{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:22:27Z","timestamp":1777512147350,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T00:00:00Z","timestamp":1640908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp; Gen Med"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Genetic variations of neutrophil cytosolic factor 2 (NCF2), a subunit of NADPH oxidase, are usually associated with chronic granulomatous disease, and their relationship with autoimmune disorders through the defective NADPH oxidase function during phagocytosis is suggested. Our study aimed to explore whether there is an association between the non\u2010synonymous single nucleotide polymorphism in the <jats:italic>NCF2<\/jats:italic> gene (rs17849502, NC_000001.11:g.183563445G&gt;T) and the development of juvenile autoimmune rheumatic diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In order to test this hypothesis, we conducted a pilot case\u2013control study. In total, 709 children and adolescents, all Belarusians, were involved in the study including patients with juvenile\u2010onset systemic lupus erythematosus (JSLE), juvenile idiopathic arthritis (JIA), Kawasaki disease (KD), and subjects without autoimmune and inflammatory diseases as the clinical control, as well as health newborns as the population control. Real\u2010time polymerase chain reaction was used for genotyping.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The minor T allele of <jats:italic>NCF2<\/jats:italic> occurred most frequently in patients with JSLE (OR\u00a0=\u00a02.60, 95% CI\u00a0=\u00a01.18\u20135.73, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.023 as compared to the clinical control). In groups with JIA and KD, its frequency did not differ from the control. The TT genotype was only observed in 5.7% of patients with JSLE (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.007), but not in other groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Therefore, our study suggested that <jats:italic>NCF2<\/jats:italic> rs17849502 polymorphism is a potential genetic risk factor for JSLE, while it is probably not for such autoimmune rheumatic diseases as JIA or KD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.1859","type":"journal-article","created":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T14:22:12Z","timestamp":1640960532000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Neutrophil cytosolic factor 2 (<i>NCF2<\/i>) gene polymorphism is associated with juvenile\u2010onset systemic lupus erythematosus, but probably not with other autoimmune rheumatic diseases in children"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4672-1124","authenticated-orcid":false,"given":"Ivan Y.","family":"Bakutenko","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Basis of Genome Stability Institute of Genetics and Cytology National Academy of Sciences of Belarus Minsk Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irena D.","family":"Haurylchyk","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Basis of Genome Stability Institute of Genetics and Cytology National Academy of Sciences of Belarus Minsk Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia V.","family":"Nikitchenko","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Basis of Genome Stability Institute of Genetics and Cytology National Academy of Sciences of Belarus Minsk Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena\u00a0V.","family":"Sechko","sequence":"additional","affiliation":[{"name":"1st Department of Childhood Diseases Belarusian State Medical University Minsk Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inna A.","family":"Kozyro","sequence":"additional","affiliation":[{"name":"1st Department of Childhood Diseases Belarusian State Medical University Minsk Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexei M.","family":"Tchitchko","sequence":"additional","affiliation":[{"name":"1st Department of Childhood Diseases Belarusian State Medical University Minsk Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galina M.","family":"Batyan","sequence":"additional","affiliation":[{"name":"1st Department of Childhood Diseases Belarusian State Medical University Minsk Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander V.","family":"Sukalo","sequence":"additional","affiliation":[{"name":"1st Department of Childhood Diseases Belarusian State Medical University Minsk Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4820-9722","authenticated-orcid":false,"given":"Nadezhda I.","family":"Ryabokon","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Basis of Genome Stability Institute of Genetics and Cytology National Academy of Sciences of Belarus Minsk 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