{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T07:45:12Z","timestamp":1768722312876,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T00:00:00Z","timestamp":1661126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007224","name":"National Foundation for Science and Technology Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007224","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007224","name":"National Foundation for Science and Technology Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007224","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp; Gen Med"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The <jats:italic>JAK2<\/jats:italic> gene encodes for a non\u2010receptor tyrosine kinase that plays a key role in the JAK\/STAT signaling transfer pathway. Genetic polymorphisms of this gene have been indicated to be associated with myeloproliferative neoplasm\u2010associated thrombosis in recent studies. This research aimed to evaluate the association between the variant <jats:italic>rs10974944<\/jats:italic> and different types of Myeloproliferative neoplasms disorders in the Vietnamese population. DNA samples were obtained from 172 essential thrombocythemia patients, 14 primary myelofibrosis patients, 76 polycythemia vera patients, and 192 healthy controls. The <jats:italic>JAK2 rs10974944<\/jats:italic> and V617F genotypes were identified by the polymerase chain reaction\u2010restriction fragment length polymorphism genotyping and Sanger sequencing methods. Results showed that there was a strong association between <jats:italic>rs10974944<\/jats:italic> and Myeloproliferative neoplasms phenotype (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001) and the most significant association was observed in the recessive model of the mutant allele (G). The G allele carriers had a 1.74, 2.86, and 3.03 higher risk of getting essential thrombocythemia, primary myelofibrosis, and polycythemia vera, respectively. Interestingly, this effect of <jats:italic>rs10974944<\/jats:italic> seemed to be independent of the <jats:italic>JAK2<\/jats:italic> V617F genotype. The distribution of <jats:italic>rs10974944<\/jats:italic> genotypes were significantly different between V617F\u2010positive and negative groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.008). Moreover, the GG genotype of <jats:italic>rs10974944<\/jats:italic> was observed to be associated with the risk of getting Myeloproliferative neoplasms both in <jats:italic>JAK2<\/jats:italic> V617F\u2010positive group, and for the first time in <jats:italic>JAK2<\/jats:italic> V617F\u2010negative patients. A systematic meta\u2010analysis in different populations strengthened the evidence regarding the correlation between <jats:italic>rs10974944<\/jats:italic> and myeloproliferative neoplasm disorders. To sum up, our results suggested that <jats:italic>rs10974944<\/jats:italic> can be used as a predisposition screening marker for predicting Myeloproliferative neoplasms susceptibility.<\/jats:p>","DOI":"10.1002\/mgg3.2044","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T06:14:02Z","timestamp":1661235242000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["JAK2 rs10974944 is associated with both V617F\u2010positive and negative myeloproliferative neoplasms in a Vietnamese population: A potential genetic marker"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3181-9209","authenticated-orcid":false,"given":"Nguyen Thy","family":"Ngoc","sequence":"first","affiliation":[{"name":"Department of Life Sciences University of Science and Technology of Hanoi, Vietnam Academy of Science and Technology  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bui Bich","family":"Hau","sequence":"additional","affiliation":[{"name":"Department of Life Sciences University of Science and Technology of Hanoi, Vietnam Academy of Science and Technology  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Ba","family":"Vuong","sequence":"additional","affiliation":[{"name":"103 Hospital Vietnam Military Medical University  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3494-5136","authenticated-orcid":false,"given":"Nguyen Thi","family":"Xuan","sequence":"additional","affiliation":[{"name":"Vietnam Academy of Science and Technology Institute of Genome Research  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19041152"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-643544"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-021-01116-z"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2010.542260"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.57.6652"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.334"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.342"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12863-014-0147-y"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12380"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-019-02742-7"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2013.813500"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.00157"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.341"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.110"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2013(01)OA02"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-014-2266-y"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/1566524020666201015144702"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12765"},{"issue":"3","key":"e_1_2_10_20_1","first-page":"227","article-title":"Explaining odds ratios","volume":"19","author":"Szumilas M.","year":"2010","journal-title":"Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-013-1295-y"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23703"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14041"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-010-0960-y"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-10-695940"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0000000000000013"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq340"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2013.06.021"}],"container-title":["Molecular Genetics &amp; 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