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National guidelines recommend <jats:italic>BRCA1<\/jats:italic> or <jats:italic>BRCA2<\/jats:italic> mutation carriers consider RRM, but that carriers of moderate penetrance mutations (e.g., <jats:italic>ATM<\/jats:italic> or <jats:italic>CHEK2<\/jats:italic>) should be managed based on family history. We aimed to investigate determinants of decision for RRM, and hypothesized that mutation status, age, family history, partner status, and breast cancer would impact RRM decision making.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective study assessing RRM decisions for 279 women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Women with <jats:italic>BRCA<\/jats:italic> and moderate penetrance gene mutations, a personal history of breast cancer, or a first degree relative with a history of breast cancer were more likely to undergo RRM. Breast cancer status and age showed an interaction effect such that women with breast cancer were less likely to undergo RRM with increasing age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although national guidelines do not recommend RRM for moderate penetrance carriers, the rates of RRM for this population approached those for <jats:italic>BRCA<\/jats:italic> mutation carriers. Further insights are needed to better support RRM decision\u2010making in this population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.2031","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T12:18:57Z","timestamp":1661429937000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Risk\u2010reducing mastectomy decisions among women with mutations in high\u2010 and moderate\u2010 penetrance breast cancer susceptibility genes"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0944-5079","authenticated-orcid":false,"given":"Jacob G.","family":"Comeaux","sequence":"first","affiliation":[{"name":"Norris Comprehensive Cancer Center University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8658-3507","authenticated-orcid":false,"given":"Julie 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