{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T16:12:16Z","timestamp":1781194336774,"version":"3.54.1"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:00:00Z","timestamp":1700092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molec Gen &amp;amp; Gen Med"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Major sickle cell syndromes are the most common hemoglobinopathy in the world. The sickle cell patients are subjected to several factors causing inflammation, and the genetic identification of each individual allows to focus the possibility of allelic variations influence of a specific gene and then the polymorphism. This study aims at determining the distribution of <jats:italic>HP<\/jats:italic> gene (OMIM#140100) and their involvement on hematological parameters and the iron profile in the sickle cell patients presenting an inflammation condition during major sickle cell syndromes in Cameroun.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case\u2013control analytical study has been conducted over a period of 6 months. Cases consisting of sickle cell patients in a situation of inflammation and control of non\u2010inflamed sickle cell patients. The patients presenting major sickle cell syndromes, interned and\/or followed at the Hematology Department of the Regional Hospital of Bafoussam and the Central Hospital of Yaound\u00e9 have been recruited. <jats:italic>HP<\/jats:italic> genotyping was carried out at the Laboratory for Public Health Research Biotechnologies (LAPHER\u2010Biotech) in Yaound\u00e9 using allele\u2010specific PCR. Also, inflammatory, hematological parameters and martial assessment were explored by standard methods. Statistical analysis of the data was performed using the statistical tool R version 4.1.1. The comparison of proportions of alleles was made with the chi\u2010square test, and the Wilcoxon test was used to compare the median between different groups using the statistical tool R version 4.1.1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analyzed the samples of 149 patients. The <jats:italic>HP<\/jats:italic> polymorphism describes a significant frequency of the \u201c1F\u201d allele (69.8%) followed by the \u201c2\u201d allele (46.31%). In addition, 80 patients (53.69%), 48 (32.21%), and 21 (14.09%) presented the genotype <jats:italic>HP<\/jats:italic> 1\u20101, <jats:italic>HP<\/jats:italic> 2\u20101, and <jats:italic>HP<\/jats:italic> 2\u20102, respectively. And eighty\u2010one percent (81%) patients with genotype <jats:italic>HP<\/jats:italic> 2\u20102 showed a significant higher relative frequency of thrombocytosis compared with the genotype <jats:italic>HP<\/jats:italic> 1\u20101 and <jats:italic>HP<\/jats:italic> 2\u20101, respectively (51.2% and 68.8%, <jats:italic>p<\/jats:italic>\u2009=\u20090.087). The proportion of inflammation in the <jats:italic>HP<\/jats:italic> 2\u20102 group was higher (57.1%) compared with the other groups (respectively 42.5% and 35.4% in the <jats:italic>HP<\/jats:italic> 1\u20101 and <jats:italic>HP<\/jats:italic> 2\u20101 groups). Furthermore, the median CRP was significantly higher in the <jats:italic>HP<\/jats:italic> 2\u20102 group compared with the other groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.039). Moreover, the entire population of the <jats:italic>HP<\/jats:italic> 2\u20102 group showed an elevation of ferritin and IL6 unlike the <jats:italic>HP<\/jats:italic> 1\u20101 and <jats:italic>HP<\/jats:italic> 2\u20101 groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrates a higher frequency of genotype <jats:italic>HP<\/jats:italic> 1\u20101 followed by the <jats:italic>HP<\/jats:italic> 2\u20102 genotype in patients with major sickle cell syndromes. However, a larger proportion of patients with genotype <jats:italic>HP<\/jats:italic> 2\u20102 are associated with hematological profile disorders, inflammation, and dysregulation of iron metabolism. Then, the haptoglobin polymorphism contributes to the severity of major sickle cell syndromes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.2302","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T10:28:50Z","timestamp":1700130530000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Haptoglobin gene polymorphism and iron profile in sickle cell disease patients with inflammation in Yaounde, Cameroon"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2867-0538","authenticated-orcid":false,"given":"Romaric De Manfouo","family":"Tuono","sequence":"first","affiliation":[{"name":"Department of Hematology, Virology, and Infectious Disease, Faculty of Medicine and Biomedical Sciences University of Yaounde 1  Yaound\u00e9 Cameroon"},{"name":"Faculty of Health Sciences University of Montagnes  Bangangte Cameroon"},{"name":"Laboratory of Biochemistry, Department of Biochemistry, Faculty of Medicine and Biomedical Sciences University of Yaounde 1  Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josu\u00e9 Louokdom","family":"Simo","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences University of Montagnes  Bangangte Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prosper Cabral Biapa","family":"Nya","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Sciences University of Dschang  Dschang Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Paul","family":"Chedjou","sequence":"additional","affiliation":[{"name":"Public Health and Biotechnology Research Laboratory (LAPHER\u2010Biotech)  Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian Bernard Kengne","family":"Fotsing","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Sciences University of Dschang  Dschang Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard Claude","family":"Chetcha","sequence":"additional","affiliation":[{"name":"Department of Hematology, Virology, and Infectious Disease, Faculty of Medicine and Biomedical Sciences University of Yaounde 1  Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calvino Fomboh","family":"Tah","sequence":"additional","affiliation":[{"name":"Public Health and Biotechnology Research Laboratory (LAPHER\u2010Biotech)  Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude Tagny","family":"Tayou","sequence":"additional","affiliation":[{"name":"Department of Hematology, Virology, and Infectious Disease, Faculty of Medicine and Biomedical Sciences University of Yaounde 1  Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried Fon","family":"Mbatcham","sequence":"additional","affiliation":[{"name":"Public Health and Biotechnology Research Laboratory (LAPHER\u2010Biotech)  Yaound\u00e9 Cameroon"},{"name":"Department of Biochemistry, Faculty of Science University of Yaounde I  Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1602-6494","authenticated-orcid":false,"given":"Constant Anatole","family":"Pieme","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences University of Montagnes  Bangangte 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