{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:02:08Z","timestamp":1753869728775,"version":"3.41.2"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp; Gen Med"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The vast majority of chronic myeloid leukemia (CML) patients have a single translocation t(9;22)(q34;q11), BCR\/ABL1 fusion genes, which is regarded as the hallmark of CML. However, around 5 to 10% of CML patients exhibit the involvement of a third chromosome. In some very rare cases a fourth or even fifth chromosome can be involved with the t(9;22).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This case report is based on a 40\u2010year\u2010old Saudi Arabian male patient, diagnosed with CML in lymphoid blast crisis, and observed to have a four\u2010way 46 XY, t(9;22;5;2)(q34;q11.2;p13;q44) translocation. The BCR\/ABL1 fusion was identified by fluorescent in situ hybridization (FISH). Additionally, the BCR\/ABL1 p210\u00a0mRNA fusion transcripts were identified by a molecular test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The clinical and prognostic impact of additional partner chromosomes to t(9;22) remains unknown. The CML patient with this novel four\u2010way translocation t(9;22;5;2) progressed to blast crisis and was resistant to Tyrosine Kinase Inhibitor (TKI) therapy. Therefore, this case is more in alignment with the negative impact of additional partner chromosomes to the translocation at t(9;22).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Here we report for the first time a novel four\u2010way translocation at t(9;22;5;2)(q34;q11.2;p13;q44).<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.1865","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T10:43:22Z","timestamp":1652265802000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Saudi Arabian CML patient with a novel four\u2010way translocation at t(9;22;5;2)(q34;q11.2;p13;q44)"],"prefix":"10.1002","volume":"10","author":[{"given":"Walid","family":"Dridi","sequence":"first","affiliation":[{"name":"Cytogenetics Unit, Pathology and Laboratory Medicine Department King Fahad Specialist Hospital\u2010Dammam  Dammam Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solaf","family":"Kanfar","sequence":"additional","affiliation":[{"name":"Hemato\u2010Oncology Adult Department King Fahad Specialist Hospital\u2010Dammam  Dammam Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9874-8532","authenticated-orcid":false,"given":"Patrick M. 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