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The aim of this study was to investigate the association among <jats:italic>TNFSF13B<\/jats:italic> gene (OMIM: 603969) single nucleotide polymorphisms (SNPs), <jats:italic>TNFSF13B<\/jats:italic> mRNA, and soluble BAFF (sBAFF) expression in patients with rheumatoid arthritis (RA) and primary Sj\u00f6gren's syndrome (pSS). The diagnostic value of sBAFF also was evaluated by the area under the curve (AUC) of receiver operating characteristic or receptor (ROC) curves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Genotypes of the <jats:italic>TNFSF13B<\/jats:italic> rs9514827 (\u22122841\u2009T\u2009&gt;\u2009C), rs1041569 (\u22122701 A\u2009&gt;\u2009T) and rs9514828 (\u2212871 C\u2009&gt;\u2009T) SNPs were determined by PCR\u2010RFLP assay. <jats:italic>TNFSF13B<\/jats:italic> mRNA and sBAFF expression were performed by RT\u2010qPCR and ELISA, respectively. The study included 320 RA patients, 101 pSS patients, and 309 healthy subjects (HS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The rs9514828 T allele and the TAT haplotype were associated with an increased risk to develop RA. In both ADs, the <jats:italic>TNFSF13B<\/jats:italic> mRNA levels were increased in comparison with HS. The rs9514828 (\u2212871 C\u2009&gt;\u2009T) polymorphism was associated with increased gene expression in RA patients. Also, sBAFF levels were higher in both ADs, however pSS patients showed the highest sBAFF levels. sBAFF showed higher diagnostic performance for pSS with an AUC of 0.968, with a similar accuracy of anti\u2010SSA\/Ro antibody diagnosis (AUC\u00a0=\u00a00.974).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings demonstrate that the <jats:italic>TNFSF13B<\/jats:italic> rs9514828 (\u2212871 C\u2009&gt;\u2009T) polymorphism is a risk factor for RA in the western Mexican population. sBAFF levels may be a potential diagnosis biomarker in pSS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.1950","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T08:45:33Z","timestamp":1649753133000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Analysis of <i>TNFSF13B<\/i> polymorphisms and <scp>BAFF<\/scp> expression in rheumatoid arthritis and primary Sj\u00f6gren's syndrome patients"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7050-0420","authenticated-orcid":false,"given":"Enrique","family":"Santill\u00e1n\u2010L\u00f3pez","sequence":"first","affiliation":[{"name":"Doctorado en Ciencias Biom\u00e9dicas (DCB) Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara  Guadalajara Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Francisco","family":"Mu\u00f1oz\u2010Valle","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Ciencias Biom\u00e9dicas (IICB) Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara  Guadalajara Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Oregon\u2010Romero","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Ciencias Biom\u00e9dicas (IICB) Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara  Guadalajara Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noem\u00ed","family":"Espinoza\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Doctorado en Ciencias en Biolog\u00eda Molecular en Medicina (DCBMM) Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara  Guadalajara Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz Alejandra","family":"Trevi\u00f1o\u2010Talavera","sequence":"additional","affiliation":[{"name":"Doctorado en Ciencias Biom\u00e9dicas (DCB) Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara  Guadalajara Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Celeste","family":"Salazar\u2010Camarena","sequence":"additional","affiliation":[{"name":"Grupo de Inmunolog\u00eda Molecular Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara  Guadalajara Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Mar\u00edn\u2010Rosales","sequence":"additional","affiliation":[{"name":"Grupo de Inmunolog\u00eda Molecular Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara  Guadalajara Mexico"},{"name":"Hospital General de Occidente Secretar\u00eda de Salud Jalisco  Guadalajara Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Cruz","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Ciencias Biom\u00e9dicas (IICB) Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara  Guadalajara Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhonatan Antonio","family":"Alvarez\u2010G\u00f3mez","sequence":"additional","affiliation":[{"name":"Doctorado en Ciencias en Biolog\u00eda Molecular en Medicina (DCBMM) Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara  Guadalajara Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nefertari","family":"Sagrero\u2010Fabela","sequence":"additional","affiliation":[{"name":"Doctorado en Ciencias Biom\u00e9dicas (DCB) Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara  Guadalajara Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Cerpa\u2010Cruz","sequence":"additional","affiliation":[{"name":"Servicio de Reumatolog\u00eda O.P.D. 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