{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T05:23:44Z","timestamp":1773465824035,"version":"3.50.1"},"reference-count":59,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp; Gen Med"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Genetic alterations can result in DNA repair defects, increasing susceptibility to breast cancer. The aim of this study was to evaluate the involvement of two DNA repair genes, <jats:italic>ERCC1<\/jats:italic> (<jats:italic>rs3212986,<\/jats:italic> GenBank NC_000073.9) and <jats:italic>ERCC2<\/jats:italic> (<jats:italic>rs1799793, rs13181<\/jats:italic>, GenBank: NC_000019.10<jats:italic>)<\/jats:italic> in the occurrence of breast cancer in Burkina Faso.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This case\u2013control study enrolled 128 participants including 64 patients and 64 healthy controls. Genotyping of polymorphisms were performed by real\u2010time PCR and PCR\u2010RFLP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The heterozygous AC genotype of the <jats:italic>ERCC2rs13181<\/jats:italic> polymorphism was associated with the occurrence of breast cancer when the mutant allele is inherited under the dominant pattern (CC\/AC vs AA; OR\u00a0=\u00a02.74, 95% IC (1.09\u20136.87); <jats:italic>p<\/jats:italic>\u00a0=\u00a0.028), but this association became insignificant after the Bonferroni correction (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.156). No association was observed between <jats:italic>ERCC1<\/jats:italic>rs3212986 and <jats:italic>ERCC2rs1799793<\/jats:italic> polymorphisms and breast cancer risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study showed that the heterozygous genotype (CA) of the <jats:italic>ERCC2rs13181<\/jats:italic> polymorphism may be associated with a risk of breast cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.2134","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T10:54:27Z","timestamp":1672743267000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Involvement of <i>ERCC1<\/i> (<i>rs3212986<\/i>) and <i>ERCC2<\/i> (<i>rs1799793<\/i>, <i>rs13181<\/i>) polymorphisms of DNA repair genes in breast cancer occurrence in Burkina Faso"],"prefix":"10.1002","volume":"11","author":[{"given":"Marc Donald 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