{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T04:51:38Z","timestamp":1780116698262,"version":"3.54.0"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:00:00Z","timestamp":1696204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200074"],"award-info":[{"award-number":["82200074"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp; Gen Med"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Among present reports, the T\/G allelic variation at the rs2609255 locus of the family sequence similarity gene 13A (<jats:italic>FAM13A<\/jats:italic>) was considerable associated with susceptibility to interstitial lung diseases (ILDs). In this study, we summarized relevant studies and applied a meta\u2010analysis to explore whether the polymorphism of rs2609255 site of the <jats:italic>FAM13A<\/jats:italic> gene can be utilized to predict susceptibility to idiopathic pulmonary fibrosis (IPF) patients or rheumatoid arthritis\u2010associated interstitial lung disease (RA\u2010ILD) or silicosis patients in different populations for the first time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared the frequency of G allele on rs2609255 site of <jats:italic>FAM13A<\/jats:italic> between the control subjects and IPF or RA\u2010ILD or silicosis patients from different races by using meta\u2010analysis. Nine studies were involved in this meta\u2010analysis, including five IPF studies, two RA\u2010ILD studies, and two silicosis studies, and containing 14 subgroups. We conducted separate meta\u2010analyses for different races.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all individuals, a substantial link between the G allele of the <jats:italic>FAM13A<\/jats:italic> rs2609255 polymorphism and IPF (OR: 1.47, 95% CI: 1.33\u20131.63, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001) was indicated. After dividing by ethnicity, the G allele was illustrated to be considerable correlation with IPF in Asian (OR: 2.63, 95% CI: 1.81\u20133.81, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001) and with RA\u2010ILD individuals (OR: 3.27, 95% CI: 1.26\u20138.49, <jats:italic>p<\/jats:italic>\u2009=\u20090.01). Conversely, there was no correlation with the G allele and IPF in European individuals (OR: 1.27, 95% CI: 0.89\u20131.83, <jats:italic>p<\/jats:italic>\u2009=\u20090.13) or silicosis in Chinese individuals (OR: 1.20, 95% CI: 0.99\u20131.46, <jats:italic>p<\/jats:italic>\u2009=\u20090.07).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first meta\u2010analysis that provides evidence that the rs2609255 of <jats:italic>FAM13A<\/jats:italic> might increase susceptibility to RA\u2010ILD, and IPF especially in Asian but not in European individuals, and not be correlated with silicosis in Chinese individuals, which indicated the differences in susceptibility to disease by race were noteworthy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.2279","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T06:39:56Z","timestamp":1696315196000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association of family sequence similarity gene 13A gene polymorphism and interstitial lung disease susceptibility: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1583-0862","authenticated-orcid":false,"given":"Yinan","family":"Hu","sequence":"first","affiliation":[{"name":"National Center for Respiratory Medicine  Beijing P.R. China"},{"name":"National Clinical Research Center for Respiratory Diseases  Beijing P.R. China"},{"name":"Institute of Respiratory Medicine, Chinese Academy of Medical Sciences  Beijing P.R. China"},{"name":"Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine China\u2010Japan Friendship Hospital  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Li","sequence":"additional","affiliation":[{"name":"China\u2010Japan Friendship Hospital  Beijing P.R. China"},{"name":"Chinese Academy of Medical Sciences, Peking Union Medical College  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Ren","sequence":"additional","affiliation":[{"name":"National Center for Respiratory Medicine  Beijing P.R. China"},{"name":"National Clinical Research Center for Respiratory Diseases  Beijing P.R. China"},{"name":"Institute of Respiratory Medicine, Chinese Academy of Medical Sciences  Beijing P.R. China"},{"name":"Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine China\u2010Japan Friendship Hospital  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaping","family":"Dai","sequence":"additional","affiliation":[{"name":"National Center for Respiratory Medicine  Beijing P.R. China"},{"name":"National Clinical Research Center for Respiratory Diseases  Beijing P.R. China"},{"name":"Institute of Respiratory Medicine, Chinese Academy of Medical Sciences  Beijing P.R. China"},{"name":"Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine China\u2010Japan Friendship Hospital  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,2]]},"reference":[{"issue":"5","key":"e_1_2_11_2_1","first-page":"577","article-title":"Correlation between single nucleotide polymorphisms of FAM13A gene rs2609255 and coal workers' pneumoconiosis","volume":"45","author":"Baojun Y.","year":"2018","journal-title":"China Occupational Medicine"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2017.11.003"},{"issue":"5","key":"e_1_2_11_4_1","article-title":"Genetic polymorphisms and their effects on the severity of silicosis in workers exposed to silica in Brazil","volume":"48","author":"Castro M. C. S.","year":"2022","journal-title":"Jornal brasileiro de pneumologia: Publicacao Oficial da Sociedade Brasileira de Pneumologia e Tisilogia"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2016.1256526"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2609"},{"issue":"9","key":"e_1_2_11_7_1","article-title":"Common idiopathic pulmonary fibrosis (ipf) genetic variants are associated with chronic hypersensitivity pneumonitis (chp)","volume":"203","author":"Furusawa H.","year":"2021","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.725144"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2022-002828"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2016.12.007"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab441"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00274"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1705751"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60235-9"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103463"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2021.105906"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-0867"},{"issue":"3","key":"e_1_2_11_19_1","first-page":"E100","article-title":"Loss of family with sequence similarity 13, member a exacerbates pulmonary fibrosis potentially by promoting epithelial to mesenchymal transition","volume":"65","author":"Rahardini E. P.","year":"2020","journal-title":"The Kobe Journal of Medical Sciences"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/2165079920967923"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2020.107798"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.120283"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2018.03.098"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01052-2"}],"container-title":["Molecular Genetics &amp; Genomic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mgg3.2279","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T03:46:38Z","timestamp":1700279198000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mgg3.2279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,2]]},"references-count":24,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/mgg3.2279"],"URL":"https:\/\/doi.org\/10.1002\/mgg3.2279","archive":["Portico"],"relation":{},"ISSN":["2324-9269","2324-9269"],"issn-type":[{"value":"2324-9269","type":"print"},{"value":"2324-9269","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,2]]},"assertion":[{"value":"2023-03-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2279"}}