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The DNA methylation (DNAm) profile in NCBRS is significantly different. DNAm is linked to the biological aging of cells and the health risks associated with biological aging. In this study, we examined changes in biological ages in NCBRS to provide insights into the prognosis and health risks of NCBRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used a publicly available dataset to examine biological aging in NCBRS using DNAm\u2010based epigenetic ages, such as PhenoAge and GrimAge, as well as DNAm\u2010based estimator of telomere length (DNAmTL). We investigated 12 cases, clinically diagnosed as NCBRS, and 27 controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to controls, NCBRS cases exhibited significantly accelerated PhenoAge and GrimAge as well as significantly shortened DNAmTL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest an acceleration of biological aging in NCBRS and provide insights into the prognosis and health risks of NCBRS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.1876","type":"journal-article","created":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T10:43:33Z","timestamp":1643453013000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Accelerated epigenetic age and shortened telomere length based on DNA methylation in Nicolaides\u2013Baraitser syndrome"],"prefix":"10.1002","volume":"10","author":[{"given":"Yutaka","family":"Shinko","sequence":"first","affiliation":[{"name":"Department of Psychiatry Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5953-5526","authenticated-orcid":false,"given":"Satoshi","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuo","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadasu","family":"Horai","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Kobe University Graduate School of Medicine  Kobe 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