angelman Syndrome Program Lurie Center for Autism Massachusetts General Hospital for Children  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Pelc","sequence":"additional","affiliation":[{"name":"Department of Neurology H\u00f4pital Universitaire des Enfants Reine Fabiola Universit\u00e9 Libre de Bruxelles (ULB)  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Boston Children\u2019s Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Sadhwani","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Boston Children\u2019s Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Heussler","sequence":"additional","affiliation":[{"name":"UQ Child Health Research Centre Faculty of Medicine The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Wheeler","sequence":"additional","affiliation":[{"name":"Center for Newborn Screening RTI International  Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Woeber","sequence":"additional","affiliation":[{"name":"Audiology, Speech &amp; Learning Services Children\u2019s Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"DeRamus","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Carolina Institute for Developmental Disabilities University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Thomas","sequence":"additional","affiliation":[{"name":"New York League for Early Learning William O'connor School  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Kertcher","sequence":"additional","affiliation":[{"name":"UNC Hospital Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"DeValk","sequence":"additional","affiliation":[{"name":"Occupational Therapy Children\u2019s Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Kalemeris","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rehabilitation Monroe Carell Jr. Children's Hospital at Vanderbilt  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara","family":"Arps","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Children\u2019s Hospital Colorado University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Baym","sequence":"additional","affiliation":[{"name":"Physical Therapy Children\u2019s Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Harris","sequence":"additional","affiliation":[{"name":"Physical Therapy Children\u2019s Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Gorham","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences University of Michigan  Ann Arbo Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda L.","family":"Bohnsack","sequence":"additional","affiliation":[{"name":"Division of Ophthalmology Department of Ophthalmology Ann &amp; Robert H. Lurie Children\u2019s Hospital of Chicago Northwestern University Feinberg School of Medicine  Ann Arbo Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reid C.","family":"Chambers","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Nationwide Children\u2019s Hospital  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Harris","sequence":"additional","affiliation":[{"name":"Division of Neurology and Developmental Pediatrics Department of Pediatrics Baylor College of Medicine  Houston Texas USA"},{"name":"Neurology Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry G.","family":"Chambers","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery San Diego Department of Pediatric Orthopedics University of California Rady Children\u2019s Hospital  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Okoniewski","sequence":"additional","affiliation":[{"name":"Center for Newborn Screening RTI International  Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth R.","family":"Jalazo","sequence":"additional","affiliation":[{"name":"Angelman Syndrome Foundation  Aurora Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allyson","family":"Berent","sequence":"additional","affiliation":[{"name":"Foundation for Angelman Syndrome Therapeutics  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Bacino","sequence":"additional","affiliation":[{"name":"Department of Molecular and Human Genetics Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Williams","sequence":"additional","affiliation":[{"name":"Raymond C. Philips Unit Division of Genetics and Metabolism Department of Pediatrics University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Anderson","sequence":"additional","affiliation":[{"name":"Division of Neurology and Developmental Pediatrics Department of Pediatrics Baylor College of Medicine  Houston Texas USA"},{"name":"Neurology Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1352\/1944\u20107558\u2010123.3.241"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.115709"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2012.10.001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102788.2010.01337.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13039\u2010016\u20100233\u20100"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsn032"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30154"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0012162204000398"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2011.05.020"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.2006.00803.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.26099"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.61382"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011409"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34297"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0025146"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073808314153"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387\u20107604(03)00160\u20108"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01376517\u2010200606000\u201000003"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320560213"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2016.248"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2006.10.001"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.2006.00902.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.837"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxab284"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0387\u20107604(94)00104\u20106"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.2009.02109.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx289"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328837"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.2007.01178_5.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.3109\/13816819009012942"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1352\/0895\u20108017(2004)109<275:SPIIWS>2.0.CO;2"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm288"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/children4090082"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2019.103554"},{"issue":"9","key":"e_1_2_7_36_1","first-page":"566","article-title":"Anesthesia in a patient with Angelman syndrome","volume":"54","author":"Errando C. L.","year":"2007","journal-title":"Revista Espanola De Anestesiologia Y Reanimacion"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442\u2010200X.2010.03118.x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37058"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803\u2010014\u20102189\u20104"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399\u20100004.1998.5440407.x"},{"issue":"1","key":"e_1_2_7_41_1","first-page":"43","article-title":"Three cases with severe motor and intellectual disabilities presenting the severest condition caused by prolonged non\u2010convulsive status epilepticus","volume":"35","author":"Fujikawa Y.","year":"2003","journal-title":"No to Hattatsu"},{"issue":"5","key":"e_1_2_7_42_1","first-page":"425","article-title":"Angelman syndrome: Physical characteristics and behavioural phenotype in 37 patients with confirmed genetic diagnosis","volume":"35","author":"Galvan\u2010Manso M.","year":"2002","journal-title":"Revista de