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CMA detected chromosomal abnormalities and pCNVs in approximately 50% and 2.5% of cases, respectively. The genomic disorders and syndromic pCNVs accounted for 31% of the detected pCNVs, and their incidences in POC ranged from 1\/750 to 1\/12,000. The newborn incidences of these genomic disorders and syndromic pCNVs were estimated in a range of 1\/4000 to 1\/50,000 live births from population genetic studies and diagnostic yields of a large case series of 32,587 pediatric patients. The risk of spontaneous abortion (SAB) for DiGeorge syndrome (DGS), Wolf\u2013Hirschhorn syndrome (WHS), and William\u2013Beuren syndrome (WBS) was 42%, 33%, and 21%, respectively. The estimated overall risk of SAB for major genomic disorders and syndromic pCNVs was approximately 38%, which was significantly lower than the 94% overall risk of SAB for chromosomal abnormalities. Further classification on levels of risk of SAB to high (&gt;75%), intermediate (51%\u201375%), and low (26%\u201350%) for known chromosomal abnormalities, genomic disorders, and syndromic pCNVs could provide evidence\u2010based interpretation in prenatal diagnosis and genetic counseling.<\/jats:p>","DOI":"10.1002\/mgg3.2181","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T07:43:38Z","timestamp":1680594218000},"source":"Crossref","is-referenced-by-count":12,"title":["Estimation on risk of spontaneous abortions by genomic disorders from a meta\u2010analysis of microarray results on large case series of pregnancy losses"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0307-9351","authenticated-orcid":false,"given":"Gang","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Genetics Yale University School of Medicine  New Haven Connecticut 06520 USA"},{"name":"Department of Medical &amp; 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