{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:27:23Z","timestamp":1767706043244,"version":"3.41.2"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp; Gen Med"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neurofibromatosis 1 (NF1) is a common cancer predisposition syndrome. Affected individuals require lifelong surveillance and often suffer progressive disfigurement due to cutaneous neurofibromas. The aim of this research was to characterize health concerns and quality of life (QOL) in a population cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An online survey was completed by 68 adults and 32 parents of children with NF1, and 60 controls. The survey included the Skindex\u201029 QOL scale, 5D\u2010itch scale, and additional health questions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Frequency of itch was high in children (50%) and adults (69%), with most expressing interest in treatment for itch. The presence of itch and increased visibility of NF1 were predictors of poorer QoL. Many adults (53%) and parents (44%) desired access to treatment to improve cosmetic appearance. Muscle weakness\/tiredness was also prevalent amongst (60\u201370%) adults and children with NF1. Two\u2010thirds of adults with NF1 reported limited awareness of NF1 services and poor knowledge of surveillance, particularly breast screening in young women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study highlights the impact of NF1\u2010related itch and visibility in adults and children with a need for cosmetic and itch treatment. The findings emphasize a need for strategies to promote awareness, and access to management and treatment of NF1 in adults.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.2077","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T08:50:12Z","timestamp":1669711812000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Characterization of health concerns in people with neurofibromatosis type 1"],"prefix":"10.1002","volume":"11","author":[{"given":"Jane","family":"Fleming","sequence":"first","affiliation":[{"name":"Department of Clinical Genetics Northern Sydney Local Health District  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Morgan","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medicine University of Sydney, Northern Clinical School  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Northern Sydney Local Health District  Sydney New South Wales Australia"},{"name":"Department of Clinical Genetics The Children's Hospital at Westmead  Westmead New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy E.","family":"Schlub","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health, Faculty of Medicine and Health University of Sydney  Camperdown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2495-4928","authenticated-orcid":false,"given":"Yemima","family":"Berman","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Northern Sydney Local Health District  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277\u20109536(95)00076\u20103"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/lupus\u20102018\u2010000275"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005789"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20102241"},{"key":"e_1_2_11_6_1","unstructured":"Cancer Institute NSW. 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