{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T18:30:33Z","timestamp":1772562633710,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:00:00Z","timestamp":1641945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp; Gen Med"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A higher risk for breast and ovarian cancer has been reported in <jats:italic>BRCA<\/jats:italic> carriers and prophylactic surgeries are proposed to reduce this risk. This retrospective cohort study has evaluated the indication of <jats:italic>BRCA1<\/jats:italic>\/<jats:italic>2<\/jats:italic>\u00a0genetic tests in Iranian women and the rate of women's acceptance of prophylactic surgeries recommended by the surgeon.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records of 147\u00a0high\u2010risk women according to NCCN clinical practice guidelines who referred for BRCA mutations testing were assessed. Individual information, indications for <jats:italic>BRCA1<\/jats:italic>\/<jats:italic>2<\/jats:italic>\u00a0genetic testing and their results, physician recommendations, and type of accepted surgery were registered. To evaluate the current status of women an active visit follow\u2010up every six months was conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of women was 43.40\u00a0\u00b1\u00a010.94 and the median follow\u2010up time was 1.92\u00a0years. Genetic test results showed 49(33.3%) women were positive for either <jats:italic>BRCA1<\/jats:italic>\/<jats:italic>2<\/jats:italic>\u00a0mutations. Although the occurrence of breast cancer younger than 40 was the most common indication for genetic tests (26.5%), positive breast cancer history in first\u2010degree relatives and two relatives younger than 50 was the most common indications with positive results. The rate of acceptance of prophylactic mastectomy and bilateral salpingo\u2010oophorectomy was (14.3% and 34.7%) in <jats:italic>BRCA<\/jats:italic> mutation carriers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>If the onset of breast cancer at a young age (less than 40) will be the only indication for a <jats:italic>BRCA<\/jats:italic> analysis, the rate of a positive result (12.8%) is very low. Further studies are warranted to evaluate the age limit for genetic testing in our country. Prophylactic mastectomy acceptance is very low in <jats:italic>BRCA1<\/jats:italic>\/<jats:italic>2<\/jats:italic> carriers in our centers.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.1867","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T05:45:24Z","timestamp":1642052724000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of the indication of <i>BRCA1\/2<\/i> genetic tests in Iranian women and acceptance rate of risk\u2010reducing surgeries in <i>BRCA<\/i> mutation carriers"],"prefix":"10.1002","volume":"10","author":[{"given":"Mahtab","family":"Vasigh","sequence":"first","affiliation":[{"name":"Breast Disease Research Center Cancer Institute,Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bita","family":"Eslami","sequence":"additional","affiliation":[{"name":"Breast Disease Research Center Cancer Institute,Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Elahi","sequence":"additional","affiliation":[{"name":"Department of Surgery Alborz University of Medical Sciences  Karaj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Kaviani","sequence":"additional","affiliation":[{"name":"Breast Disease Research Center Cancer Institute,Tehran University of Medical Sciences  Tehran Iran"},{"name":"Department of Surgery Tehran University of Medical Sciences  Tehran Iran"},{"name":"Department of Surgical Oncology University de Montreal  Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Shirkoohi","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Cancer Research Center Cancer Institute Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keivan","family":"Majidzadeh","sequence":"additional","affiliation":[{"name":"Breast Cancer Research Center Motamed Cancer Institute, ACECR  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Newsha","family":"Nazarian","sequence":"additional","affiliation":[{"name":"Tehran Medical Sciences Branch Islamic Azad University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4785-281X","authenticated-orcid":false,"given":"Ramesh","family":"Omranipour","sequence":"additional","affiliation":[{"name":"Breast Disease Research Center Cancer Institute,Tehran University of Medical Sciences  Tehran Iran"},{"name":"Department of Surgical Oncology Cancer Institute, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2009.03.001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1407"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5328-7"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.04.179"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2019.07.014"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11271"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-19-0056"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-19-0056"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2004.05.018"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31937"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.3.979"},{"key":"e_1_2_8_13_1","first-page":"24","article-title":"Breast cancer in Iran: Results of a multi\u2010center study","volume":"5","author":"Harirchi I.","year":"2004","journal-title":"The Asian Pacific Journal of Cancer Prevention"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.5.889"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2015.04.016"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-011-9477-3"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-019-05162-7"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-006-0002-z"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-1465"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-020-01259-w"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23340"},{"key":"e_1_2_8_22_1","unstructured":"Nelson H. 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