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Genome\u2010wide association studies (GWASs) of NSOFCs have demonstrated multiple risk loci and candidate genes; however, published risk factors are able to explain only a small fraction of the observed NSOFCs heritability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Here, we performed GWASs of 1615 NSCPO cases and 2340 controls, and then conducted genome\u2010wide meta\u2010analyses of NSOFCs, totaling 6812 NSCL\/P cases, 2614 NSCPO cases, and 19,165 controls from the Chinese Han population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identify 47 risk loci with genome\u2010wide <jats:italic>p<\/jats:italic><jats:sub>meta<\/jats:sub>\u2010value\u2009&lt;5.0\u2009\u00d7\u200910<jats:sup>\u22128<\/jats:sup>, 5 risk loci (1p32.1, 3p14.1, 3p14.3, 3p21.31, and 13q22.1) of which are new. All of the 47 susceptibility loci conjointly account for 44.12% of the NSOFCs\u2019 heritability in the Chinese Han population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results improve the comprehending of genetic susceptibility to NSOFCs and provide new views into the genetic etiology of craniofacial anomalies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.2226","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T13:28:10Z","timestamp":1686922090000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Genome\u2010wide meta\u2010analyses identify five new risk loci for nonsyndromic orofacial clefts in the Chinese Han population"],"prefix":"10.1002","volume":"11","author":[{"given":"Yafen","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Dermatology the First Affiliated Hospital of Anhui Medical University  Hefei 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