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Although they are referred to as benign, tumor growth can eventually put pressure on nearby structures, spread to surrounding tissues, and cause symptoms. The exact cause of PA<\/jats:styled-content> is unknown, and the pathogenesis is multifactorial.<\/jats:p><\/jats:sec>Methods<\/jats:title>Our study included PA<\/jats:styled-content> patients and healthy volunteers. Genomic DNA<\/jats:styled-content> was extracted using the DNA<\/jats:styled-content> salting\u2010out method. All participants were genotyped for the KDR<\/jats:italic><\/jats:styled-content> rs2071559, rs1870377, CFH<\/jats:italic><\/jats:styled-content> rs1061170, and rs1410996 polymorphisms. Serum levels of KDR<\/jats:styled-content> and CFH<\/jats:styled-content> were examined using the ELISA<\/jats:styled-content> method.<\/jats:p><\/jats:sec>Results<\/jats:title>The results of the present study showed that KDR<\/jats:italic><\/jats:styled-content> rs2071559 A allele was associated with the occurrence of PA<\/jats:styled-content>, hormonally active PA<\/jats:styled-content>, invasive PA<\/jats:styled-content>, and PA<\/jats:styled-content> without recurrence development. KDR<\/jats:italic><\/jats:styled-content> rs1870377 increased the probability of invasive PA<\/jats:styled-content> and PA<\/jats:styled-content> recurrence. CFH<\/jats:italic><\/jats:styled-content> rs1061170 C allele was associated with hormonally active PA<\/jats:styled-content> and the T allele was associated with non\u2010invasive PA<\/jats:styled-content> development.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>KDR<\/jats:italic><\/jats:styled-content> rs2071559, rs1870377, and CFH<\/jats:italic><\/jats:styled-content> rs1061170 could be potential biomarkers associated with PA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.2289","type":"journal-article","created":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T18:35:44Z","timestamp":1696790144000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of KDR<\/i> (rs2071559, rs1870377), CFH<\/i> (rs1061170, rs1410996) genes variants and serum levels with pituitary adenoma"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6654-8575","authenticated-orcid":false,"given":"Akvile","family":"Bruzaite","sequence":"first","affiliation":[{"name":"Ophthalmology Laboratory Neuroscience Institute, Lithuanian University of Health Sciences, Medical Academy Kaunas Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Gedvilaite","sequence":"additional","affiliation":[{"name":"Ophthalmology Laboratory Neuroscience Institute, Lithuanian University of Health Sciences, Medical Academy Kaunas Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loresa","family":"Kriauciuniene","sequence":"additional","affiliation":[{"name":"Ophthalmology Laboratory Neuroscience Institute, Lithuanian University of Health Sciences, Medical Academy Kaunas Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasa","family":"Liutkeviciene","sequence":"additional","affiliation":[{"name":"Ophthalmology Laboratory Neuroscience Institute, Lithuanian University of Health Sciences, Medical Academy Kaunas Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,6]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI90962"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2021.e06251"},{"issue":"2","key":"e_1_2_14_4_1","first-page":"4","article-title":"The use of SNPs in pharmacogenomics studies","volume":"12","author":"Alwi Z. 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