Neurologia"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109592.2008.02487.x"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/DBP.0b013e3181ee408e"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269215506070693"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38401"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000000525"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883\u2010014\u20100232\u2010x"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/jar.12462"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2016.12.018"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0012162206002143"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18063126"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.2165\/00148581\u2010200305100\u201000001"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023\u2010019\u20101216\u20100"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.8284"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063\u2010019\u20103996\u2010x"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13072\u2010017\u20100134\u20104"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.83.6.670"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102788.2009.01177.x"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/mono.12143"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2015.12.004"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2020.02.007"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0034\u20109356(10)70181\u2010x"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010020\u20100858\u20106"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.734"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2010.58.2.207"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320400416"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnp.0000167930.90824.0f"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528\u20101157.2002.11302.x"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12225"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.7.912"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096\u20108628(19961218)66:3<356:AID\u2010AJMG21>3.0.CO;2\u2010K"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101157.1997.tb01097.x"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36864"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2014.09.022"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.3109\/17518423.2011.637972"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpa.2000.105305"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2018.01.027"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101157.1992.tb01763.x"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.5604\/15093492.1205024"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEP.0b013e3181575190"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36058"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2005.08.005"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2003.11.004"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052\u2010016\u20100301\u20104"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2010.12.013"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/jir.12195"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12309"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.2147\/JMDH.S55345"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102788.2009.01197.x"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102214.2006.00644.x"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/60.24.2583"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/ipd.12219"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073811419365"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2003.09.015"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0012162201001293"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5853167"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2014.55.6.1736"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109592.2008.02702.x"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2007.08.004"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2008.11.011"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20100004.2004.00362.x"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33509"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2018.02.006"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38694"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2013.09.007"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.3109\/17518423.2013.783140"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256\u2010015\u20100622\u20108"},{"key":"e_1_2_7_109_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e31827102a0"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0034\u20109356(09)70326\u20103"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.20217"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023\u2010018\u20100891\u20106"},{"key":"e_1_2_7_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.61140"},{"key":"e_1_2_7_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201859"},{"key":"e_1_2_7_115_1","doi-asserted-by":"publisher","DOI":"10.3109\/17518423.2014.980524"},{"key":"e_1_2_7_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2016.04.030"},{"key":"e_1_2_7_117_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11689\u2010017\u20109195\u20108"},{"key":"e_1_2_7_118_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0012162201000871"},{"key":"e_1_2_7_119_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102788.2010.01346.x"},{"key":"e_1_2_7_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/0887\u20108994(96)00011\u20102"},{"key":"e_1_2_7_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2009.03.005"},{"key":"e_1_2_7_122_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101157.1992.tb01762.x"},{"key":"e_1_2_7_123_1","doi-asserted-by":"publisher","DOI":"10.3109\/17518423.2012.676101"},{"key":"e_1_2_7_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2012.06.015"},{"key":"e_1_2_7_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33775"},{"key":"e_1_2_7_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38457"},{"key":"e_1_2_7_127_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.2009.02108.x"},{"key":"e_1_2_7_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2012.09.015"},{"key":"e_1_2_7_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.2012.03537.x"},{"key":"e_1_2_7_130_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528\u20101157.2003.66502.x"},{"key":"e_1_2_7_131_1","doi-asserted-by":"publisher","DOI":"10.1177\/112067210301300610"},{"key":"e_1_2_7_132_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246\u2010005\u20100985\u20105"},{"key":"e_1_2_7_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2011.11.027"},{"key":"e_1_2_7_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009\u20108981(66)90095\u20107"},{"key":"e_1_2_7_135_1","doi-asserted-by":"publisher","DOI":"10.1352\/0895-8017(2005)110[243:SIIWAS]2.0.CO;2"},{"key":"e_1_2_7_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2003.11.009"},{"key":"e_1_2_7_137_1","doi-asserted-by":"publisher","DOI":"10.5812\/aapm.57826"},{"key":"e_1_2_7_138_1","doi-asserted-by":"publisher","DOI":"10.1097\/DBP.0000000000000232"},{"key":"e_1_2_7_139_1","doi-asserted-by":"publisher","DOI":"10.1111\/jir.12635"},{"key":"e_1_2_7_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2003.09.014"},{"key":"e_1_2_7_141_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31074"},{"key":"e_1_2_7_142_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3181def138"},{"key":"e_1_2_7_143_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1L320"},{"key":"e_1_2_7_144_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00101\u2010011\u20101873\u20104"},{"key":"e_1_2_7_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2018.02.027"},{"key":"e_1_2_7_146_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1997.4617"},{"issue":"10","key":"e_1_2_7_147_1","first-page":"783","article-title":"Clinical manifestation and EEG characteristics of Angelman syndrome","volume":"48","author":"Yang X. Y.","year":"2010","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"e_1_2_7_148_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000018077"},{"key":"e_1_2_7_149_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem.1999.12.1.57"},{"key":"e_1_2_7_150_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307389200700307"}],"container-title":["Molecular Genetics &amp; Genomic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mgg3.1843","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mgg3.1843","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mgg3.1843","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T00:11:29Z","timestamp":1693095089000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mgg3.1843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,11]]},"references-count":149,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1002\/mgg3.1843"],"URL":"https:\/\/doi.org\/10.1002\/mgg3.1843","archive":["Portico"],"relation":{},"ISSN":["2324-9269","2324-9269"],"issn-type":[{"value":"2324-9269","type":"print"},{"value":"2324-9269","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,11]]},"assertion":[{"value":"2021-07-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1843"}}